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    CANX calnexin [ Homo sapiens (human) ]

    Gene ID: 821, updated on 5-Sep-2021

    Summary

    Official Symbol
    CANXprovided by HGNC
    Official Full Name
    calnexinprovided by HGNC
    Primary source
    HGNC:HGNC:1473
    See related
    Ensembl:ENSG00000127022 MIM:114217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CNX; P90; IP90
    Summary
    This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2018]
    Expression
    Ubiquitous expression in thyroid (RPKM 267.4), placenta (RPKM 108.5) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CANX in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (179678646..179731641)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (179125428..179158642)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene chromosome 5 open reading frame 60-like Neighboring gene uncharacterized LOC105377763 Neighboring gene chibby family member 3 Neighboring gene high mobility group box 3 pseudogene 22 Neighboring gene mastermind like transcriptional coactivator 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A12 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Insight into genetic determinants of resting heart rate.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify calnexin (CANX), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    env The signal-sequence-retained form of HIV-1 gp120 is associated with calnexin in the endoplasmic reticulum (ER), while the signal-sequence-cleaved form is disassociated from calnexin and undergoes folding to associate with the CD4 cellular receptor PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with CANX; predicted interaction to be within the endoplasmic reticulum and function as chaperone for endoplasmic reticulum-associated degradation PubMed
    env HIV-1 Nef enhances interaction of calnexin with HIV-1 gp160, but inhibits physical interaction between calnexin and ABCA1 PubMed
    env HIV-1 gp160 domains V1/V2, C2, and the C-terminus of V3 are required for its binding to calnexin PubMed
    env HIV-1 gp160 is identified to have a physical interaction with calnexin (CANX) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    env The molecular chaperone calnexin binds to newly synthesized HIV-1 gp160; nonglycosylated gp160 is not associated with calnexin, suggesting a requirement for N-linked oligosaccharides on the newly synthesized protein for binding to occur PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify calnexin (CANX), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Knockdown of calnexin by siRNA mimics the effects of HIV-1 Nef on ABCA1 downregulation in cells PubMed
    nef HIV-1 Nef physically interacts with calnexin and co-localizes with calnexin to ER membranes in cells PubMed
    nef Tandem affinity purification and mass spectrometry analysis identify calnexin (CANX), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify calnexin (CANX), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Tat tat Expression of HIV-1 Tat upregulates the abundance of calnexin (CANX) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ26570

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables apolipoprotein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ionotropic glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in aging IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in clathrin-dependent endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein folding in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in viral protein processing TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum quality control compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    NOT located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of lumenal side of endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in integral component of postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of presynaptic active zone membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    located_in mitochondria-associated endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in smooth endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    calnexin
    Names
    epididymis secretory sperm binding protein
    major histocompatibility complex class I antigen-binding protein p88

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024649.2NP_001019820.1  calnexin isoform d precursor

      See identical proteins and their annotated locations for NP_001019820.1

      Status: REVIEWED

      Source sequence(s)
      AC113426, BC042843
      Consensus CDS
      CCDS4447.1
      UniProtKB/Swiss-Prot
      P27824
      Related
      ENSP00000391646.2, ENST00000452673.6
      Conserved Domains (1) summary
      pfam00262
      Location:71440
      Calreticulin; Calreticulin family
    2. NM_001363993.1NP_001350922.1  calnexin isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC113426
      Conserved Domains (1) summary
      pfam00262
      Location:125494
      Calreticulin; Calreticulin family
    3. NM_001363994.1NP_001350923.1  calnexin isoform b

      Status: REVIEWED

      Source sequence(s)
      AC113426, AK294702
      Conserved Domains (1) summary
      pfam00262
      Location:106475
      Calreticulin; Calreticulin family
    4. NM_001363995.1NP_001350924.1  calnexin isoform c precursor

      Status: REVIEWED

      Source sequence(s)
      AC113426
      Related
      ENSP00000506168.1, ENST00000680984.1
      Conserved Domains (1) summary
      pfam00262
      Location:71474
      Calreticulin; Calreticulin family
    5. NM_001363996.1NP_001350925.1  calnexin isoform d precursor

      Status: REVIEWED

      Source sequence(s)
      AC113426
      Related
      ENSP00000424745.2, ENST00000502296.6
      Conserved Domains (1) summary
      pfam00262
      Location:71440
      Calreticulin; Calreticulin family
    6. NM_001363997.1NP_001350926.1  calnexin isoform d precursor

      Status: REVIEWED

      Source sequence(s)
      AC113426
      Related
      ENSP00000506003.1, ENST00000681476.1
      Conserved Domains (1) summary
      pfam00262
      Location:71440
      Calreticulin; Calreticulin family
    7. NM_001363998.1NP_001350927.1  calnexin isoform e precursor

      Status: REVIEWED

      Source sequence(s)
      AC113426
      Related
      ENSP00000505470.1, ENST00000680894.1
      Conserved Domains (1) summary
      pfam00262
      Location:71440
      Calreticulin; Calreticulin family
    8. NM_001363999.1NP_001350928.1  calnexin isoform f precursor

      Status: REVIEWED

      Source sequence(s)
      AC113426
      Related
      ENSP00000506591.1, ENST00000681894.1
      Conserved Domains (1) summary
      pfam00262
      Location:71440
      Calreticulin; Calreticulin family
    9. NM_001364000.1NP_001350929.1  calnexin isoform g

      Status: REVIEWED

      Source sequence(s)
      AC113426, AK304420
      Related
      ENSP00000505129.1, ENST00000680006.1
      Conserved Domains (1) summary
      pfam00262
      Location:6332
      Calreticulin; Calreticulin family
    10. NM_001364001.1NP_001350930.1  calnexin isoform g

      Status: REVIEWED

      Source sequence(s)
      AC113426
      Related
      ENSP00000506051.1, ENST00000680827.1
      Conserved Domains (1) summary
      pfam00262
      Location:6332
      Calreticulin; Calreticulin family
    11. NM_001746.4NP_001737.1  calnexin isoform d precursor

      See identical proteins and their annotated locations for NP_001737.1

      Status: REVIEWED

      Source sequence(s)
      AC113426, BC003552
      Consensus CDS
      CCDS4447.1
      UniProtKB/Swiss-Prot
      P27824
      Related
      ENSP00000247461.4, ENST00000247461.9
      Conserved Domains (1) summary
      pfam00262
      Location:71440
      Calreticulin; Calreticulin family

    RNA

    1. NR_157048.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC113426
      Related
      ENST00000681504.1

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      179678646..179731641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534665.3XP_011532967.1  calnexin isoform X2

      See identical proteins and their annotated locations for XP_011532967.1

      UniProtKB/Swiss-Prot
      P27824
      Related
      ENSP00000505013.1, ENST00000681674.1
      Conserved Domains (1) summary
      pfam00262
      Location:71440
      Calreticulin; Calreticulin family
    2. XM_011534664.2XP_011532966.1  calnexin isoform X3

      Conserved Domains (1) summary
      pfam00262
      Location:125494
      Calreticulin; Calreticulin family

    Reference GRCh38.p13 PATCHES

    Genomic

    1. NW_016107298.1 Reference GRCh38.p13 PATCHES

      Range
      463981..497221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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