Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ldhb lactate dehydrogenase B [ Mus musculus (house mouse) ]

    Gene ID: 16832, updated on 31-Aug-2021

    Summary

    Official Symbol
    Ldhbprovided by MGI
    Official Full Name
    lactate dehydrogenase Bprovided by MGI
    Primary source
    MGI:MGI:96763
    See related
    Ensembl:ENSMUSG00000030246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H-Ld; Ldh-; Ldh2; H-Ldh; LDH-B; LDH-H; Ldh-2; AI790582
    Summary
    This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have also been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes 1 and 19. [provided by RefSeq, Feb 2016]
    Expression
    Broad expression in kidney adult (RPKM 644.8), heart adult (RPKM 618.4) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ldhb in Genome Data Viewer
    Location:
    6 G2; 6 74.17 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142435975..142453683, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142490249..142507957, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (142438769..142456463, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene spexin hormone Neighboring gene glycogen synthase 2 Neighboring gene predicted gene, 38919 Neighboring gene predicted gene, 46979

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables L-lactate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-lactate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lactate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in NAD metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lactate biosynthetic process from pyruvate IC
    Inferred by Curator
    more info
     
    involved_in lactate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in myelin sheath HDA PubMed 

    General protein information

    Preferred Names
    L-lactate dehydrogenase B chain
    Names
    LDH heart subunit
    lactate dehydrogenase 2, B chain
    NP_001289694.1
    NP_001303251.1
    NP_032518.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302765.1NP_001289694.1  L-lactate dehydrogenase B chain isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and a different 3' UTR compared to variant 1. The encoded isoform (2) is shorter with a distinct C-terminus compared to isoform Ldhb.
      Source sequence(s)
      AK019391, BC046755, CX208147
      UniProtKB/Swiss-Prot
      P16125
      Conserved Domains (1) summary
      cd05293
      Location:20246
      LDH_1; A subgroup of L-lactate dehydrogenases
    2. NM_001316322.1NP_001303251.1  L-lactate dehydrogenase B chain isoform Ldhbx

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (Ldhb) results from translation termination at the upstream UGA stop codon, while the longer isoform (Ldhbx) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer, C-terminally extended isoform (Ldhbx), which is localized in the peroxisomes. As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      AK019391, BC046755
      UniProtKB/Swiss-Prot
      P16125
      Related
      ENSMUSP00000159378.2, ENSMUST00000239395.2
      Conserved Domains (2) summary
      cd05293
      Location:20330
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:26326
      L-LDH-NAD; L-lactate dehydrogenase
    3. NM_008492.3NP_032518.1  L-lactate dehydrogenase B chain isoform Ldhb

      See identical proteins and their annotated locations for NP_032518.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (Ldhb) results from translation termination at the upstream UGA stop codon, while the longer isoform (Ldhbx) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (Ldhb), which is localized in the cytosol.
      Source sequence(s)
      AK019391, BC046755
      Consensus CDS
      CCDS20684.1
      UniProtKB/Swiss-Prot
      P16125
      Related
      ENSMUSP00000032373.6, ENSMUST00000032373.12
      Conserved Domains (2) summary
      cd05293
      Location:20330
      LDH_1; A subgroup of L-lactate dehydrogenases
      TIGR01771
      Location:26326
      L-LDH-NAD; L-lactate dehydrogenase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      142435975..142453683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center