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    Dclk1 doublecortin-like kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 13175, updated on 14-Sep-2021

    Summary

    Official Symbol
    Dclk1provided by MGI
    Official Full Name
    doublecortin-like kinase 1provided by MGI
    Primary source
    MGI:MGI:1330861
    See related
    Ensembl:ENSMUSG00000027797
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dc; Dcl; CPG1; Clic; Dclk; Cpg16; Dcamk; Click-I; Dcamkl1; AI836758; mKIAA0369; 1700113D08Rik; 2810480F11Rik
    Summary
    This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been found, but the biological validity of some variants has not been determined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. [provided by RefSeq, Sep 2010]
    Expression
    Biased expression in frontal lobe adult (RPKM 35.3), cortex adult (RPKM 34.0) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Dclk1 in Genome Data Viewer
    Location:
    3; 3 C
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (55149724..55446489)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (55242303..55539068)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (55046448..55342990)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 169 Neighboring gene spermatogenesis and oogenesis specific basic helix-loop-helix 2 Neighboring gene predicted gene, 25132 Neighboring gene predicted gene 9831 Neighboring gene predicted gene, 31443 Neighboring gene U6 spliceosomal RNA Neighboring gene predicted gene, 31796 Neighboring gene predicted gene, 25404

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within brain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within central nervous system projection neuron axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within dendrite morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase DCLK1
    Names
    CLICK-I beta
    doublecortin and calcium/calmodulin-dependent protein kinase-like 1
    doublecortin-like and CAM kinase-like 1
    NP_001104521.1
    NP_001104522.1
    NP_001104523.1
    NP_001182467.1
    NP_001182468.1
    NP_001182469.1
    NP_001344395.1
    NP_001344397.1
    NP_001344398.1
    NP_001344404.1
    NP_001344405.1
    NP_064362.1
    XP_006501044.1
    XP_006501045.1
    XP_006501046.1
    XP_017174936.1
    XP_030108271.1
    XP_030108272.1
    XP_036018774.1
    XP_036018775.1
    XP_036018776.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111051.2NP_001104521.1  serine/threonine-protein kinase DCLK1 isoform 2

      See identical proteins and their annotated locations for NP_001104521.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as DCLK-short-A, DCK-beta2, KIAA0369-BL or cpg16 (candidate plasticity gene 16)] is produced from the 3' promoter. It lacks several 5' exons but has an alternate 5' exon, as compared to variant 5. The resulting isoform (2) has a shorter and different N-terminus, and lacks doublecortin domains, as compared to isoform 5.
      Source sequence(s)
      AC115945, AF155821, BF467198, BY123015
      UniProtKB/TrEMBL
      Q9JLM6
      Related
      ENSMUSP00000142637.2, ENSMUST00000198412.5
      Conserved Domains (2) summary
      smart00220
      Location:83340
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14183
      Location:76343
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    2. NM_001111052.2NP_001104522.1  serine/threonine-protein kinase DCLK1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as DCLK-short-B, DCK-beta1 or KIAA0369-BS ) is produced from the 3' promoter. It lacks several 5' exons but has an alternate 5' exon, and has an additional exon in the 3' CDS that results in a frameshift, as compared to variant 5. The resulting isoform (3) has shorter and different N- and C-termini, and lacks doublecortin domains, as compared to isoform 5.
      Source sequence(s)
      AC115945, BF467198
      Consensus CDS
      CCDS50910.1
      UniProtKB/TrEMBL
      H7BX36
      Related
      ENSMUSP00000070292.5, ENSMUST00000070418.9
      Conserved Domains (2) summary
      smart00220
      Location:83340
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14183
      Location:76343
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    3. NM_001111053.2NP_001104523.1  serine/threonine-protein kinase DCLK1 isoform 4

      See identical proteins and their annotated locations for NP_001104523.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as DCL (PMID: 17313568)) is produced from the 5' promoter. It lacks several 3' exons but has an alternate 3' exon, as compared to variant 5. The resulting isoform (4) has a shorter and distinct C-terminus, and lacks a serine/proline-rich domain and a protein kinase domain, as compared to isoform 5.
      Source sequence(s)
      AC111132, AC115945, AK147831, BC050903, CJ241697
      Consensus CDS
      CCDS50909.1
      UniProtKB/TrEMBL
      Q80VB6
      Related
      ENSMUSP00000129334.2, ENSMUST00000167204.8
      Conserved Domains (2) summary
      cd17069
      Location:182265
      DCX2; Dublecortin-like domain 2
      cd17140
      Location:55143
      DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
    4. NM_001195538.2NP_001182467.1  serine/threonine-protein kinase DCLK1 isoform 5

      See identical proteins and their annotated locations for NP_001182467.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as DCLK-long-A, DCK-alpha2, KIAA0369-AL, DCAMKL1 or zyg8) is produced from the 5' promoter. It encodes isoform 5, which includes two doublecortin domains, a serine/proline-rich domain and a protein kinase domain.
      Source sequence(s)
      AC104099, AC111132, AC115945, BF467198
      UniProtKB/TrEMBL
      A3KN70
      Conserved Domains (3) summary
      smart00220
      Location:390647
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:52142
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14183
      Location:383650
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    5. NM_001195539.2NP_001182468.1  serine/threonine-protein kinase DCLK1 isoform 6

      See identical proteins and their annotated locations for NP_001182468.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6, also known as DCLK-short-C or DCK-beta2-R) is produced from the 3' promoter. It lacks several 5' exons but has an alternate 5' exon, and has an additional in-frame segment in the CDS, as compared to variant 5. The resulting isoform (6) has a shorter and different N-terminus, and lacks doublecortin domains but has an additional Arg-rich segment, as compared to isoform 5.
      Source sequence(s)
      AC115945, AF155821, AK032424, BF467198, BY123015
      Consensus CDS
      CCDS79909.1
      UniProtKB/TrEMBL
      Q8CCN4
      Related
      ENSMUSP00000143016.2, ENSMUST00000198437.5
      Conserved Domains (2) summary
      smart00220
      Location:99356
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14183
      Location:92359
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    6. NM_001195540.2NP_001182469.1  serine/threonine-protein kinase DCLK1 isoform 7

      See identical proteins and their annotated locations for NP_001182469.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) is produced from the 3' promoter. It shares only one exon with variant 5, and encodes a 56 aa isoform [7, also known as ania-4, or CARP (CaMK-related peptide)], which mainly consists of the serine/proline-rich domain.
      Source sequence(s)
      AC115945, BY126617
      Consensus CDS
      CCDS79908.1
      UniProtKB/TrEMBL
      A8IP62
      Related
      ENSMUSP00000142698.2, ENSMUST00000199585.5
    7. NM_001357466.1NP_001344395.1  serine/threonine-protein kinase DCLK1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC104099, AC111132, AC115945, BF467198
      Conserved Domains (2) summary
      smart00537
      Location:52142
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14183
      Location:383650
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    8. NM_001357468.1NP_001344397.1  serine/threonine-protein kinase DCLK1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC115945, BF467198
      Conserved Domains (1) summary
      cd14183
      Location:92359
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    9. NM_001357469.1NP_001344398.1  serine/threonine-protein kinase DCLK1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC104099, AC111132, AC115945, BF467198
      Conserved Domains (2) summary
      smart00537
      Location:52142
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14183
      Location:399666
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    10. NM_001357475.1NP_001344404.1  serine/threonine-protein kinase DCLK1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC104099, AC111132, AC115945, BF467198
      Consensus CDS
      CCDS89626.1
      Related
      ENSMUSP00000143659.2, ENSMUST00000196745.5
      Conserved Domains (2) summary
      smart00537
      Location:52142
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14183
      Location:383649
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    11. NM_001357476.1NP_001344405.1  serine/threonine-protein kinase DCLK1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC115945, BF467198
      Consensus CDS
      CCDS89627.1
      Related
      ENSMUSP00000143507.2, ENSMUST00000199702.5
      Conserved Domains (1) summary
      cd14183
      Location:75342
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    12. NM_019978.4NP_064362.1  serine/threonine-protein kinase DCLK1 isoform 1

      See identical proteins and their annotated locations for NP_064362.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as DCLK-long-C, DCK-alpha2-R) is produced from the 5' promoter. It has an additional in-frame segment in the CDS, as compared to variant 5. The resulting isoform (1) is the longest isoform which includes an Arg-rich domain, in addition to two doublecortin domains, a serine/proline-rich domain and a protein kinase domain, as compared to isoform 5.
      Source sequence(s)
      AC111132, AC115945, AF155819, BF467198
      Consensus CDS
      CCDS17359.1
      UniProtKB/Swiss-Prot
      Q9JLM8
      Related
      ENSMUSP00000050034.8, ENSMUST00000054237.14
      Conserved Domains (3) summary
      smart00220
      Location:406663
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:52142
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14183
      Location:399666
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      55149724..55446489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319447.3XP_017174936.1  serine/threonine-protein kinase DCLK1 isoform X1

      Conserved Domains (3) summary
      cd14183
      Location:399666
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
      cd17069
      Location:182265
      DCX2; Dublecortin-like domain 2
      cd17140
      Location:55143
      DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
    2. XM_036162883.1XP_036018776.1  serine/threonine-protein kinase DCLK1 isoform X8

      Conserved Domains (2) summary
      cd17069
      Location:182265
      DCX2; Dublecortin-like domain 2
      cd17140
      Location:55143
      DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
    3. XM_006500983.5XP_006501046.1  serine/threonine-protein kinase DCLK1 isoform X8

      See identical proteins and their annotated locations for XP_006501046.1

      UniProtKB/TrEMBL
      Q80VB6
      Conserved Domains (2) summary
      cd17069
      Location:182265
      DCX2; Dublecortin-like domain 2
      cd17140
      Location:55143
      DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
    4. XM_006500982.3XP_006501045.1  serine/threonine-protein kinase DCLK1 isoform X7

      See identical proteins and their annotated locations for XP_006501045.1

      UniProtKB/TrEMBL
      Q8BRN4
      Conserved Domains (2) summary
      cd17069
      Location:182265
      DCX2; Dublecortin-like domain 2
      cd17140
      Location:55143
      DCX1_DCLK1; Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1)
    5. XM_030252412.2XP_030108272.1  serine/threonine-protein kinase DCLK1 isoform X6

      Conserved Domains (1) summary
      cd14183
      Location:42309
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    6. XM_006500981.5XP_006501044.1  serine/threonine-protein kinase DCLK1 isoform X2

      See identical proteins and their annotated locations for XP_006501044.1

      Conserved Domains (1) summary
      cd14183
      Location:58325
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    7. XM_030252411.2XP_030108271.1  serine/threonine-protein kinase DCLK1 isoform X4

      Conserved Domains (1) summary
      cd14183
      Location:42309
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    8. XM_036162882.1XP_036018775.1  serine/threonine-protein kinase DCLK1 isoform X5

      Conserved Domains (1) summary
      cd14183
      Location:41308
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)
    9. XM_036162881.1XP_036018774.1  serine/threonine-protein kinase DCLK1 isoform X3

      Conserved Domains (1) summary
      cd14183
      Location:57324
      STKc_DCKL1; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1)

    RNA

    1. XR_004941275.1 RNA Sequence

    2. XR_004941274.1 RNA Sequence

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