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    Pla2g15 phospholipase A2, group XV [ Mus musculus (house mouse) ]

    Gene ID: 192654, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pla2g15provided by MGI
    Official Full Name
    phospholipase A2, group XVprovided by MGI
    Primary source
    MGI:MGI:2178076
    See related
    Ensembl:ENSMUSG00000031903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L; Ly; ACS; LLPL; Lpla2; C87498; Lypla3
    Expression
    Ubiquitous expression in spleen adult (RPKM 14.2), subcutaneous fat pad adult (RPKM 13.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pla2g15 in Genome Data Viewer
    Location:
    8; 8 D3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106876986..106891350)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106150354..106164718)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (108674299..108688615)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Neighboring gene RIKEN cDNA 1810019D21 gene Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 Neighboring gene solute carrier family 7, member 6 opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acylglycerol O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-independent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium-independent phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-independent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables lysophospholipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidyl phospholipase B activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylserine 1-acylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A1 activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipase A1 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ceramide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within ceramide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ceramide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ceramide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in diacylglycerol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glycerophospholipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycerophospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidylcholine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylcholine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylcholine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidylcholine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylethanolamine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylethanolamine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylserine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phospholipase A2 group XV
    Names
    1-O-acylceramide synthase
    LCAT-like lysophospholipase
    group XV phospholipase A2
    lysophospholipase 3
    lysosomal phospholipase A and acyltransferase
    lysosomal phospholipase A2
    NP_001344248.1
    NP_598553.1
    XP_036009728.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357319.1NP_001344248.1  phospholipase A2 group XV isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC133195, AK028614, BM226964
      Consensus CDS
      CCDS90455.1
      Related
      ENSMUSP00000148565.2, ENSMUST00000212963.2
      Conserved Domains (1) summary
      cl21494
      Location:84167
      Abhydrolase; alpha/beta hydrolases
    2. NM_133792.3NP_598553.1  phospholipase A2 group XV isoform 1 precursor

      See identical proteins and their annotated locations for NP_598553.1

      Status: VALIDATED

      Source sequence(s)
      AC133195, AK085194, BM226964
      Consensus CDS
      CCDS22630.1
      UniProtKB/Swiss-Prot
      Q8VEB4
      Related
      ENSMUSP00000034377.7, ENSMUST00000034377.8
      Conserved Domains (1) summary
      cl21494
      Location:84396
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106876986..106891350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153835.1XP_036009728.1  phospholipase A2 group XV isoform X1

      Conserved Domains (1) summary
      cl21494
      Location:45357
      Abhydrolase; alpha/beta hydrolases
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