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    Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 16485, updated on 6-May-2021

    Summary

    Official Symbol
    Kcna1provided by MGI
    Official Full Name
    potassium voltage-gated channel, shaker-related subfamily, member 1provided by MGI
    Primary source
    MGI:MGI:96654
    See related
    Ensembl:ENSMUSG00000047976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sh; Kv1.; MBK1; Mk-1; Shak; mcep; Kv1.1; mceph; Kca1-1; AI840627
    Expression
    Biased expression in cerebellum adult (RPKM 30.6), cortex adult (RPKM 12.5) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Kcna1 in Genome Data Viewer
    Location:
    6 F3; 6 61.57 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126613426..126622764, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126636463..126645801, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (126586481..126595819, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33449 Neighboring gene predicted gene, 33496 Neighboring gene potassium voltage-gated channel, shaker-related, subfamily, member 6 Neighboring gene predicted gene, 33581 Neighboring gene predicted gene, 20190

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC124402

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell communication by electrical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to magnesium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception of touch IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hippocampus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in magnesium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuronal signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in startle response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within startle response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in calyx of Held ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in juxtaparanode region of axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in juxtaparanode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in paranode region of axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in paranode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in paranode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily A member 1
    Names
    MKI
    brain potassium channel protein-1
    megencephaly
    voltage-gated potassium channel subunit Kv1.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010595.3NP_034725.3  potassium voltage-gated channel subfamily A member 1

      See identical proteins and their annotated locations for NP_034725.3

      Status: VALIDATED

      Source sequence(s)
      AC079438
      Consensus CDS
      CCDS20555.1
      UniProtKB/Swiss-Prot
      P16388
      Related
      ENSMUSP00000055225.4, ENSMUST00000055168.5
      Conserved Domains (2) summary
      cl38908
      Location:37163
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:166418
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      126613426..126622764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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