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    Camk2a calcium/calmodulin-dependent protein kinase II alpha [ Mus musculus (house mouse) ]

    Gene ID: 12322, updated on 8-Jul-2021

    Summary

    Official Symbol
    Camk2aprovided by MGI
    Official Full Name
    calcium/calmodulin-dependent protein kinase II alphaprovided by MGI
    Primary source
    MGI:MGI:88256
    See related
    Ensembl:ENSMUSG00000024617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CaMKII; R74975; mKIAA0968
    Expression
    Biased expression in cortex adult (RPKM 365.9) and frontal lobe adult (RPKM 310.4) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Camk2a in Genome Data Viewer
    Location:
    18 E1; 18 34.41 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61058379..61121224)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60925307..60988152)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (61085286..61147806)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm879 Neighboring gene arylsulfatase i Neighboring gene microRNA 7220 Neighboring gene microRNA 6982 Neighboring gene solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 Neighboring gene caudal type homeobox 1 Neighboring gene predicted gene, 52351

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activating protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in NMDA selective glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiotensin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calmodulin dependent kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ionotropic glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-threonine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postsynaptic neurotransmitter receptor diffusion trapping ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endocannabinoid signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of mitochondrial membrane permeability involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic vesicle docking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic vesicle docking IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to ischemia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    part_of calcium- and calmodulin-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase type II subunit alpha
    Names
    CaMK II
    alpha-CaMKII
    caM kinase II subunit alpha
    caMK-II subunit alpha
    NP_001273738.1
    NP_033922.1
    NP_803126.1
    XP_006525604.1
    XP_017173294.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286809.1NP_001273738.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a significant portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 2. The resulting isoform (3) is shorter and has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AK083245, AW490258, BB659027, BC031745, BY713276
      Consensus CDS
      CCDS70898.1
      UniProtKB/Swiss-Prot
      P11798
      UniProtKB/TrEMBL
      F8WHB5
      Related
      ENSMUSP00000048325.7, ENSMUST00000039904.7
      Conserved Domains (1) summary
      pfam08332
      Location:57184
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    2. NM_009792.3NP_033922.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1 precursor

      See identical proteins and their annotated locations for NP_033922.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, lacks a significant portion of the 5' coding region, initiates translation at an alternate start codon, and has an additional internal exon in the coding region, compared to variant 2. The resulting isoform (1) is shorter and has a distinct N-terminus and an additional internal segment, compared to isoform 2.
      Source sequence(s)
      AC124431
      Consensus CDS
      CCDS29277.1
      UniProtKB/Swiss-Prot
      P11798
      Related
      ENSMUSP00000110950.3, ENSMUST00000115295.9
      Conserved Domains (1) summary
      pfam08332
      Location:68195
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    3. NM_177407.4NP_803126.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2

      See identical proteins and their annotated locations for NP_803126.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AK083245, AW490258, BC031745
      Consensus CDS
      CCDS29276.1
      UniProtKB/Swiss-Prot
      P11798
      Related
      ENSMUSP00000099952.4, ENSMUST00000102888.10
      Conserved Domains (2) summary
      cd14086
      Location:11302
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:346473
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      61058379..61121224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525541.4XP_006525604.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_006525604.1

      UniProtKB/TrEMBL
      F8WIS9
      Related
      ENSMUSP00000025519.5, ENSMUST00000025519.11
      Conserved Domains (2) summary
      cd14086
      Location:11302
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:357484
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    2. XM_017317805.2XP_017173294.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2

      Conserved Domains (2) summary
      cd14086
      Location:11302
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:346473
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
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