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    Igk immunoglobulin kappa chain complex [ Mus musculus (house mouse) ]

    Gene ID: 243469, updated on 16-Jul-2021

    Summary

    Official Symbol
    Igkprovided by MGI
    Official Full Name
    immunoglobulin kappa chain complexprovided by MGI
    Primary source
    MGI:MGI:96494
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    k; kappa
    Summary
    Summary:Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the kappa light chain locus from the C57BL/6J inbred mouse strain. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments in this cluster are incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Jul 2008]
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    Genomic context

    See Igk in Genome Data Viewer
    Location:
    6 C1; 6 30.89 cM
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (67532620..70703738)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (67555636..70726754)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (67505630..70676748)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene myc induced nuclear antigen pseudogene Neighboring gene immunoglobulin kappa chain variable 2-137 Neighboring gene immunoglobulin kappa chain variable 14-134-1 Neighboring gene immunoglobulin kappa chain variable 1-136 Neighboring gene ribosomal protein L18A, pseudogene 2 Neighboring gene interleukin 23 receptor Neighboring gene immunoglobulin kappa variable 1-135 Neighboring gene tumor-associated calcium signal transducer 2 Neighboring gene immunoglobulin kappa chain variable 17-134 Neighboring gene ribosomal protein L18A, pseudogene 3 Neighboring gene immunoglobulin kappa variable 1-133 Neighboring gene immunoglobulin kappa chain variable 14-126-1 Neighboring gene immunoglobulin kappa variable 14-130 Neighboring gene immunoglobulin kappa variable 1-132 Neighboring gene tubulin, alpha 1A pseudogene Neighboring gene immunoglobulin kappa variable 1-131 Neighboring gene predicted gene, 38573 Neighboring gene immunoglobulin kappa variable 17-127 Neighboring gene immunoglobulin kappa variable 9-129 Neighboring gene immunoglobulin kappa variable 14-126 Neighboring gene immunoglobulin kappa chain variable 9-128 Neighboring gene immunoglobulin kappa variable 11-125 Neighboring gene EGF-like repeats and discoidin I-like domains 3 pseudogene Neighboring gene tubulin, alpha 1A pseudogene Neighboring gene predicted gene, 22425 Neighboring gene predicted gene, 24911 Neighboring gene immunoglobulin kappa chain variable 14-118-2 Neighboring gene immunoglobulin kappa chain variable 14-118-1 Neighboring gene immunoglobulin kappa chain variable 9-124 Neighboring gene immunoglobulin kappa variable 9-123 Neighboring gene immunoglobulin kappa variable 17-121 Neighboring gene predicted gene, 25910 Neighboring gene immunoglobulin kappa chain variable 1-122 Neighboring gene ARP2 actin-related protein 2 homolog pseudogene Neighboring gene immunoglobulin kappa chain variable 9-120 Neighboring gene immunoglobulin kappa chain variable 9-119 Neighboring gene immunoglobulin kappa chain variable 11-118 Neighboring gene immunoglobulin kappa chain variable Neighboring gene immunoglobulin kappa variable 1-117 Neighboring gene immunoglobulin kappa variable 2-116 Neighboring gene immunoglobulin kappa variable 1-115 Neighboring gene immunoglobulin kappa chain variable 2-113 Neighboring gene immunoglobulin kappa variable 14-111 Neighboring gene immunoglobulin kappa variable 2-112 Neighboring gene nucleosome assembly protein 1-like 1 pseudogene Neighboring gene immunoglobulin kappa variable 1-110 Neighboring gene immunoglobulin kappa variable 11-106 Neighboring gene immunoglobulin kappa variable 2-109 Neighboring gene immunoglobulin kappa variable 1-108 Neighboring gene immunoglobulin kappa variable 2-107 Neighboring gene immunoglobulin kappa chain variable 20-101-2 Neighboring gene immunoglobulin kappa chain variable 15-101-1 Neighboring gene predicted gene, 25436 Neighboring gene immunoglobulin kappa chain variable 2-105 Neighboring gene cortactin pseudogene Neighboring gene immunoglobulin kappa variable 16-104 Neighboring gene immunoglobulin kappa chain variable 15-103 Neighboring gene immunoglobulin kappa chain variable 15-102 Neighboring gene immunoglobulin kappa chain variable 15-101 Neighboring gene immunoglobulin kappa chain variable 14-100 Neighboring gene cortactin pseudogene Neighboring gene immunoglobulin kappa variable 12-98 Neighboring gene immunoglobulin kappa variable 1-99 Neighboring gene immunoglobulin kappa chain variable 15-97 Neighboring gene immunoglobulin kappa variable 2-95-2 Neighboring gene predicted gene, 25833 Neighboring gene immunoglobulin kappa chain variable Neighboring gene immunoglobulin kappa variable 10-96 Neighboring gene immunoglobulin kappa chain variable 2-93-1 Neighboring gene immunoglobulin kappa variable 10-95 Neighboring gene immunoglobulin kappa variable 10-94 Neighboring gene immunoglobulin kappa chain variable 13-89-1 Neighboring gene immunoglobulin kappa chain variable 19-93 Neighboring gene immunoglobulin kappa variable 4-92 Neighboring gene immunoglobulin kappa chain variable 4-91 Neighboring gene immunoglobulin kappa chain variable 12-89 Neighboring gene immunoglobulin kappa chain variable 4-90 Neighboring gene immunoglobulin kappa chain variable 1-88 Neighboring gene immunoglobulin kappa variable 13-87 Neighboring gene immunoglobulin kappa chain variable 13-80-1 Neighboring gene immunoglobulin kappa chain variable 13-85 Neighboring gene immunoglobulin kappa chain variable 13-84 Neighboring gene immunoglobulin kappa variable 4-86 Neighboring gene immunoglobulin kappa variable 13-78-1 Neighboring gene predicted gene, 53190 Neighboring gene immunoglobulin kappa chain variable 13-82 Neighboring gene immunoglobulin kappa chain variable 4-83 Neighboring gene immunoglobulin kappa variable 4-81 Neighboring gene immunoglobulin kappa variable 4-80 Neighboring gene immunoglobulin kappa chain variable 13-74-1 Neighboring gene immunoglobulin kappa variable 4-79 Neighboring gene immunoglobulin kappa chain variable 13-73-1 Neighboring gene immunoglobulin kappa variable 4-78 Neighboring gene immunoglobulin kappa chain variable 13-76 Neighboring gene immunoglobulin kappa chain variable 13-71-1 Neighboring gene immunoglobulin kappa variable 4-77 Neighboring gene immunoglobulin kappa chain variable 4-75 Neighboring gene immunoglobulin kappa variable 4-74 Neighboring gene immunoglobulin kappa variable 4-73 Neighboring gene immunoglobulin kappa chain variable 4-72 Neighboring gene immunoglobulin kappa chain variable 4-71 Neighboring gene immunoglobulin kappa chain variable 13-62-1 Neighboring gene immunoglobulin kappa chain variable 13-61-1 Neighboring gene immunoglobulin kappa chain variable 4-70 Neighboring gene immunoglobulin kappa variable 4-69 Neighboring gene immunoglobulin kappa chain variable 12-67 Neighboring gene immunoglobulin kappa chain variable 12-66 Neighboring gene immunoglobulin kappa variable 4-68 Neighboring gene immunoglobulin kappa chain variable 13-64 Neighboring gene immunoglobulin kappa chain variable 4-65 Neighboring gene immunoglobulin kappa variable 4-63 Neighboring gene immunoglobulin kappa variable 13-57-2 Neighboring gene immunoglobulin kappa variable 4-62 Neighboring gene immunoglobulin kappa chain variable 4-61 Neighboring gene immunoglobulin kappa chain variable 13-57-1 Neighboring gene immunoglobulin kappa variable 4-59 Neighboring gene immunoglobulin kappa chain variable 13-56-1 Neighboring gene immunoglobulin kappa variable 4-57-1 Neighboring gene immunoglobulin kappa variable 4-60 Neighboring gene immunoglobulin kappa chain variable 13-55-1 Neighboring gene ribonuclease P RNA-like 1 Neighboring gene immunoglobulin kappa chain variable 13-54-1 Neighboring gene immunoglobulin kappa variable 4-58 Neighboring gene immunoglobulin kappa variable 4-57 Neighboring gene immunoglobulin kappa chain variable 4-56 Neighboring gene immunoglobulin kappa variable 4-55 Neighboring gene immunoglobulin kappa chain variable 4-54 Neighboring gene immunoglobulin kappa variable 4-53 Neighboring gene immunoglobulin kappa chain variable 12-49 Neighboring gene immunoglobulin kappa chain variable 4-51 Neighboring gene immunoglobulin kappa variable 12-47 Neighboring gene immunoglobulin kappa variable 4-50 Neighboring gene immunoglobulin kappa variable 5-48 Neighboring gene immunoglobulin kappa variable 12-46 Neighboring gene immunoglobulin kappa variable 12-44 Neighboring gene immunoglobulin kappa chain variable 5-45 Neighboring gene immunoglobulin kappa chain variable 5-40-1 Neighboring gene immunoglobulin kappa chain variable 12-42 Neighboring gene immunoglobulin kappa chain variable 12-41 Neighboring gene immunoglobulin kappa chain variable 5-43 Neighboring gene immunoglobulin kappa chain variable 12-40 Neighboring gene immunoglobulin kappa variable 5-39 Neighboring gene immunoglobulin kappa chain variable 12-38 Neighboring gene immunoglobulin kappa chain variable 18-36 Neighboring gene immunoglobulin kappa variable 5-37 Neighboring gene immunoglobulin kappa variable 1-35 Neighboring gene immunoglobulin kappa variable 8-34 Neighboring gene immunoglobulin kappa chain variable 7-33 Neighboring gene immunoglobulin kappa variable 6-32 Neighboring gene immunoglobulin kappa chain variable 8-31 Neighboring gene immunoglobulin kappa chain variable 8-30 Neighboring gene immunoglobulin kappa chain variable 6-29 Neighboring gene immunoglobulin kappa variable 8-28 Neighboring gene immunoglobulin kappa variable 8-23-1 Neighboring gene immunoglobulin kappa chain variable 8-27 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 2 Neighboring gene immunoglobulin kappa variable 8-26 Neighboring gene immunoglobulin kappa chain variable 6-25 Neighboring gene immunoglobulin kappa chain variable 8-24 Neighboring gene immunoglobulin kappa variable 6-23 Neighboring gene predicted gene, 46962 Neighboring gene immunoglobulin kappa chain variable 8-22 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene immunoglobulin kappa variable 8-21 Neighboring gene immunoglobulin kappa variable 6-20 Neighboring gene immunoglobulin kappa variable 8-19 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene immunoglobulin kappa variable 8-18 Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 5 Neighboring gene immunoglobulin kappa variable 6-17 Neighboring gene immunoglobulin kappa variable 8-16 Neighboring gene immunoglobulin kappa chain variable 3-12-1 Neighboring gene immunoglobulin kappa variable 6-15 Neighboring gene immunoglobulin kappa variable 6-14 Neighboring gene immunoglobulin kappa variable 6-13 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene immunoglobulin kappa variable 3-12 Neighboring gene solute carrier family 5 (sodium-dependent vitamin transporter), member 6 pseudogene Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene immunoglobulin kappa variable 3-11 Neighboring gene immunoglobulin kappa variable 3-10 Neighboring gene immunoglobulin kappa variable 3-9 Neighboring gene immunoglobulin kappa variable 3-8 Neighboring gene immunoglobulin kappa variable 3-7 Neighboring gene immunoglobulin kappa variable 3-6 Neighboring gene immunoglobulin kappa chain variable 3-5 Neighboring gene immunoglobulin kappa variable 3-4 Neighboring gene immunoglobulin kappa variable 3-3 Neighboring gene immunoglobulin kappa variable 3-2 Neighboring gene immunoglobulin kappa variable 3-1 Neighboring gene predicted gene, 46961 Neighboring gene predicted gene, 30211 Neighboring gene immunoglobulin kappa joining 1 Neighboring gene immunoglobulin kappa joining 2 Neighboring gene immunoglobulin kappa joining 3 Neighboring gene immunoglobulin kappa joining 4 Neighboring gene immunoglobulin kappa joining 5 Neighboring gene immunoglobulin kappa constant Neighboring gene ribose 5-phosphate isomerase A

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Other Names

    • kappa light chain variable region

    Clone Names

    • MGC6612, MGC28604, MGC41421, MGC102615, MGC150007

    General protein information

    Names
    immunoglobulin kappa chain complex
    kappa light chain variable region

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_005612.1 

      Range
      656..3171774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      67532620..70703738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013763.1: Suppressed sequence

      Description
      NM_001013763.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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