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    Dgkz diacylglycerol kinase zeta [ Mus musculus (house mouse) ]

    Gene ID: 104418, updated on 5-Sep-2021

    Summary

    Official Symbol
    Dgkzprovided by MGI
    Official Full Name
    diacylglycerol kinase zetaprovided by MGI
    Primary source
    MGI:MGI:1278339
    See related
    Ensembl:ENSMUSG00000040479
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mDGK[z]; E130307B02Rik; F730209L11Rik
    Expression
    Broad expression in thymus adult (RPKM 128.6), cerebellum adult (RPKM 47.0) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dgkz in Genome Data Viewer
    Location:
    2; 2 E1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91763167..91806788, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91932822..91976443, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (91772979..91803720, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene autophagy/beclin 1 regulator 1 Neighboring gene cholinergic receptor, muscarinic 4 Neighboring gene predicted gene, 39876 Neighboring gene microRNA 6999 Neighboring gene midkine Neighboring gene cAMP responsive element binding protein 3-like 1 Neighboring gene predicted gene, 31473

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+ kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables diacylglycerol kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in diacylglycerol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycerolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in lipid phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in lipid phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of postsynaptic density structure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in maintenance of postsynaptic density structure IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in maintenance of postsynaptic density structure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic G1 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    diacylglycerol kinase zeta
    Names
    DAG kinase zeta
    DGK-zeta
    diglyceride kinase zeta
    NP_001160069.1
    NP_612179.2
    XP_006498600.1
    XP_006498601.1
    XP_006498602.1
    XP_006498603.1
    XP_006498604.1
    XP_006498605.1
    XP_006498606.1
    XP_011237543.1
    XP_011237546.1
    XP_017170356.1
    XP_017170364.1
    XP_017170367.1
    XP_030102338.1
    XP_036013070.1
    XP_036013088.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166597.1NP_001160069.1  diacylglycerol kinase zeta isoform 1

      See identical proteins and their annotated locations for NP_001160069.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK087503, BE862117, BY545365, CD564532
      Consensus CDS
      CCDS50643.1
      UniProtKB/TrEMBL
      A2AHK0
      Related
      ENSMUSP00000106934.2, ENSMUST00000111303.2
      Conserved Domains (7) summary
      smart00045
      Location:641798
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:492613
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:488811
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00204
      Location:9891105
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:9891083
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:9791015
      ANK; ANK repeat [structural motif]
      cl00040
      Location:367426
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    2. NM_138306.2NP_612179.2  diacylglycerol kinase zeta isoform 2

      See identical proteins and their annotated locations for NP_612179.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK087503, AK204403, BB834774, BQ443200, BY733951
      Consensus CDS
      CCDS16441.1
      UniProtKB/Swiss-Prot
      Q80UP3
      Related
      ENSMUSP00000028667.4, ENSMUST00000028667.10
      Conserved Domains (7) summary
      smart00045
      Location:447604
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:298419
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:294617
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00204
      Location:795911
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:795889
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:785821
      ANK; ANK repeat [structural motif]
      cl00040
      Location:173232
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      91763167..91806788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498539.1XP_006498602.1  diacylglycerol kinase zeta isoform X4

      Conserved Domains (5) summary
      smart00045
      Location:464621
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:315436
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      sd00045
      Location:854887
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:826920
      Ank_2; Ankyrin repeats (3 copies)
      cl00040
      Location:190240
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    2. XM_006498541.3XP_006498604.1  diacylglycerol kinase zeta isoform X7

      UniProtKB/TrEMBL
      A2AHJ7
      Related
      ENSMUSP00000106937.3, ENSMUST00000099709.10
      Conserved Domains (5) summary
      smart00045
      Location:464621
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:315436
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      sd00045
      Location:802838
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:812906
      Ank_2; Ankyrin repeats (3 copies)
      cl00040
      Location:190240
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    3. XM_006498543.2XP_006498606.1  diacylglycerol kinase zeta isoform X10

      Related
      ENSMUSP00000159231.2, ENSMUST00000239257.2
      Conserved Domains (5) summary
      smart00045
      Location:452609
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:303424
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      sd00045
      Location:790826
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:800894
      Ank_2; Ankyrin repeats (3 copies)
      cl00040
      Location:178228
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    4. XM_036157177.1XP_036013070.1  diacylglycerol kinase zeta isoform X6

      Conserved Domains (6) summary
      smart00045
      Location:452609
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:303424
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      sd00045
      Location:841874
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:813907
      Ank_2; Ankyrin repeats (3 copies)
      cd20849
      Location:93166
      C1_DGKzeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins
      cd20895
      Location:176250
      C1_DGKzeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins
    5. XM_006498540.2XP_006498603.1  diacylglycerol kinase zeta isoform X5

      Conserved Domains (5) summary
      smart00045
      Location:452609
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:303424
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      sd00045
      Location:842875
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:814908
      Ank_2; Ankyrin repeats (3 copies)
      cl00040
      Location:178228
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    6. XM_030246478.2XP_030102338.1  diacylglycerol kinase zeta isoform X9

      Conserved Domains (5) summary
      smart00045
      Location:447604
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:298419
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      sd00045
      Location:836869
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:808902
      Ank_2; Ankyrin repeats (3 copies)
      cl00040
      Location:173223
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    7. XM_006498542.5XP_006498605.1  diacylglycerol kinase zeta isoform X8

      Conserved Domains (5) summary
      smart00045
      Location:447604
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:298419
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      sd00045
      Location:837870
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:809903
      Ank_2; Ankyrin repeats (3 copies)
      cl00040
      Location:173223
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    8. XM_036157195.1XP_036013088.1  diacylglycerol kinase zeta isoform X13

      Conserved Domains (5) summary
      smart00045
      Location:225382
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:76197
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      sd00045
      Location:615648
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:587681
      Ank_2; Ankyrin repeats (3 copies)
      cl00040
      Location:123
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    9. XM_006498537.2XP_006498600.1  diacylglycerol kinase zeta isoform X1

      Conserved Domains (5) summary
      smart00045
      Location:641798
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:492613
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      sd00045
      Location:10311064
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:10031097
      Ank_2; Ankyrin repeats (3 copies)
      cl00040
      Location:367417
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    10. XM_006498538.3XP_006498601.1  diacylglycerol kinase zeta isoform X2

      Conserved Domains (5) summary
      smart00045
      Location:641798
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:492613
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      sd00045
      Location:10301063
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:10021096
      Ank_2; Ankyrin repeats (3 copies)
      cl00040
      Location:367417
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    11. XM_017314867.2XP_017170356.1  diacylglycerol kinase zeta isoform X3

      Conserved Domains (5) summary
      smart00045
      Location:641798
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:492613
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      sd00045
      Location:9801016
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:9901084
      Ank_2; Ankyrin repeats (3 copies)
      cl00040
      Location:367417
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    12. XM_017314878.1XP_017170367.1  diacylglycerol kinase zeta isoform X11

      Conserved Domains (5) summary
      smart00045
      Location:327484
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:178299
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      sd00045
      Location:717750
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:689783
      Ank_2; Ankyrin repeats (3 copies)
      cl00040
      Location:53103
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    13. XM_017314875.2XP_017170364.1  diacylglycerol kinase zeta isoform X11

      Conserved Domains (5) summary
      smart00045
      Location:327484
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:178299
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      sd00045
      Location:717750
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:689783
      Ank_2; Ankyrin repeats (3 copies)
      cl00040
      Location:53103
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    14. XM_011239241.4XP_011237543.1  diacylglycerol kinase zeta isoform X12

      Conserved Domains (3) summary
      smart00046
      Location:492613
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cl00040
      Location:367417
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl02440
      Location:641727
      DAGK_acc; Diacylglycerol kinase accessory domain
    15. XM_011239244.2XP_011237546.1  diacylglycerol kinase zeta isoform X14

      Conserved Domains (2) summary
      smart00046
      Location:492594
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cl00040
      Location:367417
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    RNA

    1. XR_003949943.2 RNA Sequence

    2. XR_374381.3 RNA Sequence

    3. XR_004937408.1 RNA Sequence

    4. XR_003949868.2 RNA Sequence

    5. XR_004937410.1 RNA Sequence

    6. XR_004937411.1 RNA Sequence

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