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    PTK2B protein tyrosine kinase 2 beta [ Homo sapiens (human) ]

    Gene ID: 2185, updated on 17-Oct-2021

    Summary

    Official Symbol
    PTK2Bprovided by HGNC
    Official Full Name
    protein tyrosine kinase 2 betaprovided by HGNC
    Primary source
    HGNC:HGNC:9612
    See related
    Ensembl:ENSG00000120899 MIM:601212
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK
    Summary
    This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lymph node (RPKM 29.2), bone marrow (RPKM 29.0) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PTK2B in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (27311478..27459391)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27168995..27316908)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene stathmin 4 Neighboring gene tripartite motif containing 35 Neighboring gene Sharpr-MPRA regulatory region 13363 Neighboring gene microRNA 6842 Neighboring gene cholinergic receptor nicotinic alpha 2 subunit Neighboring gene CRISPRi-validated cis-regulatory element chr8.973

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association scan of dental caries in the permanent dentition.
    GeneReviews: Not available
    Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV/tuberculosis coinfection upregulates PTK2B expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with tuberculosis only) PubMed
    Knockdown of protein tyrosine kinase 2 beta (PTK2B) by siRNA enhances HIV-1 infectivity in Jurkat cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env SMS2 is involved in HIV-1 gp120-induced phosphorylation and activation of PYK2 and polymerization of F-actin PubMed
    env Engagement of the CCR5 and CXCR4 receptors by HIV-1 gp120 induces tyrosine phosphorylation of the protein tyrosine kinase Pyk2 PubMed
    env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells PubMed
    env CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn PubMed
    env HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1 PubMed
    env Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production PubMed
    env HIV-1 gp120-induced Pyk2 activation mediated by intracellular Ca2+ release is required for HIV-1 gp120-mediated Rac-1 activation and membrane fusion PubMed
    Nef nef HIV-1 Nef expression in human T cells upregulates the levels of RAFTK activity through the SDF-1alpha signaling pathway PubMed
    Tat tat HIV-1 Tat C induces phosphorylation of PTK2B in a dose-dependent manner in human brain microvascular endothelial cells PubMed
    tat HIV-1 Tat stimulates the tyrosine phosphorylation of RAFTK and its association with paxillin, an effect mediated by the basic (amino acids 46-60) and RGD-containing (amino acids 65-80) domains of Tat and linked to AIDS-related Kaposi's sarcoma PubMed
    reverse transcriptase gag-pol Knockdown of c-Src or Pyk2 by siRNA followed by HIV-1 infection in Jurkat T-cells leads to increased reverse transcriptase activity, viral cDNA, and integrated viral genome, suggesting that c-Src and PYK2 interact with HIV-1 RT PubMed
    gag-pol HIV-1 RT is identified to have a physical interaction with protein tyrosine kinase 2 beta (PTK2B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to NMDA glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calmodulin-dependent protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein C-terminus binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activation of Janus kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in blood vessel endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone resorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular defense response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to fluid shear stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to retinoic acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chemokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endothelin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ionotropic glutamate receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in long-term synaptic depression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in marginal zone B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oocyte maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-tyrosine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-tyrosine autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of B cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of nitric-oxide synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of synaptic transmission, glutamatergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autophosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein-containing complex assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of NMDA receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of actin cytoskeleton reorganization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cGMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of establishment of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of inositol trisphosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of macrophage chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of synaptic plasticity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to immobilization stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lithium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to osmotic stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of NMDA selective glutamate receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in apical dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynaptic density TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    protein-tyrosine kinase 2-beta
    Names
    CAK-beta
    FADK 2
    PTK2B protein tyrosine kinase 2 beta
    calcium-dependent tyrosine kinase
    calcium-regulated non-receptor proline-rich tyrosine kinase
    cell adhesion kinase beta
    focal adhesion kinase 2
    proline-rich tyrosine kinase 2
    protein kinase B
    related adhesion focal tyrosine kinase
    NP_004094.3
    NP_775266.1
    NP_775267.1
    NP_775268.1
    XP_005273504.1
    XP_005273505.1
    XP_011542743.1
    XP_011542744.1
    XP_016868703.1
    XP_016868704.1
    XP_016868705.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029510.2 RefSeqGene

      Range
      4997..152905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004103.4NP_004094.3  protein-tyrosine kinase 2-beta isoform a

      See identical proteins and their annotated locations for NP_004094.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.
      Source sequence(s)
      AF311103, AL120380, AW130888, BC036651, U33284, U43522
      Consensus CDS
      CCDS6057.1
      UniProtKB/Swiss-Prot
      Q14289
      Conserved Domains (6) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00219
      Location:425679
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:150254
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:8721001
      Focal_AT; Focal adhesion targeting region
    2. NM_173174.3NP_775266.1  protein-tyrosine kinase 2-beta isoform a

      See identical proteins and their annotated locations for NP_775266.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode isoform a.
      Source sequence(s)
      AC124649, AL120380, BC036651, BM712234, BQ009032, U33284
      Consensus CDS
      CCDS6057.1
      UniProtKB/Swiss-Prot
      Q14289
      Related
      ENSP00000380638.1, ENST00000397501.5
      Conserved Domains (6) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00219
      Location:425679
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:150254
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:8721001
      Focal_AT; Focal adhesion targeting region
    3. NM_173175.2NP_775267.1  protein-tyrosine kinase 2-beta isoform b

      See identical proteins and their annotated locations for NP_775267.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
      Source sequence(s)
      AF311103, AL120380, AW130888, BC036651, U33284
      Consensus CDS
      CCDS6058.1
      UniProtKB/Swiss-Prot
      Q14289
      Related
      ENSP00000391995.2, ENST00000420218.3
      Conserved Domains (6) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00219
      Location:425679
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:150254
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:830959
      Focal_AT; Focal adhesion targeting region
    4. NM_173176.3NP_775268.1  protein-tyrosine kinase 2-beta isoform a

      See identical proteins and their annotated locations for NP_775268.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.
      Source sequence(s)
      AF311103, AL120380, AW130888, BC042599, U33284
      Consensus CDS
      CCDS6057.1
      UniProtKB/Swiss-Prot
      Q14289
      Related
      ENSP00000332816.6, ENST00000346049.10
      Conserved Domains (6) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00219
      Location:425679
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:150254
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:8721001
      Focal_AT; Focal adhesion targeting region

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      27311478..27459391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013214.1XP_016868703.1  protein-tyrosine kinase 2-beta isoform X1

      UniProtKB/Swiss-Prot
      Q14289
      Conserved Domains (6) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00219
      Location:425679
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:150254
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:8721001
      Focal_AT; Focal adhesion targeting region
    2. XM_005273448.5XP_005273505.1  protein-tyrosine kinase 2-beta isoform X2

      Conserved Domains (6) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00219
      Location:425679
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:150254
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:860989
      Focal_AT; Focal adhesion targeting region
    3. XM_011544442.3XP_011542744.1  protein-tyrosine kinase 2-beta isoform X3

      Conserved Domains (6) summary
      cd05056
      Location:405674
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00219
      Location:412666
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261355
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:150254
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:859988
      Focal_AT; Focal adhesion targeting region
    4. XM_017013216.2XP_016868705.1  protein-tyrosine kinase 2-beta isoform X4

    5. XM_011544441.2XP_011542743.1  protein-tyrosine kinase 2-beta isoform X1

      See identical proteins and their annotated locations for XP_011542743.1

      UniProtKB/Swiss-Prot
      Q14289
      Conserved Domains (6) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00219
      Location:425679
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:150254
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:8721001
      Focal_AT; Focal adhesion targeting region
    6. XM_017013215.1XP_016868704.1  protein-tyrosine kinase 2-beta isoform X3

      Conserved Domains (6) summary
      cd05056
      Location:405674
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00219
      Location:412666
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261355
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:150254
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:859988
      Focal_AT; Focal adhesion targeting region
    7. XM_005273447.4XP_005273504.1  protein-tyrosine kinase 2-beta isoform X1

      See identical proteins and their annotated locations for XP_005273504.1

      UniProtKB/Swiss-Prot
      Q14289
      Conserved Domains (6) summary
      cd05056
      Location:418687
      PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
      smart00219
      Location:425679
      TyrKc; Tyrosine kinase, catalytic domain
      smart00295
      Location:41254
      B41; Band 4.1 homologues
      cd13190
      Location:261368
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cd14473
      Location:150254
      FERM_B-lobe; FERM domain B-lobe
      pfam03623
      Location:8721001
      Focal_AT; Focal adhesion targeting region
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