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    Chn1 chimerin 1 [ Mus musculus (house mouse) ]

    Gene ID: 108699, updated on 23-Jun-2021

    Summary

    Official Symbol
    Chn1provided by MGI
    Official Full Name
    chimerin 1provided by MGI
    Primary source
    MGI:MGI:1915674
    See related
    Ensembl:ENSMUSG00000056486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARH; ARHGAP2; AI413815; 0610007I19Rik; 0710001E19Rik; 1700112L09Rik; 2900046J01Rik
    Expression
    Biased expression in cortex adult (RPKM 122.5), frontal lobe adult (RPKM 81.5) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Chn1 in Genome Data Viewer
    Location:
    2; 2 C3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (73441004..73605723, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (73610660..73775367, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (73448717..73613403, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle), opposite strand Neighboring gene predicted gene, 53265 Neighboring gene chimerin 1, opposite strand 3 Neighboring gene activating transcription factor 2 Neighboring gene predicted gene 10822 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ephrin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of axonogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    N-chimaerin
    Names
    A-chimaerin
    N-chimerin
    NC
    alpha-chimerin
    alpha1 chimaerin
    alpha2 chimaerin
    alpha3-chimerin
    chimaerin
    chimerin (chimaerin) 1
    rho GTPase-activating protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113246.2NP_001106717.2  N-chimaerin isoform 3

      See identical proteins and their annotated locations for NP_001106717.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AK019340, AK032630, AK147686, BC054770, BY638589, CA749754
      Consensus CDS
      CCDS50608.1
      UniProtKB/Swiss-Prot
      Q91V57
      Related
      ENSMUSP00000107655.4, ENSMUST00000112024.10
      Conserved Domains (3) summary
      cd10352
      Location:42128
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:266459
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      pfam00130
      Location:206255
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    2. NM_001166603.1NP_001160075.1  N-chimaerin isoform 4

      See identical proteins and their annotated locations for NP_001160075.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame coding exon, as compared to variant 3. The resulting isoform (4) lacks an internal segment, as compared to isoform 3.
      Source sequence(s)
      AB264772, AK019340, AK032630, BY638589, CA749754
      Consensus CDS
      CCDS50607.1
      UniProtKB/TrEMBL
      A7VK13
      Related
      ENSMUSP00000128847.2, ENSMUST00000166199.9
      Conserved Domains (3) summary
      cd10352
      Location:42128
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      pfam00130
      Location:206237
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl02570
      Location:234401
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    3. NM_001166604.1NP_001160076.1  N-chimaerin isoform 5

      See identical proteins and their annotated locations for NP_001160076.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks multiple 5' exons and an in-frame exon in the coding region, as compared to variant 3. The resulting isoform (5) is shorter, has a distinct N-terminus and lacks an internal segment, as compared to isoform 3.
      Source sequence(s)
      AB264771, AK019340, AK032630, BY239371, BY638589
      UniProtKB/TrEMBL
      A7VK12
      Conserved Domains (2) summary
      pfam00130
      Location:81112
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl02570
      Location:109276
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    4. NM_029716.3NP_083992.1  N-chimaerin isoform 2

      See identical proteins and their annotated locations for NP_083992.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple 5' exons but has an alternate 5' exon, as compared to variant 3. The translation initiates at the downstream AUG codon and the resulting isoform (2) has a much shorter N-terminus, as compared to isoform 3.
      Source sequence(s)
      AK007182, AK019340, AK032630, BY638589
      Consensus CDS
      CCDS38145.1
      UniProtKB/Swiss-Prot
      Q91V57
      UniProtKB/TrEMBL
      A7VK14
      Related
      ENSMUSP00000070301.7, ENSMUST00000070579.7
      Conserved Domains (1) summary
      cd04372
      Location:17210
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
    5. NM_175752.3NP_786928.2  N-chimaerin isoform 1

      See identical proteins and their annotated locations for NP_786928.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks multiple 5' exons and has an alternate 5' segment, as compared to variant 3. The resulting isoform (1) is shorter and has a distinct N-terminus, as compared to isoform 3.
      Source sequence(s)
      AK019340, AK032630, AK049943, BY239371, BY638589
      Consensus CDS
      CCDS16133.1
      UniProtKB/Swiss-Prot
      Q91V57
      Related
      ENSMUSP00000099738.5, ENSMUST00000102677.11
      Conserved Domains (2) summary
      cd04372
      Location:141334
      RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
      pfam00130
      Location:81133
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      73441004..73605723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246554.2XP_030102414.1  N-chimaerin isoform X5

      Conserved Domains (2) summary
      cd04372
      Location:41234
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cl00040
      Location:132
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    2. XM_006498561.4XP_006498624.1  N-chimaerin isoform X5

      Conserved Domains (2) summary
      cd04372
      Location:41234
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cl00040
      Location:132
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    3. XM_006498557.3XP_006498620.2  N-chimaerin isoform X1

      Conserved Domains (3) summary
      cd10352
      Location:150236
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:348541
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      pfam00130
      Location:291337
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    4. XM_036157414.1XP_036013307.1  N-chimaerin isoform X5

      Conserved Domains (2) summary
      cd04372
      Location:41234
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cl00040
      Location:132
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    5. XM_036157409.1XP_036013302.1  N-chimaerin isoform X5

      Conserved Domains (2) summary
      cd04372
      Location:41234
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cl00040
      Location:132
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    6. XM_006498558.2XP_006498621.2  N-chimaerin isoform X2

      Conserved Domains (3) summary
      cd04372
      Location:336529
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      pfam00130
      Location:276325
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl15255
      Location:158198
      SH2; Src homology 2 (SH2) domain
    7. XM_030246546.1XP_030102406.1  N-chimaerin isoform X5

      Conserved Domains (2) summary
      cd04372
      Location:41234
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cl00040
      Location:132
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    8. XM_030246537.1XP_030102397.1  N-chimaerin isoform X5

      Conserved Domains (2) summary
      cd04372
      Location:41234
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cl00040
      Location:132
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    9. XM_030246534.2XP_030102394.1  N-chimaerin isoform X3

      Conserved Domains (3) summary
      cd04372
      Location:214407
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      pfam00130
      Location:154203
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl15255
      Location:176
      SH2; Src homology 2 (SH2) domain
    10. XM_030246543.1XP_030102403.1  N-chimaerin isoform X5

      Conserved Domains (2) summary
      cd04372
      Location:41234
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cl00040
      Location:132
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    11. XM_030246532.1XP_030102392.1  N-chimaerin isoform X3

      Conserved Domains (3) summary
      cd04372
      Location:214407
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      pfam00130
      Location:154203
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl15255
      Location:176
      SH2; Src homology 2 (SH2) domain
    12. XM_036157423.1XP_036013316.1  N-chimaerin isoform X5

      Conserved Domains (2) summary
      cd04372
      Location:41234
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cl00040
      Location:132
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    13. XM_006498560.4XP_006498623.1  N-chimaerin isoform X4

      Conserved Domains (2) summary
      cd04372
      Location:93286
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      pfam00130
      Location:3382
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RNA

    1. XR_004937502.1 RNA Sequence

    2. XR_004937500.1 RNA Sequence

    3. XR_004937503.1 RNA Sequence

    4. XR_003949984.2 RNA Sequence

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