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    Rsad2 radical S-adenosyl methionine domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 58185, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rsad2provided by MGI
    Official Full Name
    radical S-adenosyl methionine domain containing 2provided by MGI
    Primary source
    MGI:MGI:1929628
    See related
    Ensembl:ENSMUSG00000020641
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    v; Vi; cig; Vig1; cig5; 2510004L01Rik
    Expression
    Biased expression in liver E18 (RPKM 29.0), spleen adult (RPKM 9.1) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rsad2 in Genome Data Viewer
    Location:
    12; 12 A2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (26492742..26506451, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (26442743..26456452, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (27127608..27141317, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 144A Neighboring gene RIKEN cDNA 4930549C15 gene Neighboring gene microRNA 6538 Neighboring gene cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial Neighboring gene predicted gene, 46344

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein self-association ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in CD4-positive, alpha-beta T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in CD4-positive, alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T-helper 2 cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of toll-like receptor 7 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of toll-like receptor 9 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    radical S-adenosyl methionine domain-containing protein 2
    Names
    VHSV-induced-like protein
    viperin
    viral hemorrhagic septicemia virus (VHSV)-induced gene 1
    virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021384.4NP_067359.2  radical S-adenosyl methionine domain-containing protein 2

      See identical proteins and their annotated locations for NP_067359.2

      Status: VALIDATED

      Source sequence(s)
      AK151476, AK153234, CK623585
      Consensus CDS
      CCDS25848.1
      UniProtKB/Swiss-Prot
      Q8CBB9
      Related
      ENSMUSP00000020970.8, ENSMUST00000020970.10
      Conserved Domains (2) summary
      cd01335
      Location:79283
      Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
      TIGR04278
      Location:13362
      viperin; antiviral radical SAM protein viperin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      26492742..26506451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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