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    STMN4 stathmin 4 [ Homo sapiens (human) ]

    Gene ID: 81551, updated on 5-Sep-2021

    Summary

    Official Symbol
    STMN4provided by HGNC
    Official Full Name
    stathmin 4provided by HGNC
    Primary source
    HGNC:HGNC:16078
    See related
    Ensembl:ENSG00000015592
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RB3
    Expression
    Restricted expression toward brain (RPKM 50.0) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See STMN4 in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (27235308..27258865, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27092825..27115921, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microRNA 548h-4 Neighboring gene uncharacterized LOC105379340 Neighboring gene tripartite motif containing 35 Neighboring gene protein tyrosine kinase 2 beta Neighboring gene Sharpr-MPRA regulatory region 13363

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC111012

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    stathmin-4
    Names
    stathmin-like 4
    stathmin-like protein B3
    stathmin-like-protein RB3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001283053.2NP_001269982.1  stathmin-4 isoform 2

      See identical proteins and their annotated locations for NP_001269982.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC090150, AI638208, AK297415
      Consensus CDS
      CCDS64854.1
      UniProtKB/Swiss-Prot
      Q9H169
      Related
      ENSP00000428428.1, ENST00000523048.5
      Conserved Domains (1) summary
      pfam00836
      Location:76203
      Stathmin; Stathmin family
    2. NM_001283054.2NP_001269983.1  stathmin-4 isoform 3

      See identical proteins and their annotated locations for NP_001269983.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 3 which is shorter compared to isoform 1.
      Source sequence(s)
      AC090150, AI638208, BC111001
      Consensus CDS
      CCDS64852.1
      UniProtKB/Swiss-Prot
      Q9H169
      Related
      ENSP00000265770.7, ENST00000265770.11
      Conserved Domains (1) summary
      pfam00836
      Location:49184
      Stathmin; Stathmin family
    3. NM_001283055.2NP_001269984.1  stathmin-4 isoform 4

      See identical proteins and their annotated locations for NP_001269984.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in both UTR's and the coding region , compared to variant 1. This results in an isoform (4) that is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC090150, AI638208, AK295329
      Consensus CDS
      CCDS64851.1
      UniProtKB/Swiss-Prot
      Q9H169
      Related
      ENSP00000428474.1, ENST00000519997.5
      Conserved Domains (1) summary
      pfam00836
      Location:40167
      Stathmin; Stathmin family
    4. NM_001394383.1NP_001381312.1  stathmin-4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC090150
      Conserved Domains (1) summary
      pfam00836
      Location:48183
      Stathmin; Stathmin family
    5. NM_001394384.1NP_001381313.1  stathmin-4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC090150
      Conserved Domains (1) summary
      pfam00836
      Location:40175
      Stathmin; Stathmin family
    6. NM_001394385.1NP_001381314.1  stathmin-4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC090150
      Conserved Domains (1) summary
      pfam00836
      Location:49176
      Stathmin; Stathmin family
    7. NM_001394386.1NP_001381315.1  stathmin-4 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC090150
      Conserved Domains (1) summary
      pfam00836
      Location:17152
      Stathmin; Stathmin family
    8. NM_001394387.1NP_001381316.1  stathmin-4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC090150
    9. NM_001394388.1NP_001381317.1  stathmin-4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC090150
    10. NM_030795.4NP_110422.2  stathmin-4 isoform 1

      See identical proteins and their annotated locations for NP_110422.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC090150, AI638208, BC011520
      Consensus CDS
      CCDS6055.1
      UniProtKB/Swiss-Prot
      Q9H169
      Related
      ENSP00000342538.4, ENST00000350889.8
      Conserved Domains (1) summary
      pfam00836
      Location:76211
      Stathmin; Stathmin family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      27235308..27258865 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005273652.4XP_005273709.1  stathmin-4 isoform X1

      UniProtKB/TrEMBL
      E7EVN3
      Related
      ENSP00000430389.1, ENST00000522908.1
      Conserved Domains (1) summary
      pfam00836
      Location:80201
      Stathmin; Stathmin family

    RNA

    1. XR_002956647.1 RNA Sequence

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