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    Ndufs4 NADH:ubiquinone oxidoreductase core subunit S4 [ Mus musculus (house mouse) ]

    Gene ID: 17993, updated on 6-Jul-2021

    Summary

    Official Symbol
    Ndufs4provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase core subunit S4provided by MGI
    Primary source
    MGI:MGI:1343135
    See related
    Ensembl:ENSMUSG00000021764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C1-18k; 6720411N02Rik
    Expression
    Ubiquitous expression in heart adult (RPKM 45.1), CNS E18 (RPKM 31.6) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ndufs4 in Genome Data Viewer
    Location:
    13; 13 D2.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (114424331..114524630, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (114287795..114388094, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (115078003..115178302, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 15 Neighboring gene RIKEN cDNA A430090L17 gene Neighboring gene predicted gene, 41072 Neighboring gene predicted gene, 41073 Neighboring gene predicted gene, 41074 Neighboring gene follistatin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within adult walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular respiration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to oxygen levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in electron transport chain IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrial respiratory chain complex I assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within psychomotor behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of mitochondrial membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within respiratory electron transport chain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within respiratory system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to cAMP ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to injury involved in regulation of muscle adaptation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within tricarboxylic acid cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within visual perception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of mitochondrial respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of mitochondrial respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of mitochondrial respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in respirasome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
    Names
    CI-18 kDa
    CI-AQDQ
    NADH-ubiquinone oxidoreductase 18 kDa subunit
    complex I-18 kDa
    complex I-AQDQ

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010887.2NP_035017.2  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      AK011124, AK035175, CJ041886, CJ073528
      Consensus CDS
      CCDS49368.1
      UniProtKB/Swiss-Prot
      Q9CXZ1
      UniProtKB/TrEMBL
      E9QPX3
      Related
      ENSMUSP00000022286.7, ENSMUST00000022286.8
      Conserved Domains (1) summary
      pfam04800
      Location:76170
      ETC_C1_NDUFA4; ETC complex I subunit conserved region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      114424331..114524630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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