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    Rasgef1a RasGEF domain family, member 1A [ Mus musculus (house mouse) ]

    Gene ID: 70727, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rasgef1aprovided by MGI
    Official Full Name
    RasGEF domain family, member 1Aprovided by MGI
    Primary source
    MGI:MGI:1917977
    See related
    Ensembl:ENSMUSG00000030134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI835194; 6330404M18Rik
    Expression
    Biased expression in frontal lobe adult (RPKM 25.3), cortex adult (RPKM 24.6) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rasgef1a in Genome Data Viewer
    Location:
    6; 6 F1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (117988466..118068507)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (118011505..118091546)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (118016403..118041564)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene FXYD domain-containing ion transport regulator 4 Neighboring gene predicted gene, 38884 Neighboring gene Lasp1 pseudogene Neighboring gene microRNA 7044 Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 2 Neighboring gene predicted gene, 23908 Neighboring gene ret proto-oncogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    ras-GEF domain-containing family member 1A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316749.2NP_001303678.1  ras-GEF domain-containing family member 1A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 3. Variants 2 and 4 both encode the same isoform (2).
      Source sequence(s)
      AC135861
      Consensus CDS
      CCDS85141.1
      UniProtKB/TrEMBL
      A6H650, Q3TYC0
      Related
      ENSMUSP00000132244.3, ENSMUST00000164960.4
      Conserved Domains (2) summary
      cd06224
      Location:49176
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:218410
      RasGEF; RasGEF domain
    2. NM_001362103.1NP_001349032.1  ras-GEF domain-containing family member 1A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AC135861
      Consensus CDS
      CCDS90110.1
      Related
      ENSMUSP00000145214.2, ENSMUST00000203804.3
      Conserved Domains (2) summary
      cd06224
      Location:57163
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:235427
      RasGEF; RasGEF domain
    3. NM_001362104.1NP_001349033.1  ras-GEF domain-containing family member 1A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 3. Variants 2 and 4 both encode the same isoform (2).
      Source sequence(s)
      AC135861
      Consensus CDS
      CCDS85141.1
      Conserved Domains (2) summary
      cd06224
      Location:49176
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:218410
      RasGEF; RasGEF domain
    4. NM_001362105.1NP_001349034.1  ras-GEF domain-containing family member 1A isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (4) has a longer and distinct N-terminus and lacks an alternate internal segment compared to isoform 3.
      Source sequence(s)
      AC135861
      Conserved Domains (2) summary
      cd06224
      Location:60187
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      pfam00617
      Location:229421
      RasGEF; RasGEF domain
    5. NM_027526.1NP_081802.1  ras-GEF domain-containing family member 1A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.
      Source sequence(s)
      AK018120, AK158756, BY120855, BY256830
      Consensus CDS
      CCDS51883.1
      UniProtKB/TrEMBL
      A0A0N4SVF2, Q3TYC0
      Related
      ENSMUSP00000145077.2, ENSMUST00000203482.2
      Conserved Domains (2) summary
      cd06224
      Location:57184
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:222470
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      117988466..118068507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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