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    Tppp tubulin polymerization promoting protein [ Mus musculus (house mouse) ]

    Gene ID: 72948, updated on 23-Jun-2021

    Summary

    Official Symbol
    Tpppprovided by MGI
    Official Full Name
    tubulin polymerization promoting proteinprovided by MGI
    Primary source
    MGI:MGI:1920198
    See related
    Ensembl:ENSMUSG00000021573
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI849835; TPPP/p25; 2900041A09Rik
    Expression
    Biased expression in cortex adult (RPKM 75.7), frontal lobe adult (RPKM 53.9) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tppp in Genome Data Viewer
    Location:
    13; 13 C1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74157538..74183872)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (74009419..74035753)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (74146867..74173201)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger, DHHC domain containing 11 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene predicted gene 15912 Neighboring gene integrin linked kinase pseudogene Neighboring gene centrosomal protein 72 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 3 Neighboring gene predicted gene, 41003

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in astral microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule nucleation by microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myelin assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myelin assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oligodendrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of protein polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with microtubule bundle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tubulin polymerization-promoting protein
    Names
    25 kDa brain-specific protein
    brain-specific protein p25 alpha
    p25-alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182839.2NP_878259.1  tubulin polymerization-promoting protein

      See identical proteins and their annotated locations for NP_878259.1

      Status: VALIDATED

      Source sequence(s)
      BC054803, BM898784, BY124320
      Consensus CDS
      CCDS26638.1
      UniProtKB/Swiss-Prot
      Q7TQD2
      UniProtKB/TrEMBL
      Q3URG1
      Related
      ENSMUSP00000022057.9, ENSMUST00000022057.9
      Conserved Domains (1) summary
      pfam05517
      Location:51206
      p25-alpha

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      74157538..74183872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517409.5XP_006517472.1  tubulin polymerization-promoting protein isoform X1

      See identical proteins and their annotated locations for XP_006517472.1

      UniProtKB/Swiss-Prot
      Q7TQD2
      UniProtKB/TrEMBL
      Q3URG1
      Conserved Domains (1) summary
      pfam05517
      Location:51206
      p25-alpha
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