Ntf3 neurotrophin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ntf3provided by MGI
Official Full Name: neurotrophin 3provided by MGI
Primary source: MGI:MGI:97380
See related: Ensembl:ENSMUSG00000049107 AllianceGenome:MGI:97380
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nt3; HDNF; NGF-2; Ntf-3
Summary: This gene encodes a member of the neurotrophins that have a wide variety of functions in both neural and non-neural tissues. The encoded preproprotein undergoes proteolytic processing to generate a noncovalently linked homodimeric mature protein that can bind to the transmembrane receptor tyrosine kinases to initiate a series of signaling events. Mice lacking the encoded protein exhibit severe defects in the peripheral nervous system including a complete lack of spinal proprioceptive afferents and their peripheral sense organs. [provided by RefSeq, Sep 2016]
Expression: Broad expression in bladder adult (RPKM 4.6), limb E14.5 (RPKM 4.0) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 60.45 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (126078375..126143703, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (126101412..126166772, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation.
Title: Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation.
Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue.
Title: Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue.
miRNAs regulating the expressions of NTF3, GNG2 and ITGA7 are involved in the pathogenesis of abdominal aortic aneurysm in mice.
Title: miRNAs regulating the expressions of NTF3, GNG2 and ITGA7 are involved in the pathogenesis of abdominal aortic aneurysm in mice.
Protection from noise-induced cochlear synaptopathy by virally mediated overexpression of NT3.
Title: Protection from noise-induced cochlear synaptopathy by virally mediated overexpression of NT3.
Study of response to NT-3-mediated recovery after a T9 contusive spinal cord injury (SCI) in mice revealed that residual projections to lumbar motor neurons (MNs) are required to produce leg movements after SCI. NT-3 induced propriospino-MN circuit reorganization after the T9 contusion via promotion of dendritic regrowth rather than prevention of dendritic atrophy.
Title: Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice.
The data suggest that CADPS2-mediated secretion of BDNF/NT-3 may be involved in development and maturation of synapses and in the balance between inhibitory and excitatory synapses.
Title: Aspects of excitatory/inhibitory synapses in multiple brain regions are correlated with levels of brain-derived neurotrophic factor/neurotrophin-3.
NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation.
Title: NTF3 Is a Novel Target Gene of the Transcription Factor POU3F2 and Is Required for Neuronal Differentiation.
NT-3 modulates both synaptic transmission and plasticity in the striatum; nonetheless, synaptic plasticity was modified by 3-nitropropionic acid treatment, where instead of producing striatal long-term depression (LTD), long-term potentiation (LTP) was obtained. Moreover, the administration of NT-3 in the recording bath restored the plasticity observed under control conditions (LTD) in this model of striatal degeneration.
Title: Neurotrophin-3 restores synaptic plasticity in the striatum of a mouse model of Huntington's disease.
studies for the first time have shown that NT-3 increases muscle fiber diameter in the neurogenic muscle through direct activation of mTOR pathway and that the fiber size increase is more prominent for fast twitch glycolytic fibers
Title: AAV1.NT-3 gene therapy increases muscle fiber diameter through activation of mTOR pathway and metabolic remodeling in a CMT mouse model.
that the NT3-TrkA complex uses Ras/MAPK and/or PI3K-AKT signaling to induce axon growth and inhibit axon branching along intermediate targets
Title: Delineating neurotrophin-3 dependent signaling pathways underlying sympathetic axon growth along intermediate targets.

Submit: New GeneRIF Correction See all GeneRIFs (88)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (10) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

AI835689 (e-PCR)
- UniSTS:179466

UniSTS:225313 (e-PCR)
- UniSTS:225313

D6Mit333 (e-PCR), detects polymorphism
- UniSTS:130887

RH136134 (e-PCR)
- UniSTS:210129

Ntf3 (e-PCR), detects polymorphism
- UniSTS:507105

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables nerve growth factor binding	ISO Inferred from Sequence Orthology more info
enables nerve growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurotrophin p75 receptor binding	TAS Traceable Author Statement more info	PubMed
enables neurotrophin receptor binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon guidance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within enteric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epidermis development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within generation of neurons	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glial cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in induction of positive chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mechanoreceptor differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in nerve development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nerve growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within smooth muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neurotrophin-3

Names: nerve growth factor 2; neurotrophic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164034.2 → NP_001157506.1 neurotrophin-3 isoform a precursor

See identical proteins and their annotated locations for NP_001157506.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.

Source sequence(s)

AC124188, AC155837

Consensus CDS

CCDS51914.1

UniProtKB/TrEMBL

Q3V1A4

Related

ENSMUSP00000107863.3, ENSMUST00000112244.8

Conserved Domains (1) summary

pfam00243
Location:158 → 267

NGF; Nerve growth factor family
NM_001164035.2 → NP_001157507.1 neurotrophin-3 isoform a precursor

See identical proteins and their annotated locations for NP_001157507.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).

Source sequence(s)

AC124188, AC155837

Consensus CDS

CCDS51914.1

UniProtKB/TrEMBL

Q3V1A4

Related

ENSMUSP00000144828.2, ENSMUST00000204542.3

Conserved Domains (1) summary

pfam00243
Location:158 → 267

NGF; Nerve growth factor family
NM_001410128.1 → NP_001397057.1 neurotrophin-3 isoform b preproprotein

Status: VALIDATED

Source sequence(s)

AC124188, AC155837

UniProtKB/Swiss-Prot

P20181
NM_001410129.1 → NP_001397058.1 neurotrophin-3 isoform c precursor

Status: VALIDATED

Source sequence(s)

AC124188, AC155837
NM_008742.4 → NP_032768.1 neurotrophin-3 isoform b preproprotein

See identical proteins and their annotated locations for NP_032768.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks a portion of the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.

Source sequence(s)

AC124188, AC155837

Consensus CDS

CCDS20553.1

UniProtKB/Swiss-Prot

P20181

Related

ENSMUSP00000052302.8, ENSMUST00000050484.9

Conserved Domains (1) summary

pfam00243
Location:145 → 256

NGF; Nerve growth factor family