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    SCML1 Scm polycomb group protein like 1 [ Homo sapiens (human) ]

    Gene ID: 6322, updated on 11-Jun-2021

    Summary

    Official Symbol
    SCML1provided by HGNC
    Official Full Name
    Scm polycomb group protein like 1provided by HGNC
    Primary source
    HGNC:HGNC:10580
    See related
    Ensembl:ENSG00000047634 MIM:300227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in testis (RPKM 14.0), ovary (RPKM 6.6) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SCML1 in Genome Data Viewer
    Location:
    Xp22.13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (17737457..17754985)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (17755613..17773105)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NHS actin remodeling regulator Neighboring gene uncharacterized LOC105373142 Neighboring gene CHP1 pseudogene 3 Neighboring gene family with sequence similarity 136 member A pseudogene Neighboring gene retinoic acid induced 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    sex comb on midleg-like protein 1
    Names
    sex comb on midleg like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037535.3NP_001032624.1  sex comb on midleg-like protein 1 isoform c

      See identical proteins and their annotated locations for NP_001032624.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons and uses an alternate splice site in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (c).
      Source sequence(s)
      AA382395, AF160728, BC026159
      Consensus CDS
      CCDS35211.1
      UniProtKB/Swiss-Prot
      Q9UN30
      UniProtKB/TrEMBL
      A0A024RBY0
      Related
      ENSP00000381154.1, ENST00000398080.5
      Conserved Domains (2) summary
      cd09578
      Location:131202
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00454
      Location:134202
      SAM; Sterile alpha motif
    2. NM_001037536.3NP_001032625.1  sex comb on midleg-like protein 1 isoform c

      See identical proteins and their annotated locations for NP_001032625.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two exons in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (c).
      Source sequence(s)
      AA382395, AF160728, BC026159
      Consensus CDS
      CCDS35211.1
      UniProtKB/Swiss-Prot
      Q9UN30
      UniProtKB/TrEMBL
      A0A024RBY0
      Related
      ENSP00000369384.3, ENST00000380045.7
      Conserved Domains (2) summary
      cd09578
      Location:131202
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00454
      Location:134202
      SAM; Sterile alpha motif
    3. NM_001037540.3NP_001032629.1  sex comb on midleg-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_001032629.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AA382395, AF160728, BC026159, BI461014
      Consensus CDS
      CCDS35210.1
      UniProtKB/Swiss-Prot
      Q9UN30
      Related
      ENSP00000369380.3, ENST00000380041.8
      Conserved Domains (2) summary
      cd09578
      Location:252323
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00454
      Location:255323
      SAM; Sterile alpha motif
    4. NM_006746.6NP_006737.2  sex comb on midleg-like protein 1 isoform b

      See identical proteins and their annotated locations for NP_006737.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AA382395, AF160728, BC026159
      Consensus CDS
      CCDS14182.2
      UniProtKB/Swiss-Prot
      Q9UN30
      UniProtKB/TrEMBL
      A0A024RBZ7
      Related
      ENSP00000369382.3, ENST00000380043.7
      Conserved Domains (2) summary
      cd09578
      Location:225296
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00454
      Location:228296
      SAM; Sterile alpha motif

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      17737457..17754985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005274578.2XP_005274635.1  sex comb on midleg-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005274635.1

      Conserved Domains (2) summary
      cd09578
      Location:253324
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00454
      Location:256324
      SAM; Sterile alpha motif
    2. XM_005274579.2XP_005274636.1  sex comb on midleg-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_005274636.1

      Conserved Domains (2) summary
      cd09578
      Location:224295
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00454
      Location:227295
      SAM; Sterile alpha motif
    3. XM_011545564.3XP_011543866.1  sex comb on midleg-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543866.1

      Conserved Domains (2) summary
      cd09578
      Location:253324
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00454
      Location:256324
      SAM; Sterile alpha motif
    4. XM_006724508.4XP_006724571.1  sex comb on midleg-like protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006724571.1

      UniProtKB/Swiss-Prot
      Q9UN30
      Conserved Domains (2) summary
      cd09578
      Location:252323
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00454
      Location:255323
      SAM; Sterile alpha motif
    5. XM_017029723.2XP_016885212.1  sex comb on midleg-like protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q9UN30
      UniProtKB/TrEMBL
      A0A024RBZ7
      Conserved Domains (2) summary
      cd09578
      Location:225296
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00454
      Location:228296
      SAM; Sterile alpha motif
    6. XM_006724509.4XP_006724572.1  sex comb on midleg-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006724572.1

      Conserved Domains (2) summary
      cd09578
      Location:224295
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00454
      Location:227295
      SAM; Sterile alpha motif
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