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    Cars cysteinyl-tRNA synthetase [ Mus musculus (house mouse) ]

    Gene ID: 27267, updated on 23-Jun-2021

    Summary

    Official Symbol
    Carsprovided by MGI
    Official Full Name
    cysteinyl-tRNA synthetaseprovided by MGI
    Primary source
    MGI:MGI:1351477
    See related
    Ensembl:ENSMUSG00000010755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CA; CA3; Cars1
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.8), liver E14 (RPKM 11.5) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cars in Genome Data Viewer
    Location:
    7 F5; 7 88.25 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143110967..143153827, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143557230..143600090, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (150743610..150785947, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology like domain, family A, member 2 Neighboring gene nucleosome assembly protein 1-like 4 Neighboring gene predicted gene, 23297 Neighboring gene microRNA 7064 Neighboring gene predicted gene 15580 Neighboring gene predicted gene 15579 Neighboring gene tumor necrosis factor receptor superfamily, member 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cysteine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cysteinyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cysteinyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cysteine--tRNA ligase, cytoplasmic
    Names
    cysRS
    cysteinyl-tRNA synthetase, cytoplasmic
    NP_001239522.1
    NP_038770.3
    XP_006508690.1
    XP_011240303.1
    XP_017177784.1
    XP_030098491.1
    XP_036009038.1
    XP_036009039.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252593.1NP_001239522.1  cysteine--tRNA ligase, cytoplasmic isoform 2

      See identical proteins and their annotated locations for NP_001239522.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame, exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK152866, BC030473, BY021374, BY253195
      Consensus CDS
      CCDS57597.1
      UniProtKB/Swiss-Prot
      Q9ER72
      UniProtKB/TrEMBL
      Q3U716
      Related
      ENSMUSP00000101529.4, ENSMUST00000105909.4
      Conserved Domains (2) summary
      cd00672
      Location:30445
      CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
      PTZ00399
      Location:1739
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional
    2. NM_013742.5NP_038770.3  cysteine--tRNA ligase, cytoplasmic isoform 1

      See identical proteins and their annotated locations for NP_038770.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AJ276796, AK135433, BC030473, BY021374, BY253195
      Consensus CDS
      CCDS40198.1
      UniProtKB/Swiss-Prot
      Q9ER72
      UniProtKB/TrEMBL
      Q3UXN3
      Related
      ENSMUSP00000010899.8, ENSMUST00000010899.14
      Conserved Domains (3) summary
      cd00672
      Location:113528
      CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
      cd10310
      Location:476
      GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
      PTZ00399
      Location:91827
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      143110967..143153827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153145.1XP_036009038.1  cysteine--tRNA ligase, cytoplasmic isoform X2

      Conserved Domains (2) summary
      cd10310
      Location:476
      GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
      PTZ00399
      Location:91720
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional
    2. XM_011242001.2XP_011240303.1  cysteine--tRNA ligase, cytoplasmic isoform X4

      See identical proteins and their annotated locations for XP_011240303.1

      Conserved Domains (1) summary
      PTZ00399
      Location:118647
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional
    3. XM_006508627.3XP_006508690.1  cysteine--tRNA ligase, cytoplasmic isoform X1

      Conserved Domains (2) summary
      cd10310
      Location:476
      GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
      PTZ00399
      Location:91807
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional
    4. XM_030242631.1XP_030098491.1  cysteine--tRNA ligase, cytoplasmic isoform X4

      Conserved Domains (1) summary
      PTZ00399
      Location:118647
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional
    5. XM_036153146.1XP_036009039.1  cysteine--tRNA ligase, cytoplasmic isoform X5

      Conserved Domains (1) summary
      PTZ00399
      Location:45522
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional
    6. XM_017322295.1XP_017177784.1  cysteine--tRNA ligase, cytoplasmic isoform X3

      Conserved Domains (2) summary
      cd10310
      Location:476
      GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
      PTZ00399
      Location:91690
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional

    RNA

    1. XR_378611.2 RNA Sequence

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