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    Prmt1 protein arginine N-methyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 15469, updated on 8-Jul-2021

    Summary

    Official Symbol
    Prmt1provided by MGI
    Official Full Name
    protein arginine N-methyltransferase 1provided by MGI
    Primary source
    MGI:MGI:107846
    See related
    Ensembl:ENSMUSG00000109324
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hrmt1; Mrmt1; Hrmt1l2; AW214366; 6720434D09Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 124.9), CNS E18 (RPKM 124.2) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Prmt1 in Genome Data Viewer
    Location:
    7 B3; 7 29.07 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44626179..44635844, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44976755..44986420, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (52232128..52241702, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene testis-specific serine kinase substrate Neighboring gene carnitine palmitoyltransferase 1c Neighboring gene predicted gene 15545 Neighboring gene BCL2-like 12 (proline rich) Neighboring gene interferon regulatory factor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables S-adenosyl-L-methionine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables [cytochrome c]-arginine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone methyltransferase activity (H4-R3 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone-arginine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase p38 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-arginine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-arginine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein-arginine omega-N asymmetric methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-arginine omega-N asymmetric methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-arginine omega-N monomethyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables snoRNP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H4-R3 methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H4-R3 methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone methylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-arginine methylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-arginine methylation, to asymmetrical-dimethyl arginine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptidyl-arginine omega-N-methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hemoglobin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of methylosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein arginine N-methyltransferase 1
    Names
    arginine N-methyltransferase 1
    heterogeneous nuclear ribonucleoproteins methyltransferase-like 2
    histone-arginine N-methyltransferase PRMT1
    NP_001239405.1
    NP_001239406.1
    NP_062804.1
    XP_030098017.1
    XP_030098018.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252476.1NP_001239405.1  protein arginine N-methyltransferase 1 isoform 2

      See identical proteins and their annotated locations for NP_001239405.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AI846916, AK152342, BU524421, BY760714
      Consensus CDS
      CCDS57547.1
      UniProtKB/Swiss-Prot
      Q9JIF0
      UniProtKB/TrEMBL
      Q3UIG8
      Related
      ENSMUSP00000147252.2, ENSMUST00000207370.2
      Conserved Domains (1) summary
      cd02440
      Location:74174
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001252477.1NP_001239406.1  protein arginine N-methyltransferase 1 isoform 3

      See identical proteins and their annotated locations for NP_001239406.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AI846916, AK020120, BU524421, W49313
      Consensus CDS
      CCDS85293.1
      UniProtKB/TrEMBL
      A0A140LJ70, Q9CX58
      Related
      ENSMUSP00000147101.2, ENSMUST00000207659.2
      Conserved Domains (1) summary
      cd02440
      Location:74140
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_019830.3NP_062804.1  protein arginine N-methyltransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_062804.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AF232716, AI846916, BU524421, BY760714
      Consensus CDS
      CCDS21222.1
      UniProtKB/Swiss-Prot
      Q9JIF0
      Related
      ENSMUSP00000103474.4, ENSMUST00000107843.11
      Conserved Domains (1) summary
      cd02440
      Location:92192
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. NR_045521.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI846916, BC051953, BU524421

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44626179..44635844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242158.2XP_030098018.1  protein arginine N-methyltransferase 1 isoform X2

      Conserved Domains (1) summary
      cd02440
      Location:63163
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_030242157.2XP_030098017.1  protein arginine N-methyltransferase 1 isoform X1

      Conserved Domains (1) summary
      cd02440
      Location:75175
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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