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    PNOC prepronociceptin [ Homo sapiens (human) ]

    Gene ID: 5368, updated on 3-Oct-2021

    Summary

    Official Symbol
    PNOCprovided by HGNC
    Official Full Name
    prepronociceptinprovided by HGNC
    Primary source
    HGNC:HGNC:9163
    See related
    Ensembl:ENSG00000168081 MIM:601459
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOP; OFQ; N/OFQ; PPNOC; ppN/OFQ
    Summary
    This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015]
    Expression
    Biased expression in brain (RPKM 7.7), lymph node (RPKM 5.0) and 8 other tissues See more
    Orthologs
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    Genomic context

    See PNOC in Genome Data Viewer
    Location:
    8p21.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (28316979..28343355)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (28174785..28200868)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene PDZ and LIM domain 7 (enigma) pseudogene Neighboring gene ribosomal protein L5 pseudogene 22 Neighboring gene zinc finger protein 395 Neighboring gene RNA, U6 small nuclear 178, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables neuropeptide hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables opioid peptide activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables opioid receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in sensory perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    prepronociceptin
    Names
    nociceptin
    nocistatin
    orphanin FQ
    pre-pro-N/OFQ
    pronociceptin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284244.2NP_001271173.1  prepronociceptin isoform 2

      See identical proteins and their annotated locations for NP_001271173.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (2) lacks a signal peptide sequence and has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC021678, BF976583, CA412176
      Consensus CDS
      CCDS64862.1
      UniProtKB/Swiss-Prot
      Q13519
      Related
      ENSP00000430145.1, ENST00000522209.1
    2. NM_006228.5NP_006219.1  prepronociceptin isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_006219.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC021678, BC034758
      Consensus CDS
      CCDS6066.1
      UniProtKB/Swiss-Prot
      Q13519
      Related
      ENSP00000301908.3, ENST00000301908.8
      Conserved Domains (1) summary
      pfam01160
      Location:2266
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      28316979..28343355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544559.2XP_011542861.1  prepronociceptin isoform X1

      See identical proteins and their annotated locations for XP_011542861.1

      Conserved Domains (1) summary
      pfam01160
      Location:2265
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    2. XM_005273532.2XP_005273589.1  prepronociceptin isoform X1

      See identical proteins and their annotated locations for XP_005273589.1

      Conserved Domains (1) summary
      pfam01160
      Location:2265
      Opiods_neuropep; Vertebrate endogenous opioids neuropeptide
    3. XM_017013578.1XP_016869067.1  prepronociceptin isoform X2

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