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    Sptbn2 spectrin beta, non-erythrocytic 2 [ Mus musculus (house mouse) ]

    Gene ID: 20743, updated on 8-Jul-2021

    Summary

    Official Symbol
    Sptbn2provided by MGI
    Official Full Name
    spectrin beta, non-erythrocytic 2provided by MGI
    Primary source
    MGI:MGI:1313261
    See related
    Ensembl:ENSMUSG00000067889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sp; Spnb3
    Expression
    Biased expression in cortex adult (RPKM 49.2), frontal lobe adult (RPKM 46.9) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sptbn2 in Genome Data Viewer
    Location:
    19 A; 19 4.1 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4761236..4804006)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4711208..4753978)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (4711223..4752352)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene microRNA 6986 Neighboring gene Ras converting CAAX endopeptidase 1 Neighboring gene predicted gene 960 Neighboring gene predicted gene 21992 Neighboring gene RNA binding motif protein 4B Neighboring gene proteasome (prosome, macropain) subunit, alpha type 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0302, MGC99874

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in parallel fiber to Purkinje cell synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in parallel fiber to Purkinje cell synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in postsynaptic spectrin-associated cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic spectrin-associated cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of spectrin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    spectrin beta chain, non-erythrocytic 2
    Names
    beta-spectrin 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021287.2NP_067262.1  spectrin beta chain, non-erythrocytic 2

      See identical proteins and their annotated locations for NP_067262.1

      Status: VALIDATED

      Source sequence(s)
      AC147618, BC079860, BE993578, CJ119420
      Consensus CDS
      CCDS29434.1
      UniProtKB/TrEMBL
      Q68FG2
      Related
      ENSMUSP00000008991.7, ENSMUST00000008991.8
      Conserved Domains (5) summary
      smart00150
      Location:20182075
      SPEC; Spectrin repeats
      COG5069
      Location:51441
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:534746
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:22212326
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00435
      Location:429522
      Spectrin; Spectrin repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4761236..4804006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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