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    Vash1 vasohibin 1 [ Mus musculus (house mouse) ]

    Gene ID: 238328, updated on 7-Aug-2021

    Summary

    Official Symbol
    Vash1provided by MGI
    Official Full Name
    vasohibin 1provided by MGI
    Primary source
    MGI:MGI:2442543
    See related
    Ensembl:ENSMUSG00000021256
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TTCP 1; AI834978; D930046M13Rik; G630009D10Rik
    Expression
    Broad expression in whole brain E14.5 (RPKM 15.3), CNS E14 (RPKM 13.4) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Vash1 in Genome Data Viewer
    Location:
    12; 12 D2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (86725474..86742462)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (86678700..86695688)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (88019650..88036631)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene poly(rC) binding protein 2 pseudogene Neighboring gene predicted gene, 22004 Neighboring gene angel homolog 1 Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene predicted gene, 32755

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallocarboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metallocarboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within labyrinthine layer blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of lymphangiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within placenta blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within response to wounding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tubulinyl-Tyr carboxypeptidase 1
    Names
    tyrosine carboxypeptidase 1
    NP_796328.2
    XP_011242409.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177354.4NP_796328.2  tubulinyl-Tyr carboxypeptidase 1

      See identical proteins and their annotated locations for NP_796328.2

      Status: VALIDATED

      Source sequence(s)
      AC102689
      Consensus CDS
      CCDS49118.1
      UniProtKB/Swiss-Prot
      Q8C1W1
      Related
      ENSMUSP00000021681.4, ENSMUST00000021681.4
      Conserved Domains (1) summary
      pfam14822
      Location:68312
      Vasohibin; Vasohibin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      86725474..86742462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244107.4XP_011242409.1  tubulinyl-Tyr carboxypeptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_011242409.1

      Conserved Domains (1) summary
      pfam14822
      Location:1149
      Vasohibin
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