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    Ntf3 neurotrophin 3 [ Mus musculus (house mouse) ]

    Gene ID: 18205, updated on 8-Jul-2021

    Summary

    Official Symbol
    Ntf3provided by MGI
    Official Full Name
    neurotrophin 3provided by MGI
    Primary source
    MGI:MGI:97380
    See related
    Ensembl:ENSMUSG00000049107
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NT; NT-; Nt3; HDNF; Ntf-; NGF-2; Ntf-3; AI316846; AI835689
    Summary
    This gene encodes a member of the neurotrophins that have a wide variety of functions in both neural and non-neural tissues. The encoded preproprotein undergoes proteolytic processing to generate a noncovalently linked homodimeric mature protein that can bind to the transmembrane receptor tyrosine kinases to initiate a series of signaling events. Mice lacking the encoded protein exhibit severe defects in the peripheral nervous system including a complete lack of spinal proprioceptive afferents and their peripheral sense organs. [provided by RefSeq, Sep 2016]
    Expression
    Broad expression in bladder adult (RPKM 4.6), limb E14.5 (RPKM 4.0) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ntf3 in Genome Data Viewer
    Location:
    6 F3; 6 60.45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126078375..126143734, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126101412..126166772, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (126051430..126116762, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene anoctamin 2 Neighboring gene predicted gene, 33202 Neighboring gene predicted gene, 24947 Neighboring gene predicted gene 10415 Neighboring gene predicted gene, 33276 Neighboring gene 60S ribosomal protein L32 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nerve growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nerve growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables neurotrophin p75 receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables neurotrophin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within enteric nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within generation of neurons IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within glial cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in induction of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mechanoreceptor differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in memory IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myelination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nerve development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nerve growth factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuromuscular synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peripheral nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    neurotrophin-3
    Names
    nerve growth factor 2
    neurotrophic factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164034.1NP_001157506.1  neurotrophin-3 isoform a

      See identical proteins and their annotated locations for NP_001157506.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AA198264, AK132586, BC065785
      Consensus CDS
      CCDS51914.1
      UniProtKB/Swiss-Prot
      P20181
      UniProtKB/TrEMBL
      Q3V1A4
      Related
      ENSMUSP00000107863.3, ENSMUST00000112244.8
      Conserved Domains (1) summary
      pfam00243
      Location:158267
      NGF; Nerve growth factor family
    2. NM_001164035.1NP_001157507.1  neurotrophin-3 isoform a

      See identical proteins and their annotated locations for NP_001157507.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK132586, BC065785
      Consensus CDS
      CCDS51914.1
      UniProtKB/Swiss-Prot
      P20181
      UniProtKB/TrEMBL
      Q3V1A4
      Related
      ENSMUSP00000144828.2, ENSMUST00000204542.3
      Conserved Domains (1) summary
      pfam00243
      Location:158267
      NGF; Nerve growth factor family
    3. NM_008742.3NP_032768.1  neurotrophin-3 isoform b preproprotein

      See identical proteins and their annotated locations for NP_032768.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a portion of the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AA198264, AK132586, BC065785, CJ049238
      Consensus CDS
      CCDS20553.1
      UniProtKB/Swiss-Prot
      P20181
      UniProtKB/TrEMBL
      Q3V1A4
      Related
      ENSMUSP00000052302.8, ENSMUST00000050484.9
      Conserved Domains (1) summary
      pfam00243
      Location:145254
      NGF; Nerve growth factor family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      126078375..126143734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505715.4XP_006505778.1  neurotrophin-3 isoform X1

      Conserved Domains (1) summary
      pfam00243
      Location:165274
      NGF; Nerve growth factor family
    2. XM_006505716.3XP_006505779.1  neurotrophin-3 isoform X2

      See identical proteins and their annotated locations for XP_006505779.1

      UniProtKB/Swiss-Prot
      P20181
      Conserved Domains (1) summary
      pfam00243
      Location:145254
      NGF; Nerve growth factor family
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