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    Cd24a CD24a antigen [ Mus musculus (house mouse) ]

    Gene ID: 12484, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cd24aprovided by MGI
    Official Full Name
    CD24a antigenprovided by MGI
    Primary source
    MGI:MGI:88323
    See related
    Ensembl:ENSMUSG00000047139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H; HSA; Cd24; Ly-5; nect; Ly-52; nectadrin
    Expression
    Broad expression in liver E14.5 (RPKM 694.7), liver E14 (RPKM 640.9) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cd24a in Genome Data Viewer
    Location:
    10 B2; 10 23.01 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (43454433..43460261)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (43579169..43584265)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (43298975..43304071)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene presequence translocase associated motor 16 like Neighboring gene mitochondrial transcription rescue factor 1 Neighboring gene RIKEN cDNA F930017D23 gene Neighboring gene predicted gene, 51800 Neighboring gene ribosomal protein L26, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein tyrosine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor transport into membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell costimulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell costimulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic mitochondrial changes IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic nuclear changes IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chemokine receptor transport out of membrane raft IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glomerular parietal epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glomerular visceral epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within homotypic cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within leukocyte cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within leukocyte migration involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of T cell homeostatic proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of erythrocyte aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of erythrocyte clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inflammatory response to wounding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of monocyte chemotactic protein-1 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transforming growth factor beta3 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transforming growth factor beta3 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of B cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of T cell homeostatic proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of T cell mediated immune response to tumor cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of activated T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell-cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of inflammatory response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of integrin activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of integrin activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nephron tubule epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of neuron projection development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within pre-B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell-cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in respiratory burst ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in respiratory burst ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in response to estrogen ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in response to molecule of bacterial origin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in anchored component of external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in anchored component of external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in anchored component of external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in microvillus membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    signal transducer CD24
    Names
    M1/69-J11D heat stable antigen
    R13-Ag
    X62 heat stable antigen
    cluster of differentiation 24
    heat stable antigen
    lymphocyte antigen 52

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009846.2NP_033976.1  signal transducer CD24 precursor

      See identical proteins and their annotated locations for NP_033976.1

      Status: VALIDATED

      Source sequence(s)
      AA154829, AK014279, AK133869
      Consensus CDS
      CCDS23821.1
      UniProtKB/Swiss-Prot
      P24807
      UniProtKB/TrEMBL
      Q3THW4, Q8CEU3
      Related
      ENSMUSP00000057983.9, ENSMUST00000058714.10
      Conserved Domains (1) summary
      pfam14984
      Location:2663
      CD24; CD24 protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      43454433..43460261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155569.1XP_036011462.1  signal transducer CD24 isoform X1

      Conserved Domains (1) summary
      pfam14984
      Location:2663
      CD24; CD24 protein
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