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    Hip1 huntingtin interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 215114, updated on 23-Jun-2021

    Summary

    Official Symbol
    Hip1provided by MGI
    Official Full Name
    huntingtin interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1099804
    See related
    Ensembl:ENSMUSG00000039959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HIP; mKIAA4113; 2610109B09Rik; A930014B11Rik; E130315I21Rik
    Expression
    Ubiquitous expression in lung adult (RPKM 13.0), subcutaneous fat pad adult (RPKM 12.6) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Hip1 in Genome Data Viewer
    Location:
    5 G2; 5 75.18 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135435350..135574167, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135406496..135545323, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (135882388..136020992, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene NOL1/NOP2/Sun domain family, member 5 Neighboring gene nuclear pore membrane protein 121 Neighboring gene microRNA 7033 Neighboring gene predicted gene, 52790 Neighboring gene chemokine (C-C motif) ligand 26 Neighboring gene chemokine (C-C motif) ligand 24

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (8)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4113, MGC27616

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables AP-2 adaptor complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables clathrin light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables clathrin light chain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,4-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in clathrin coat assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in actin cortical patch IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extrinsic component of postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extrinsic component of postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    huntingtin-interacting protein 1
    Names
    HIP-I
    huntingtin-interacting protein I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382848.1NP_001369777.1  huntingtin-interacting protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC024608
      Conserved Domains (4) summary
      smart00307
      Location:772970
      ILWEQ; I/LWEQ domain
      COG1196
      Location:363602
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07651
      Location:7272
      ANTH; ANTH domain
      pfam16515
      Location:454538
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    2. NM_146001.2NP_666113.2  huntingtin-interacting protein 1 isoform 1

      See identical proteins and their annotated locations for NP_666113.2

      Status: VALIDATED

      Source sequence(s)
      AK147246, BC017516, BY309818, CF746398
      Consensus CDS
      CCDS51663.1
      UniProtKB/Swiss-Prot
      Q8VD75
      Related
      ENSMUSP00000059033.9, ENSMUST00000060311.12
      Conserved Domains (5) summary
      smart00307
      Location:8061004
      ILWEQ; I/LWEQ domain
      COG1196
      Location:397636
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07651
      Location:42307
      ANTH; ANTH domain
      pfam16515
      Location:482572
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
      pfam14335
      Location:336441
      DUF4391; Domain of unknown function (DUF4391)

    RNA

    1. NR_168637.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC024608

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      135435350..135574167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240878.4XP_011239180.1  huntingtin-interacting protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011239180.1

      UniProtKB/Swiss-Prot
      Q8VD75
      Conserved Domains (5) summary
      smart00307
      Location:8061004
      ILWEQ; I/LWEQ domain
      COG1196
      Location:397636
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07651
      Location:42307
      ANTH; ANTH domain
      pfam16515
      Location:482572
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
      pfam14335
      Location:336441
      DUF4391; Domain of unknown function (DUF4391)
    2. XM_036164986.1XP_036020879.1  huntingtin-interacting protein 1 isoform X1

      Conserved Domains (4) summary
      smart00307
      Location:8141012
      ILWEQ; I/LWEQ domain
      COG1196
      Location:389644
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07651
      Location:39306
      ANTH; ANTH domain
      pfam16515
      Location:488580
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    3. XM_036164985.1XP_036020878.1  huntingtin-interacting protein 1 isoform X1

      Conserved Domains (4) summary
      smart00307
      Location:8141012
      ILWEQ; I/LWEQ domain
      COG1196
      Location:389644
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07651
      Location:39306
      ANTH; ANTH domain
      pfam16515
      Location:488580
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    4. XM_036164989.1XP_036020882.1  huntingtin-interacting protein 1 isoform X4

      Conserved Domains (4) summary
      smart00307
      Location:780978
      ILWEQ; I/LWEQ domain
      COG1196
      Location:355610
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07651
      Location:7272
      ANTH; ANTH domain
      pfam16515
      Location:454546
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    5. XM_036164990.1XP_036020883.1  huntingtin-interacting protein 1 isoform X5

      Conserved Domains (4) summary
      smart00307
      Location:772970
      ILWEQ; I/LWEQ domain
      COG1196
      Location:363602
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07651
      Location:7272
      ANTH; ANTH domain
      pfam16515
      Location:454538
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    6. XM_036164987.1XP_036020880.1  huntingtin-interacting protein 1 isoform X3

      Conserved Domains (4) summary
      smart00307
      Location:789987
      ILWEQ; I/LWEQ domain
      COG1196
      Location:364619
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07651
      Location:15281
      ANTH; ANTH domain
      pfam16515
      Location:463555
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    7. XM_036164988.1XP_036020881.1  huntingtin-interacting protein 1 isoform X3

      Conserved Domains (4) summary
      smart00307
      Location:789987
      ILWEQ; I/LWEQ domain
      COG1196
      Location:364619
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07651
      Location:15281
      ANTH; ANTH domain
      pfam16515
      Location:463555
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1

    RNA

    1. XR_004942493.1 RNA Sequence

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