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    Ttc28 tetratricopeptide repeat domain 28 [ Mus musculus (house mouse) ]

    Gene ID: 209683, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ttc28provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 28provided by MGI
    Primary source
    MGI:MGI:2140873
    See related
    Ensembl:ENSMUSG00000033209
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TPR; TPRBK; AI428795; AI851761; BC002262; 6030435N04; 2310015L07Rik
    Expression
    Broad expression in whole brain E14.5 (RPKM 8.8), CNS E14 (RPKM 8.2) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Ttc28 in Genome Data Viewer
    Location:
    5; 5 F
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (111027652..111437646)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110879785..111289780)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (111308822..111718799)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ES cell cis-regulatory motif 10b Neighboring gene HscB iron-sulfur cluster co-chaperone Neighboring gene checkpoint kinase 2 Neighboring gene microRNA 701 Neighboring gene predicted gene, 35628 Neighboring gene phosphatidylinositol transfer protein, beta Neighboring gene predicted gene, 36027 Neighboring gene meningioma 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7623

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in mitotic spindle midzone ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    tetratricopeptide repeat protein 28
    Names
    TPR repeat protein 28
    NP_001254551.1
    XP_006534908.1
    XP_006534909.1
    XP_030110193.1
    XP_030110194.1
    XP_030110195.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267622.1NP_001254551.1  tetratricopeptide repeat protein 28

      See identical proteins and their annotated locations for NP_001254551.1

      Status: INFERRED

      Source sequence(s)
      AC121934, AC122226, AC124425, AC155173, AW492543, BC046779
      Consensus CDS
      CCDS59682.1
      UniProtKB/Swiss-Prot
      Q80XJ3
      Related
      ENSMUSP00000137609.2, ENSMUST00000156290.9
      Conserved Domains (7) summary
      smart00028
      Location:388420
      TPR; Tetratricopeptide repeats
      COG0457
      Location:688989
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:85115
      TPR; TPR repeat [structural motif]
      pfam12770
      Location:13841707
      CHAT; CHAT domain
      pfam13176
      Location:953988
      TPR_7; Tetratricopeptide repeat
      pfam13414
      Location:88151
      TPR_11; TPR repeat
      pfam13424
      Location:309380
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      111027652..111437646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534845.5XP_006534908.1  tetratricopeptide repeat protein 28 isoform X1

      Conserved Domains (5) summary
      PHA03377
      Location:19502334
      PHA03377; EBNA-3C; Provisional
      TIGR02917
      Location:27838
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:495523
      TPR; TPR repeat [structural motif]
      pfam12770
      Location:12911614
      CHAT; CHAT domain
      pfam17874
      Location:7331053
      TPR_MalT; MalT-like TPR region
    2. XM_030254333.2XP_030110193.1  tetratricopeptide repeat protein 28 isoform X3

      Conserved Domains (5) summary
      PHA03377
      Location:18842268
      PHA03377; EBNA-3C; Provisional
      COG0457
      Location:278552
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:429457
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:834904
      TPR_12; Tetratricopeptide repeat
      pfam12770
      Location:12251548
      CHAT; CHAT domain
    3. XM_030254334.2XP_030110194.1  tetratricopeptide repeat protein 28 isoform X3

      Conserved Domains (5) summary
      PHA03377
      Location:18842268
      PHA03377; EBNA-3C; Provisional
      COG0457
      Location:278552
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:429457
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:834904
      TPR_12; Tetratricopeptide repeat
      pfam12770
      Location:12251548
      CHAT; CHAT domain
    4. XM_030254335.2XP_030110195.1  tetratricopeptide repeat protein 28 isoform X3

      Conserved Domains (5) summary
      PHA03377
      Location:18842268
      PHA03377; EBNA-3C; Provisional
      COG0457
      Location:278552
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:429457
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:834904
      TPR_12; Tetratricopeptide repeat
      pfam12770
      Location:12251548
      CHAT; CHAT domain
    5. XM_006534846.5XP_006534909.1  tetratricopeptide repeat protein 28 isoform X2

      Conserved Domains (5) summary
      PHA03377
      Location:19312315
      PHA03377; EBNA-3C; Provisional
      TIGR02917
      Location:9819
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:476504
      TPR; TPR repeat [structural motif]
      pfam12770
      Location:12721595
      CHAT; CHAT domain
      pfam17874
      Location:7141034
      TPR_MalT; MalT-like TPR region

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024477.3: Suppressed sequence

      Description
      NM_024477.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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