Igkv1-117 immunoglobulin kappa variable 1-117 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Igkv1-117provided by MGI
Official Full Name: immunoglobulin kappa variable 1-117provided by MGI
Primary source: MGI:MGI:4439721
See related: Ensembl:ENSMUSG00000094335 IMGT/GENE-DB:IGKV1-117; AllianceGenome:MGI:4439721
Gene type: other
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cr1; IgK; Gm16797; Igk-V21; V(k)45.1
Summary: Predicted to be involved in immune response. Predicted to be active in extracellular space. Orthologous to human IGKV2-28 (immunoglobulin kappa variable 2-28) and IGKV2D-28 (immunoglobulin kappa variable 2D-28). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 6 C1; 6 31.07 cM

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (68098075..68098809)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (68121091..68121825)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

After induction of mixed chimerism from alphaGal+ allogeneic bone marrow (BM) donors, anti-alphaGal-producing B cells were rendered tolerant in reconstituted recipients expressing only stromal CR1/CR2.
Title: B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-alphaGAL-producing B-1 cells.
IgM binding to ischemic tissues precedes damaging complement activation by significant period of time. Implications for anti-inflammatory therapy for reperfusion injury.
Title: IgM binding to injured tissue precedes complement activation during skeletal muscle ischemia-reperfusion.
IgM knockout mice show an increase in severity of West Nile virus infection.
Title: Early induced IgM as a predictor and risk factor for severe disease outcome after West Nile virus infection.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127636 (e-PCR)
- UniSTS:210946

NoName (e-PCR)
- UniSTS:489614

Igk-C (e-PCR), detects polymorphism
- UniSTS:143506

Igk-V1 (e-PCR), detects polymorphism
- UniSTS:143508

AV061724 (e-PCR)
- UniSTS:179389

Other Names

Ig kappa chain
anti-phenyloxazolone mAb L chain
anti-poly(dC) monoclonal antibody kappa light chain
immunoglobulin kappa chain variable 1-117
immunoglobulin kappa chain variable 21 (V21)
polyreactive autoantibody, immunoglobulin light chain kappa

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immunoglobulin production	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.