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    Sik2 salt inducible kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 235344, updated on 5-Sep-2021

    Summary

    Official Symbol
    Sik2provided by MGI
    Official Full Name
    salt inducible kinase 2provided by MGI
    Primary source
    MGI:MGI:2445031
    See related
    Ensembl:ENSMUSG00000037112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Snf1; Snf1lk2; G630080D20Rik
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 39.2), mammary gland adult (RPKM 30.6) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sik2 in Genome Data Viewer
    Location:
    9; 9 A5.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50800944..50920432, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50889644..51009132, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (50700906..50817178, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase) Neighboring gene protein phosphatase 2, regulatory subunit A, beta Neighboring gene predicted gene, 25558 Neighboring gene predicted gene, 32681 Neighboring gene layilin Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene microRNA 34c Neighboring gene BTG anti-proliferation factor 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase SIK2
    Names
    SIK-2
    SNF1-like kinase 2
    salt induceable kinase 2
    salt-inducible protein kinase 2
    serine/threonine-protein kinase SNF1-like kinase 2
    NP_848825.2
    XP_006510329.1
    XP_006510330.1
    XP_017168821.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178710.3NP_848825.2  serine/threonine-protein kinase SIK2

      See identical proteins and their annotated locations for NP_848825.2

      Status: VALIDATED

      Source sequence(s)
      AB067780, AI605180, AK090386, BB635920
      Consensus CDS
      CCDS40627.1
      UniProtKB/Swiss-Prot
      Q8CFH6
      UniProtKB/TrEMBL
      F8VPT7
      Related
      ENSMUSP00000038761.11, ENSMUST00000041375.11
      Conserved Domains (3) summary
      smart00220
      Location:20271
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14409
      Location:297341
      UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
      cd14071
      Location:19271
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      50800944..50920432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510267.3XP_006510330.1  serine/threonine-protein kinase SIK2 isoform X2

      Conserved Domains (2) summary
      cd14409
      Location:297341
      UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
      cd14071
      Location:19271
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
    2. XM_017313332.3XP_017168821.1  serine/threonine-protein kinase SIK2 isoform X3

      Conserved Domains (2) summary
      cd14409
      Location:297341
      UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
      cd14071
      Location:19271
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
    3. XM_006510266.3XP_006510329.1  serine/threonine-protein kinase SIK2 isoform X1

      UniProtKB/TrEMBL
      H3BKG1
      Related
      ENSMUSP00000135376.2, ENSMUST00000176663.8
      Conserved Domains (2) summary
      cd14409
      Location:297341
      UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
      cd14071
      Location:19271
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

    RNA

    1. XR_379116.2 RNA Sequence

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