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    Ltc4s leukotriene C4 synthase [ Mus musculus (house mouse) ]

    Gene ID: 17001, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ltc4sprovided by MGI
    Official Full Name
    leukotriene C4 synthaseprovided by MGI
    Primary source
    MGI:MGI:107498
    See related
    Ensembl:ENSMUSG00000020377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    The protein encoded by this gene is an enzyme that catalyzes the synthesis of leukotriene C4 by combining leukotriene A4 with reduced glutathione. The encoded protein is found in the outer nuclear membrane and in the peripheral endoplasmic reticulum. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as bronchial asthma in humans. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 93.5), mammary gland adult (RPKM 76.1) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ltc4s in Genome Data Viewer
    Location:
    11; 11 B1.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50127288..50129378, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50236461..50238532, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (50049974..50051973, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36556 Neighboring gene mannoside acetylglucosaminyltransferase 4, isoenzyme B Neighboring gene microRNA 6919 Neighboring gene mastermind like transcriptional coactivator 1 Neighboring gene calnexin Neighboring gene predicted gene, 46280

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables leukotriene-C4 synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables leukotriene-C4 synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables leukotriene-C4 synthase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    leukotriene C4 synthase
    Names
    LTC4 synthase
    glutathione S-transferase LTC4
    leukotriene-C(4) synthase
    NP_001300897.1
    NP_032547.1
    XP_036012258.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313968.1NP_001300897.1  leukotriene C4 synthase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC028760, BC038518, BE848671
      Consensus CDS
      CCDS83799.1
      UniProtKB/TrEMBL
      Q8K355
      Related
      ENSMUSP00000098823.3, ENSMUST00000101265.9
      Conserved Domains (1) summary
      pfam01124
      Location:8105
      MAPEG; MAPEG family
    2. NM_008521.2NP_032547.1  leukotriene C4 synthase isoform 1

      See identical proteins and their annotated locations for NP_032547.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC038518, BE848671, U27195
      Consensus CDS
      CCDS24631.1
      UniProtKB/Swiss-Prot
      Q60860
      Related
      ENSMUSP00000099833.4, ENSMUST00000102772.4
      Conserved Domains (1) summary
      pfam01124
      Location:8124
      MAPEG; MAPEG family

    RNA

    1. NR_132732.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate internal splice junction compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      BC038518, BE848671
      Related
      ENSMUST00000125555.2
    2. NR_132733.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses two alternate internal splice junctions compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      BC038518, BE848671, BE852852
      Related
      ENSMUST00000221525.2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      50127288..50129378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156365.1XP_036012258.1  leukotriene C4 synthase isoform X1

      Conserved Domains (1) summary
      pfam01124
      Location:45126
      MAPEG; MAPEG family
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