Nfkbid nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nfkbidprovided by MGI
Official Full Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, deltaprovided by MGI
Primary source: MGI:MGI:3041243
See related: Ensembl:ENSMUSG00000036931 AllianceGenome:MGI:3041243
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IkappaBNS; ikB-delta; I-kappa-B-delta
Summary: Enables NF-kappaB binding activity. Involved in T cell receptor signaling pathway and positive regulation of T-helper 17 cell differentiation. Acts upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; negative regulation of T cell differentiation in thymus; and positive regulation of thymocyte apoptotic process. Located in nucleus. Orthologous to human NFKBID (NFKB inhibitor delta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 15.9), thymus adult (RPKM 12.6) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 17.52 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30121156..30128173)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30421731..30428749)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic mapping reveals Nfkbid as a central regulator of humoral immunity to Toxoplasma gondii.
Title: Genetic mapping reveals Nfkbid as a central regulator of humoral immunity to Toxoplasma gondii.
IkappaBNS-deficient B cells, in contrast to wt B cells, displayed altered expression of IRF4, Blimp-1 and Pax5 upon LPS-induced differentiation, indicating impaired transcriptional regulation of plasma cell generation.
Title: TACI expression and plasma cell differentiation are impaired in the absence of functional IκBNS.
these results indicated that allelic variants of Nfkbid contribute to the efficiency of intrathymic deletion of diabetogenic CD8+ T cells
Title: A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8(+) T Cells in NOD Mice.
IkappaBNS is involved in inducing Muc5ac expression in lung epithelial cells and causing AHR in HDM-induced asthma models.
Title: IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models.
Deficiency of IkBNS induces atherogenesis in LDL receptor-deficient mice.
Title: Lack of IκBNS accelerates atherosclerosis in LDL receptor-deficient mice via increased interleukin-6 production.
Low expression of IL-6 and TNF-alpha correlates with the presence of the nuclear regulators of NF-kappaB, IkappaBNS and BCL-3, in the uterus of mice.
Title: Low expression of IL-6 and TNF-α correlates with the presence of the nuclear regulators of NF-κB, IκBNS and BCL-3, in the uterus of mice.
investigated the point in the development of B-1 cells where IkappaBNS is required
Title: B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS.
The unique ability of p100/IkappaBdelta to stably interact with all NF-kappaB subunits by forming kappaBsomes demonstrates its importance in sequestering NF-kappaB subunits and releasing them as dictated by specific stimuli for developmental programs.
Title: p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation.
IkappaBNS is a short-lived protein of which the stability is controlled by proteasome, independent of the ubiquitylation process. The N-terminal PEST sequence in IkappaBNS was critical for the regulation of stability.
Title: Regulation of mIκBNS stability through PEST-mediated degradation by proteasome.
A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.
Title: A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NF-kappaB binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of T cell differentiation in thymus	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of T cell differentiation in thymus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T-helper 17 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of thymocyte apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of thymocyte apoptotic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NF-kappa-B inhibitor delta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360906.1 → NP_001347835.1 NF-kappa-B inhibitor delta

Status: VALIDATED

Source sequence(s)

AC149067

Consensus CDS

CCDS21091.1

UniProtKB/Swiss-Prot

Q2TB02, Q3TJP0, Q8CIW1

Conserved Domains (3) summary

PHA03095
Location:60 → 301

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:62 → 96

ANK; ANK repeat [structural motif]

pfam12796
Location:200 → 292

Ank_2; Ankyrin repeats (3 copies)
NM_001360907.1 → NP_001347836.1 NF-kappa-B inhibitor delta

Status: VALIDATED

Source sequence(s)

AC149067, AK167356

Consensus CDS

CCDS21091.1

UniProtKB/Swiss-Prot

Q2TB02, Q3TJP0, Q8CIW1

Related

ENSMUSP00000103810.2, ENSMUST00000108175.8

Conserved Domains (3) summary

PHA03095
Location:60 → 301

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:62 → 96

ANK; ANK repeat [structural motif]

pfam12796
Location:200 → 292

Ank_2; Ankyrin repeats (3 copies)
NM_001421512.1 → NP_001408441.1 NF-kappa-B inhibitor delta

Status: VALIDATED

Source sequence(s)

AC149067

UniProtKB/Swiss-Prot

Q2TB02, Q3TJP0, Q8CIW1
NM_172142.5 → NP_742154.1 NF-kappa-B inhibitor delta

See identical proteins and their annotated locations for NP_742154.1

Status: VALIDATED

Source sequence(s)

AC149067

Consensus CDS

CCDS21091.1

UniProtKB/Swiss-Prot

Q2TB02, Q3TJP0, Q8CIW1

Related

ENSMUSP00000042317.9, ENSMUST00000046177.9

Conserved Domains (3) summary

PHA03095
Location:60 → 301

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:62 → 96

ANK; ANK repeat [structural motif]

pfam12796
Location:200 → 292

Ank_2; Ankyrin repeats (3 copies)