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    ADRA1A adrenoceptor alpha 1A [ Homo sapiens (human) ]

    Gene ID: 148, updated on 22-Aug-2021

    Summary

    Official Symbol
    ADRA1Aprovided by HGNC
    Official Full Name
    adrenoceptor alpha 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:277
    See related
    Ensembl:ENSG00000120907 MIM:104221
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADRA1C; ADRA1L1; ALPHA1AAR
    Summary
    Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in fat (RPKM 3.7), liver (RPKM 3.6) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADRA1A in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (26738113..26870994, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (26605667..26724795, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene PNMA family member 2 Neighboring gene dihydropyrimidinase like 2 Neighboring gene proteasome activator subunit 2 pseudogene 5 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 9 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 4 Neighboring gene uncharacterized LOC105379339 Neighboring gene protein phosphatase 4 regulatory subunit 3B pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    An atlas of genetic influences on human blood metabolites.
    GeneReviews: Not available
    Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables alpha1-adrenergic receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables alpha1-adrenergic receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables alpha1-adrenergic receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables alpha1-adrenergic receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in activation of phospholipase C activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in adult heart development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in aging ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in calcium ion transport into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell growth involved in cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in micturition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron-glial cell signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in pilomotor reflex IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cardiac muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cardiac muscle hypertrophy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of heart rate by epinephrine-norepinephrine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein kinase C signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of synaptic transmission, GABAergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vasoconstriction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of vasoconstriction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to xenobiotic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in smooth muscle contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in T-tubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in dopaminergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    alpha-1A adrenergic receptor
    Names
    G protein coupled receptor
    alpha-1A adrenoceptor
    alpha-1A adrenoreceptor
    alpha-1C adrenergic receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029395.1 RefSeqGene

      Range
      4751..122256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000680.4NP_000671.2  alpha-1A adrenergic receptor isoform 1

      See identical proteins and their annotated locations for NP_000671.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is alternatively spliced in the 3' end, compared to variant 3. It encodes isoform 1, which has a longer and distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AA383170, AC022839, AC091675, AK289548, AK311558, BF475837, D25235, HY277084
      Consensus CDS
      CCDS6054.1
      UniProtKB/Swiss-Prot
      P35348
      Related
      ENSP00000369947.3, ENST00000380573.4
      Conserved Domains (2) summary
      pfam00001
      Location:43326
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:37341
      7tm_4; Olfactory receptor
    2. NM_001322502.1NP_001309431.1  alpha-1A adrenergic receptor isoform 5

      Status: REVIEWED

      Source sequence(s)
      AA568306, AC015564, AC022839, AK289548, AK311558, AY491778, BX101935
      UniProtKB/Swiss-Prot
      P35348
      Conserved Domains (2) summary
      pfam00001
      Location:43300
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:37224
      7tm_4; Olfactory receptor
    3. NM_001322503.1NP_001309432.1  alpha-1A adrenergic receptor isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC015564, AC022839, AK289548, AK311558, D32202
      UniProtKB/Swiss-Prot
      P35348
      Conserved Domains (3) summary
      pfam00001
      Location:43303
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam13900
      Location:300339
      GVQW; Putative domain of unknown function
      cl21561
      Location:37224
      7tm_4; Olfactory receptor
    4. NM_001322504.1NP_001309433.1  alpha-1A adrenergic receptor isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC022839, AC091675, AK289548, AK311558, AY491781
      Consensus CDS
      CCDS83269.1
      UniProtKB/Swiss-Prot
      P35348
      Related
      ENSP00000369946.3, ENST00000380572.3
      Conserved Domains (2) summary
      pfam00001
      Location:43295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:37224
      7tm_4; Olfactory receptor
    5. NM_033302.3NP_150645.2  alpha-1A adrenergic receptor isoform 3

      See identical proteins and their annotated locations for NP_150645.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform 3.
      Source sequence(s)
      AA568306, AC015564, AC022839, AC091675, AK289548, AK311558, BX101935, D32201
      Consensus CDS
      CCDS6052.1
      UniProtKB/Swiss-Prot
      P35348
      Related
      ENSP00000369956.3, ENST00000380582.7
      Conserved Domains (2) summary
      pfam00001
      Location:43326
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:37341
      7tm_4; Olfactory receptor
    6. NM_033303.4NP_150646.3  alpha-1A adrenergic receptor isoform 2

      See identical proteins and their annotated locations for NP_150646.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate 3' terminal exon, compared to variant 3. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 3.
      Source sequence(s)
      AC015564, AC022839, AC091675, AK289548, AK311558, D32202
      Consensus CDS
      CCDS34869.1
      UniProtKB/Swiss-Prot
      P35348
      UniProtKB/TrEMBL
      B0ZBD3
      Related
      ENSP00000369960.1, ENST00000380586.5
      Conserved Domains (2) summary
      pfam00001
      Location:43326
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:37341
      7tm_4; Olfactory receptor
    7. NM_033304.3NP_150647.2  alpha-1A adrenergic receptor isoform 4

      See identical proteins and their annotated locations for NP_150647.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) includes an alternate 3' terminal exon, compared to variant 3. It encodes isoform 4, which has a longer and distinct C-terminus, compared to isoform 3.
      Source sequence(s)
      AC022839, AC091675, AF013261, AK289548, AK311558, D32201
      Consensus CDS
      CCDS6053.1
      UniProtKB/Swiss-Prot
      P35348
      Related
      ENSP00000346557.4, ENST00000354550.4
      Conserved Domains (2) summary
      pfam00001
      Location:43326
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:37341
      7tm_4; Olfactory receptor

    RNA

    1. NR_136343.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC015564, AC022839, AK289548, AK311558, AY491775, D32202

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      26738113..26870994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013094.1XP_016868583.1  alpha-1A adrenergic receptor isoform X1

      UniProtKB/TrEMBL
      B0ZBD3
      Conserved Domains (2) summary
      pfam00001
      Location:43326
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:37341
      7tm_4; Olfactory receptor
    2. XM_017013095.1XP_016868584.1  alpha-1A adrenergic receptor isoform X1

      UniProtKB/TrEMBL
      B0ZBD3
      Conserved Domains (2) summary
      pfam00001
      Location:43326
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:37341
      7tm_4; Olfactory receptor
    3. XM_006716292.3XP_006716355.1  alpha-1A adrenergic receptor isoform X1

      See identical proteins and their annotated locations for XP_006716355.1

      UniProtKB/TrEMBL
      B0ZBD3
      Conserved Domains (2) summary
      pfam00001
      Location:43326
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:37341
      7tm_4; Olfactory receptor
    4. XM_006716293.4XP_006716356.1  alpha-1A adrenergic receptor isoform X2

      See identical proteins and their annotated locations for XP_006716356.1

      UniProtKB/Swiss-Prot
      P35348
      Conserved Domains (2) summary
      pfam00001
      Location:43326
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:37341
      7tm_4; Olfactory receptor
    5. XM_017013096.1XP_016868585.1  alpha-1A adrenergic receptor isoform X4

    6. XM_011544412.3XP_011542714.1  alpha-1A adrenergic receptor isoform X5

      Conserved Domains (2) summary
      pfam00001
      Location:43295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:37224
      7tm_4; Olfactory receptor
    7. XM_011544411.2XP_011542713.1  alpha-1A adrenergic receptor isoform X3

      See identical proteins and their annotated locations for XP_011542713.1

      UniProtKB/Swiss-Prot
      P35348
      Related
      ENSP00000430414.1, ENST00000521711.5
      Conserved Domains (2) summary
      pfam00001
      Location:43298
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:37224
      7tm_4; Olfactory receptor

    RNA

    1. XR_001745477.1 RNA Sequence

    2. XR_001745476.1 RNA Sequence

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