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    Rgma repulsive guidance molecule family member A [ Mus musculus (house mouse) ]

    Gene ID: 244058, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rgmaprovided by MGI
    Official Full Name
    repulsive guidance molecule family member Aprovided by MGI
    Primary source
    MGI:MGI:2679262
    See related
    Ensembl:ENSMUSG00000070509
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BC059072; C230063O06
    Expression
    Broad expression in whole brain E14.5 (RPKM 24.7), ovary adult (RPKM 23.2) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rgma in Genome Data Viewer
    Location:
    7; 7 D1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (73025268..73069647)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (73375520..73419899)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (80520406..80564785)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30075 Neighboring gene RIKEN cDNA 4930429H19 gene Neighboring gene RIKEN cDNA A730056A06 gene Neighboring gene predicted gene 44758 Neighboring gene chromodomain helicase DNA binding protein 2 Neighboring gene CRISPRi-validated cis-regulatory element for Chaserr and Chd2 Neighboring gene CHD2 adjacent suppressive regulatory RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC38550, MGC69915

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables coreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables coreceptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of axon regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of collateral sprouting ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    repulsive guidance molecule A
    Names
    RGM domain family, member A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177740.5NP_808408.2  repulsive guidance molecule A precursor

      See identical proteins and their annotated locations for NP_808408.2

      Status: VALIDATED

      Source sequence(s)
      BC059072
      Consensus CDS
      CCDS21362.2
      UniProtKB/Swiss-Prot
      Q6PCX7
      Related
      ENSMUSP00000091870.6, ENSMUST00000094312.12
      Conserved Domains (2) summary
      pfam06534
      Location:227410
      RGM_C; Repulsive guidance molecule (RGM) C-terminus
      pfam06535
      Location:48222
      RGM_N; Repulsive guidance molecule (RGM) N-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      73025268..73069647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540902.2XP_006540965.1  repulsive guidance molecule A isoform X1

      See identical proteins and their annotated locations for XP_006540965.1

      UniProtKB/Swiss-Prot
      Q6PCX7
      Related
      ENSMUSP00000145758.2, ENSMUST00000139780.3
      Conserved Domains (2) summary
      pfam06534
      Location:211389
      RGM_C; Repulsive guidance molecule (RGM) C-terminus
      pfam06535
      Location:32206
      RGM_N; Repulsive guidance molecule (RGM) N-terminus
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