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    Car7 carbonic anhydrase 7 [ Mus musculus (house mouse) ]

    Gene ID: 12354, updated on 29-May-2021

    Summary

    Official Symbol
    Car7provided by MGI
    Official Full Name
    carbonic anhydrase 7provided by MGI
    Primary source
    MGI:MGI:103100
    See related
    Ensembl:ENSMUSG00000031883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ca7; AV343731
    Expression
    Broad expression in cerebellum adult (RPKM 10.1), cortex adult (RPKM 7.5) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Car7 in Genome Data Viewer
    Location:
    8; 8 D3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105261326..105276979)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104534694..104550347)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (107064707..107074243)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene telomere repeat binding bouquet formation protein 1 Neighboring gene predicted gene, 22148 Neighboring gene NEDD8 activating enzyme E1 subunit 1 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene pyruvate dehyrogenase phosphatase catalytic subunit 2

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables hydro-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    carbonic anhydrase 7
    Names
    CA-VII
    carbonate dehydratase VII
    carbonic anhydrase VII
    NP_001288093.1
    NP_001288094.1
    NP_444300.1
    XP_006530680.1
    XP_006530681.1
    XP_030099123.1
    XP_030099124.1
    XP_036009627.1
    XP_036009628.1
    XP_036009629.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301164.1NP_001288093.1  carbonic anhydrase 7 isoform b

      See identical proteins and their annotated locations for NP_001288093.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate first exon and uses a downstream translation start site compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC130543, BC094913, BY741075
      Consensus CDS
      CCDS80920.1
      UniProtKB/Swiss-Prot
      Q9ERQ8
      UniProtKB/TrEMBL
      G3XA26
      Related
      ENSMUSP00000125112.2, ENSMUST00000159416.8
      Conserved Domains (1) summary
      cl00012
      Location:1206
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    2. NM_001301165.1NP_001288094.1  carbonic anhydrase 7 isoform b

      See identical proteins and their annotated locations for NP_001288094.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate first exon and uses a downstream translation start site compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC130543, AK144275, BC094913
      Consensus CDS
      CCDS80920.1
      UniProtKB/Swiss-Prot
      Q9ERQ8
      UniProtKB/TrEMBL
      G3XA26, Q3UND9
      Related
      ENSMUSP00000125404.2, ENSMUST00000162761.2
      Conserved Domains (1) summary
      cl00012
      Location:1206
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    3. NM_053070.3NP_444300.1  carbonic anhydrase 7 isoform a.

      See identical proteins and their annotated locations for NP_444300.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer isoform (a).
      Source sequence(s)
      AC130543
      Consensus CDS
      CCDS22581.1
      UniProtKB/Swiss-Prot
      Q9ERQ8
      Related
      ENSMUSP00000052136.5, ENSMUST00000056051.11
      Conserved Domains (1) summary
      cd03149
      Location:27262
      alpha_CA_VII; Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      105261326..105276979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153734.1XP_036009627.1  carbonic anhydrase 7 isoform X2

      Conserved Domains (1) summary
      cl00012
      Location:50232
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    2. XM_030243263.2XP_030099123.1  carbonic anhydrase 7 isoform X1

      Conserved Domains (1) summary
      cl00012
      Location:70252
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    3. XM_036153735.1XP_036009628.1  carbonic anhydrase 7 isoform X4

      Conserved Domains (1) summary
      cl00012
      Location:2158
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    4. XM_036153736.1XP_036009629.1  carbonic anhydrase 7 isoform X4

      Conserved Domains (1) summary
      cl00012
      Location:2158
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    5. XM_006530617.4XP_006530680.1  carbonic anhydrase 7 isoform X3

      See identical proteins and their annotated locations for XP_006530680.1

      UniProtKB/TrEMBL
      G3XA26
      Conserved Domains (1) summary
      cl00012
      Location:1206
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    6. XM_030243264.1XP_030099124.1  carbonic anhydrase 7 isoform X3

      Conserved Domains (1) summary
      cl00012
      Location:1206
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
    7. XM_006530618.4XP_006530681.1  carbonic anhydrase 7 isoform X3

      See identical proteins and their annotated locations for XP_006530681.1

      UniProtKB/TrEMBL
      G3XA26
      Conserved Domains (1) summary
      cl00012
      Location:1206
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
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