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    Fgfr4 fibroblast growth factor receptor 4 [ Mus musculus (house mouse) ]

    Gene ID: 14186, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fgfr4provided by MGI
    Official Full Name
    fibroblast growth factor receptor 4provided by MGI
    Primary source
    MGI:MGI:95525
    See related
    Ensembl:ENSMUSG00000005320
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fgfr-; Fgfr-4
    Expression
    Biased expression in adrenal adult (RPKM 26.0), lung adult (RPKM 20.3) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fgfr4 in Genome Data Viewer
    Location:
    13 B1; 13 29.8 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55300631..55316572)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55152818..55168759)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55254179..55270120)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene zinc finger protein 346 Neighboring gene predicted gene, 46415 Neighboring gene nuclear receptor-binding SET-domain protein 1 Neighboring gene RAB24, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fibroblast growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fibroblast growth factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fibroblast growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within alveolar secondary septum development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of fibroblast growth factor production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within organ induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphate ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of parathyroid hormone secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of bile acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of bile acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of phosphate transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of phosphorus metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within vitamin D3 metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor receptor 4
    Names
    CTLA-2-beta protein
    fibroblast growth factor receptor 4 16 minus form
    protein-tyrosine kinase receptor MPK-11
    NP_032037.2
    XP_006517162.3
    XP_006517163.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008011.2NP_032037.2  fibroblast growth factor receptor 4 precursor

      See identical proteins and their annotated locations for NP_032037.2

      Status: VALIDATED

      Source sequence(s)
      AK084850
      Consensus CDS
      CCDS26540.1
      UniProtKB/Swiss-Prot
      Q03142
      UniProtKB/TrEMBL
      A0A0R4IZY3
      Related
      ENSMUSP00000005452.6, ENSMUST00000005452.6
      Conserved Domains (6) summary
      cd05099
      Location:451764
      PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4
      cd05858
      Location:261348
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:47104
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:159238
      IG_like; Immunoglobulin like
      pfam07714
      Location:464740
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:154238
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      55300631..55316572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517099.3XP_006517162.3  fibroblast growth factor receptor 4 isoform X1

      Conserved Domains (4) summary
      cd05099
      Location:481794
      PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4
      cd05858
      Location:291378
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:77134
      IGc2; Immunoglobulin C-2 Type
      cl11960
      Location:184268
      Ig; Immunoglobulin domain
    2. XM_006517100.2XP_006517163.1  fibroblast growth factor receptor 4 isoform X2

      Conserved Domains (2) summary
      cd05099
      Location:205518
      PTKc_FGFR4; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4
      cd05858
      Location:15102
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
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