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    Atp11c ATPase, class VI, type 11C [ Mus musculus (house mouse) ]

    Gene ID: 320940, updated on 23-Jun-2021

    Summary

    Official Symbol
    Atp11cprovided by MGI
    Official Full Name
    ATPase, class VI, type 11Cprovided by MGI
    Primary source
    MGI:MGI:1859661
    See related
    Ensembl:ENSMUSG00000062949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I; Ig; AI315324; A330005H02Rik
    Expression
    Broad expression in CNS E14 (RPKM 7.2), whole brain E14.5 (RPKM 6.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Atp11c in Genome Data Viewer
    Location:
    X; X A6
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (59268643..59450041, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (60223283..60404853, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (57476467..57657156, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 5637 Neighboring gene mcf.2 transforming sequence Neighboring gene predicted gene, 22287 Neighboring gene microRNA 505 Neighboring gene predicted gene 8144 Neighboring gene predicted gene 7073

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Chemically induced (ENU) (4)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117487

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylethanolamine flippase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylserine flippase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phospholipid translocation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pre-B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    phospholipid-transporting ATPase 11C
    Names
    Atpase 11c, p type
    P4-ATPase flippase complex alpha subunit ATP11C
    probable phospholipid-transporting ATPase 11C
    NP_001001798.1
    NP_001032952.1
    NP_001345931.1
    XP_006528153.1
    XP_006528154.1
    XP_006528156.1
    XP_006528158.1
    XP_006528159.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001798.3NP_001001798.1  phospholipid-transporting ATPase 11C isoform b

      Status: VALIDATED

      Source sequence(s)
      BC106087, BY017646, CO042050, CU682339
      Consensus CDS
      CCDS40987.1
      UniProtKB/Swiss-Prot
      Q9QZW0
      UniProtKB/TrEMBL
      E9QKK8
      Related
      ENSMUSP00000033480.7, ENSMUST00000033480.13
      Conserved Domains (8) summary
      TIGR01652
      Location:401088
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:97182
      E1-E2_ATPase; E1-E2 ATPase
      pfam04547
      Location:260374
      Anoctamin; Calcium-activated chloride channel
      pfam13246
      Location:468572
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:3790
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8421089
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl14615
      Location:555674
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
      cl21460
      Location:811840
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    2. NM_001037863.2NP_001032952.1  phospholipid-transporting ATPase 11C isoform a

      See identical proteins and their annotated locations for NP_001032952.1

      Status: VALIDATED

      Source sequence(s)
      BC106087, BY017646, CO042050, CU682339
      Consensus CDS
      CCDS40988.1
      UniProtKB/Swiss-Prot
      Q9QZW0
      Related
      ENSMUSP00000099066.3, ENSMUST00000101527.3
      Conserved Domains (2) summary
      cd02073
      Location:42974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam02322
      Location:9931083
      Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II
    3. NM_001359002.1NP_001345931.1  phospholipid-transporting ATPase 11C isoform c

      Status: VALIDATED

      Source sequence(s)
      AL670778, BX284683, CO042050, CU682339
      Conserved Domains (1) summary
      cd02073
      Location:42974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      59268643..59450041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528091.5XP_006528154.1  phospholipid-transporting ATPase 11C isoform X1

      See identical proteins and their annotated locations for XP_006528154.1

      UniProtKB/Swiss-Prot
      Q9QZW0
      Conserved Domains (2) summary
      cd02073
      Location:42974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam02322
      Location:9931083
      Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II
    2. XM_006528090.5XP_006528153.1  phospholipid-transporting ATPase 11C isoform X1

      See identical proteins and their annotated locations for XP_006528153.1

      UniProtKB/Swiss-Prot
      Q9QZW0
      Conserved Domains (2) summary
      cd02073
      Location:42974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam02322
      Location:9931083
      Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II
    3. XM_006528095.4XP_006528158.1  phospholipid-transporting ATPase 11C isoform X3

      See identical proteins and their annotated locations for XP_006528158.1

      Conserved Domains (2) summary
      cd02073
      Location:42974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam02322
      Location:9931083
      Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II
    4. XM_006528093.3XP_006528156.1  phospholipid-transporting ATPase 11C isoform X2

      See identical proteins and their annotated locations for XP_006528156.1

      Conserved Domains (1) summary
      cd02073
      Location:42974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    5. XM_006528096.3XP_006528159.1  phospholipid-transporting ATPase 11C isoform X3

      See identical proteins and their annotated locations for XP_006528159.1

      Conserved Domains (2) summary
      cd02073
      Location:42974
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
      pfam02322
      Location:9931083
      Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II

    RNA

    1. XR_001782750.2 RNA Sequence

    2. XR_004940343.1 RNA Sequence

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