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    Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 [ Mus musculus (house mouse) ]

    Gene ID: 81489, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dnajb1provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B1provided by MGI
    Primary source
    MGI:MGI:1931874
    See related
    Ensembl:ENSMUSG00000005483
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hsp; DjB1; Hdj1; HSPF1; Hsp40; 0610007I11Rik
    Summary
    This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. The encoded protein may also inhibit apoptosis. Peritoneal macrophages derived from homozygous knockout mice for this gene exhibit impaired heat tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in testis adult (RPKM 83.7), thymus adult (RPKM 27.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dnajb1 in Genome Data Viewer
    Location:
    8; 8 C2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84334804..84339282)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83608175..83612653)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (86132074..86135802)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D830024N08 gene Neighboring gene trans-2,3-enoyl-CoA reductase Neighboring gene predicted gene, 51541 Neighboring gene predicted gene, 42029 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene GIPC PDZ domain containing family, member 1 Neighboring gene prostaglandin E receptor 1 (subtype EP1) Neighboring gene protein kinase N1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm head ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily B member 1
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 1
    heat shock 40 kDa protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308227.1NP_001295156.1  dnaJ homolog subfamily B member 1 isoform 2

      See identical proteins and their annotated locations for NP_001295156.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon, resulting in a distinct 5' UTR and the use of an in-frame downstream start site, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AA794374, AC151992, AK158530, BY476619, BY658568
      Consensus CDS
      CCDS85571.1
      UniProtKB/TrEMBL
      Q3TYL7
      Related
      ENSMUSP00000148685.2, ENSMUST00000212300.2
      Conserved Domains (1) summary
      cd10747
      Location:62226
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    2. NM_018808.3NP_061278.1  dnaJ homolog subfamily B member 1 isoform 1

      See identical proteins and their annotated locations for NP_061278.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA794374, AC151992, AK146657, BY251864, BY476619, BY658568
      Consensus CDS
      CCDS22456.1
      UniProtKB/Swiss-Prot
      Q9QYJ3
      UniProtKB/TrEMBL
      Q3TU79
      Related
      ENSMUSP00000005620.9, ENSMUST00000005620.10
      Conserved Domains (3) summary
      cd10747
      Location:162326
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:1340
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:465
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      84334804..84339282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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