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    Csn2 casein beta [ Mus musculus (house mouse) ]

    Gene ID: 12991, updated on 23-Jun-2021

    Summary

    Official Symbol
    Csn2provided by MGI
    Official Full Name
    casein betaprovided by MGI
    Primary source
    MGI:MGI:88541
    See related
    Ensembl:ENSMUSG00000063157
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CS; Csnb
    Expression
    Restricted expression toward thymus adult (RPKM 9.8) See more
    Orthologs
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    Try the new Transcript table

    Genomic context

    See Csn2 in Genome Data Viewer
    Location:
    5 E1; 5 43.56 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (87840478..87847288, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (87692619..87699429, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (88121649..88128446, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene pleckstrin and Sec7 domain containing 3 pseudogene Neighboring gene casein alpha s1 Neighboring gene predicted gene, 25066 Neighboring gene predicted gene, 24314

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in lactation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286020.1NP_001272949.1  beta-casein isoform b precursor

      See identical proteins and their annotated locations for NP_001272949.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AC074046, AK085698
      Consensus CDS
      CCDS80317.1
      UniProtKB/Swiss-Prot
      P10598
      UniProtKB/TrEMBL
      Q8BGL0
      Related
      ENSMUSP00000080976.7, ENSMUST00000082370.10
      Conserved Domains (1) summary
      pfam00363
      Location:143218
      Casein; Casein
    2. NM_001286021.1NP_001272950.1  beta-casein isoform b precursor

      See identical proteins and their annotated locations for NP_001272950.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AC074046, AK085698
      Consensus CDS
      CCDS80317.1
      UniProtKB/Swiss-Prot
      P10598
      UniProtKB/TrEMBL
      Q8BGL0
      Related
      ENSMUSP00000143709.2, ENSMUST00000198057.5
      Conserved Domains (1) summary
      pfam00363
      Location:143218
      Casein; Casein
    3. NM_001286022.1NP_001272951.1  beta-casein isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC074046, AK085698
      UniProtKB/TrEMBL
      Q8BGL0
      Related
      ENSMUSP00000142673.2, ENSMUST00000196163.2
      Conserved Domains (1) summary
      pfam00363
      Location:135210
      Casein; Casein
    4. NM_001286023.1NP_001272952.1  beta-casein isoform d precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
      Source sequence(s)
      AC074046, AK052805
      UniProtKB/Swiss-Prot
      P10598
      Conserved Domains (1) summary
      pfam00363
      Location:129204
      Casein; Casein
    5. NM_001286024.1NP_001272953.1  beta-casein isoform e precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate in-frame exons in the 5' coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
      Source sequence(s)
      AC074046, AK085698
      Consensus CDS
      CCDS80315.1
      UniProtKB/TrEMBL
      A0A0G2JF04, Q8BGL0
      Related
      ENSMUSP00000142971.2, ENSMUST00000196869.5
      Conserved Domains (1) summary
      pfam00363
      Location:128203
      Casein; Casein
    6. NM_009972.2NP_034102.1  beta-casein isoform a precursor

      See identical proteins and their annotated locations for NP_034102.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC074046, AK052805
      Consensus CDS
      CCDS39131.1
      UniProtKB/Swiss-Prot
      P10598
      Related
      ENSMUSP00000143341.2, ENSMUST00000197422.5
      Conserved Domains (1) summary
      pfam00363
      Location:144219
      Casein; Casein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      87840478..87847288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_389259.2 RNA Sequence

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