Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Syne1 spectrin repeat containing, nuclear envelope 1 [ Mus musculus (house mouse) ]

    Gene ID: 64009, updated on 23-Jun-2021

    Summary

    Official Symbol
    Syne1provided by MGI
    Official Full Name
    spectrin repeat containing, nuclear envelope 1provided by MGI
    Primary source
    MGI:MGI:1927152
    See related
    Ensembl:ENSMUSG00000096054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    8B; nes; CPG2; SYNE; KASH1; Myne1; enapt; myne-1; BE692247; mKIAA1756; A330049M09Rik; C130039F11Rik
    Expression
    Biased expression in cerebellum adult (RPKM 19.1), frontal lobe adult (RPKM 7.9) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Syne1 in Genome Data Viewer
    Location:
    10; 10 A1
    Exon count:
    152
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (4970192..5501013, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (5020192..5550692, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (4795849..5326349)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, pi 1 pseudogene Neighboring gene estrogen receptor 1 (alpha) Neighboring gene predicted gene, 51757 Neighboring gene predicted gene, 23573 Neighboring gene predicted gene, 40594 Neighboring gene predicted gene, 51758 Neighboring gene myc target 1 Neighboring gene vasoactive intestinal polypeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1756, MGC62825

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cytoskeleton-nuclear membrane anchor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear matrix anchoring at nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of meiotic nuclear membrane microtubule tethering complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope TAS
    Traceable Author Statement
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcomere ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    nesprin-1
    Names
    KASH domain-containing protein 1
    enaptin
    enaptin165
    myocyte nuclear envelope protein 1
    nesprin 1
    nuclear envelope spectrin repeat protein 1
    synaptic nuclear envelope 1
    synaptic nuclear envelope protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079686.1NP_001073154.1  nesprin-1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and lacks a large portion of the 5' coding region found in variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (3) is shorter and has distinct N-terminus compared to isoform 4.
      Source sequence(s)
      AC156393, AC162381, AF281870, AK041626, BC041779, BC110426
      UniProtKB/Swiss-Prot
      Q6ZWR6
      UniProtKB/TrEMBL
      Q6PI72
      Conserved Domains (4) summary
      COG4942
      Location:292549
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:22162426
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:29533009
      KASH; Nuclear envelope localization domain
      cl02488
      Location:13771565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    2. NM_001347711.1NP_001334640.1  nesprin-1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      AC156392, AC156393, AC159748, AC161829, AC162381, AC162385
    3. NM_001347732.1NP_001334661.1  nesprin-1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variants (5) differs in the 5' UTR and has multiple difference in the coding region compared variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (5) has a unique N-terminus and is shorter than isoform 4.
      Source sequence(s)
      AC156392, AC156393, AC157020, AC159748, AC161829, AC162381, AC162385
      Consensus CDS
      CCDS87951.1
      UniProtKB/TrEMBL
      A0A1L1STC6
      Related
      ENSMUSP00000150262.2, ENSMUST00000215295.2
    4. NM_022027.2NP_071310.2  nesprin-1 isoform 2

      See identical proteins and their annotated locations for NP_071310.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks a large portion of the 5' coding region compared to variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 4.
      Source sequence(s)
      AC156393, BC041779, BC054456
      Consensus CDS
      CCDS56679.1
      UniProtKB/TrEMBL
      Q0VGB8, Q6PI72, Q7TQH5
      Related
      ENSMUSP00000093587.4, ENSMUST00000095899.5
      Conserved Domains (2) summary
      cd00176
      Location:155365
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:892948
      KASH; Nuclear envelope localization domain
    5. NM_153399.2NP_700448.2  nesprin-1 isoform 1

      See identical proteins and their annotated locations for NP_700448.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in both UTRs and has multiple differences in the coding region compared to variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (1) is shorter and has distinct N- and C-termini compared to isoform 4.
      Source sequence(s)
      AC157020, AK039486, AK044459, AK122550
      Consensus CDS
      CCDS56680.1
      UniProtKB/TrEMBL
      Q6ZWR1, Q6ZWR5, Q80T95
      Related
      ENSMUSP00000039440.6, ENSMUST00000041639.7
      Conserved Domains (3) summary
      cd00014
      Location:28141
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00307
      Location:187285
      CH; Calponin homology (CH) domain
      cl02488
      Location:8421006
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      4970192..5501013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155919.1XP_036011812.1  nesprin-1 isoform X9

      Conserved Domains (9) summary
      COG0419
      Location:37924354
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28563639
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60556313
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79808190
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49445779
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:87408796
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24136
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:175283
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43264542
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    2. XM_036155938.1XP_036011831.1  nesprin-1 isoform X29

      Conserved Domains (9) summary
      COG0419
      Location:38084370
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28723655
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60676324
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79918201
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49605795
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:87288784
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24136
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:175283
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43424558
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    3. XM_036155916.1XP_036011809.1  nesprin-1 isoform X5

      Conserved Domains (9) summary
      COG0419
      Location:38084370
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28723655
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60716329
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79968206
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49605795
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:87568812
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24136
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:175283
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43424558
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    4. XM_036155917.1XP_036011810.1  nesprin-1 isoform X6

      Conserved Domains (9) summary
      COG0419
      Location:37994361
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28633646
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60626320
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79878197
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49515786
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:87478803
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43334549
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    5. XM_036155924.1XP_036011817.1  nesprin-1 isoform X16

      Conserved Domains (8) summary
      COG0419
      Location:37634325
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG4942
      Location:60266284
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79518161
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49155750
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:87118767
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:42974513
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    6. XM_036155923.1XP_036011816.1  nesprin-1 isoform X15

      Conserved Domains (9) summary
      COG0419
      Location:38154377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28793662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60276285
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79528162
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49675802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:87128768
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    7. XM_036155921.1XP_036011814.1  nesprin-1 isoform X13

      Conserved Domains (9) summary
      TIGR00618
      Location:56316278
      sbcc; exonuclease SbcC
      COG0419
      Location:38154377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28793662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79568166
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49675802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:87168772
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    8. XM_036155920.1XP_036011813.1  nesprin-1 isoform X11

      Conserved Domains (9) summary
      COG0419
      Location:38154377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28793662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60746331
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79988208
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49675802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:87358791
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    9. XM_036155915.1XP_036011808.1  nesprin-1 isoform X4

      Conserved Domains (9) summary
      COG0419
      Location:38154377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28793662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60746331
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79988208
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49675802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:87588814
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    10. XM_036155914.1XP_036011807.1  nesprin-1 isoform X3

      Conserved Domains (9) summary
      COG0419
      Location:38154377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28793662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60746332
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79998209
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49675802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:87598815
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    11. XM_036155932.1XP_036011825.1  nesprin-1 isoform X23

      Conserved Domains (8) summary
      COG1196
      Location:28793662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60786335
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80028212
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49675802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:41434439
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    12. XM_036155913.1XP_036011806.1  nesprin-1 isoform X2

      Conserved Domains (9) summary
      COG0419
      Location:38154377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28793662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60786335
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80028212
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49675802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:87628818
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    13. XM_036155931.1XP_036011824.1  nesprin-1 isoform X22

      Conserved Domains (8) summary
      COG1196
      Location:28793662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60786336
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80038213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49675802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:41434439
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    14. XM_036155925.1XP_036011818.1  nesprin-1 isoform X17

      Conserved Domains (9) summary
      COG0419
      Location:38154377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28793662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60786336
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80038213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49675802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:86928748
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    15. XM_036155922.1XP_036011815.1  nesprin-1 isoform X14

      Conserved Domains (9) summary
      COG0419
      Location:38154377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28793662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60786336
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80038213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49675802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:87158771
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    16. XM_036155927.1XP_036011820.1  nesprin-1 isoform X19

      Conserved Domains (8) summary
      COG1196
      Location:28793662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60786336
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80038213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49675802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:41434439
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    17. XM_036155918.1XP_036011811.1  nesprin-1 isoform X8

      Conserved Domains (9) summary
      COG0419
      Location:38154377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28793662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60786336
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80038213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49675802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:87408796
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    18. XM_036155926.1XP_036011819.1  nesprin-1 isoform X18

      Conserved Domains (8) summary
      COG1196
      Location:28793662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60786336
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80038213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49675802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:41434439
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    19. XM_036155912.1XP_036011805.1  nesprin-1 isoform X1

      Conserved Domains (9) summary
      COG0419
      Location:38154377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28793662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60786336
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80038213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49675802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10541
      Location:87638819
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    20. XM_036155928.1XP_036011821.1  nesprin-1 isoform X20

      Conserved Domains (8) summary
      COG1196
      Location:27473530
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:59466204
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:78718081
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:48355670
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:40114307
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam10541
      Location:86318687
      KASH; Nuclear envelope localization domain
      cd21243
      Location:50158
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:42174433
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    21. XM_036155929.1XP_036011822.1  nesprin-1 isoform X21

      Conserved Domains (8) summary
      COG1196
      Location:27313514
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:59306188
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:78558065
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:48195654
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:39954291
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam10541
      Location:86158671
      KASH; Nuclear envelope localization domain
      cd21243
      Location:50158
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:42014417
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    22. XM_011243086.3XP_011241388.1  nesprin-1 isoform X7

      Conserved Domains (10) summary
      TIGR03785
      Location:11721244
      marine_sort_HK; proteobacterial dedicated sortase system histidine kinase
      COG0419
      Location:37994361
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28633646
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60626320
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:15267
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:79878197
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49515786
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:59226099
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cl02488
      Location:43334549
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:87478803
      KASH; Nuclear envelope localization domain
    23. XM_030245204.2XP_030101064.1  nesprin-1 isoform X12

      Conserved Domains (10) summary
      TIGR03785
      Location:11561228
      marine_sort_HK; proteobacterial dedicated sortase system histidine kinase
      COG0419
      Location:37834345
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28473630
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60466304
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:15267
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:79718181
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49355770
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:59066083
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cl02488
      Location:43174533
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:87318787
      KASH; Nuclear envelope localization domain
    24. XM_036155930.1XP_036011823.1  nesprin-1 isoform X21

      Conserved Domains (8) summary
      COG1196
      Location:27313514
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:59306188
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:78558065
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:48195654
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:39954291
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam10541
      Location:86158671
      KASH; Nuclear envelope localization domain
      cd21243
      Location:50158
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:42014417
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    25. XM_017314044.3XP_017169533.1  nesprin-1 isoform X10

      Conserved Domains (10) summary
      TIGR03785
      Location:11631235
      marine_sort_HK; proteobacterial dedicated sortase system histidine kinase
      COG0419
      Location:37904352
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28543637
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60536311
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      COG5069
      Location:15274
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:79788188
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49425777
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:59136090
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cl02488
      Location:43244540
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:87388794
      KASH; Nuclear envelope localization domain
    26. XM_036155933.1XP_036011826.1  nesprin-1 isoform X24

      Conserved Domains (7) summary
      COG1196
      Location:23973180
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:55965854
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:75217731
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:44855320
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:36613957
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam10541
      Location:82818337
      KASH; Nuclear envelope localization domain
      cl02488
      Location:38674083
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    27. XM_036155934.1XP_036011827.1  nesprin-1 isoform X25

      Conserved Domains (7) summary
      COG1196
      Location:23733156
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:55725830
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:74977707
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:44615296
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:36373933
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam10541
      Location:82578313
      KASH; Nuclear envelope localization domain
      cl02488
      Location:38434059
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    28. XM_036155937.1XP_036011830.1  nesprin-1 isoform X28

      Conserved Domains (2) summary
      cd00176
      Location:155365
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:915971
      KASH; Nuclear envelope localization domain
    29. XM_036155935.1XP_036011828.1  nesprin-1 isoform X26

      Conserved Domains (7) summary
      COG1196
      Location:28793662
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG4942
      Location:60786266
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:38214011
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49675802
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    30. XM_036155936.1XP_036011829.1  nesprin-1 isoform X27

      Conserved Domains (7) summary
      COG0419
      Location:38154377
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:28793651
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:38214036
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:11672008
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:43494565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    Support Center