Ildr2 immunoglobulin-like domain containing receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ildr2provided by MGI
Official Full Name: immunoglobulin-like domain containing receptor 2provided by MGI
Primary source: MGI:MGI:1196370
See related: Ensembl:ENSMUSG00000040612 AllianceGenome:MGI:1196370
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ll; Dbsm1; D1Ertd471e; 2810478N18Rik; 3110063L10Rik
Summary: Acts upstream of or within several processes, including homeostasis of number of cells within a tissue; insulin secretion; and response to glucose. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in embryo and retina. Orthologous to human ILDR2 (immunoglobulin like domain containing receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 9.1), cortex adult (RPKM 6.7) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.3; 1 73.61 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (166081630..166144405)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (166254060..166316832)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2).
Title: Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2).
ILDR2 as a novel negative regulator for T cells.
Title: ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.
The potential of ILDR-Fc to provide a promising therapeutic approach for the treatment of autoimmune diseases.
Title: ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance.
We conclude that ILDR2 plays a negligible role in hepatic steatosis. Rather, hepatic steatosis observed previously in Ildr2 knockdown mice was likely due to shRNA targeting of Dgka and/or other "off-target" genes.
Title: ILDR2 has a negligible role in hepatic steatosis.
manipulation of Ildr2 expression in liver affects both lipid homeostasis and ER stress pathways.
Title: ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Targeted (1) 1 citation
QTL (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234261

AI852300 (e-PCR)
- UniSTS:164137

C86954 (e-PCR)
- UniSTS:167275

G49232 (e-PCR)
- UniSTS:108988

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in pancreas development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to glucose	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in tight junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: immunoglobulin-like domain-containing receptor 2

Names: angulin-3; lisch-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164528.1 → NP_001158000.1 immunoglobulin-like domain-containing receptor 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_001158000.1

Status: VALIDATED

Source sequence(s)

AC034122

Consensus CDS

CCDS48431.1

UniProtKB/Swiss-Prot

B5TVM2, B5TVM3, B5TVM4, B5TVM5, B5TVM6, B5TVM7, B5TVM8, B5TVM9, E9Q9U5

Related

ENSMUSP00000107047.2, ENSMUST00000111416.7

Conserved Domains (2) summary

pfam05624
Location:201 → 227

LSR; Lipolysis stimulated receptor (LSR)

cl11960
Location:49 → 182

Ig; Immunoglobulin domain
NM_001357428.1 → NP_001344357.1 immunoglobulin-like domain-containing receptor 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC034122

Consensus CDS

CCDS87913.1

UniProtKB/TrEMBL

A0A0A6YXV2

Related

ENSMUSP00000142152.2, ENSMUST00000194964.6

Conserved Domains (1) summary

pfam05624
Location:201 → 227

LSR; Lipolysis stimulated receptor (LSR)
NM_001357429.1 → NP_001344358.1 immunoglobulin-like domain-containing receptor 2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC034122

Consensus CDS

CCDS87916.1

UniProtKB/TrEMBL

A0A0A6YWD2

Related

ENSMUSP00000141502.2, ENSMUST00000192732.6
NM_001357430.1 → NP_001344359.1 immunoglobulin-like domain-containing receptor 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC034122

Consensus CDS

CCDS87915.1

UniProtKB/TrEMBL

A0A0A6YY76

Related

ENSMUSP00000142311.2, ENSMUST00000192638.6

Conserved Domains (1) summary

pfam05624
Location:182 → 208

LSR; Lipolysis stimulated receptor (LSR)
NM_001357431.1 → NP_001344360.1 immunoglobulin-like domain-containing receptor 2 isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC034122

Consensus CDS

CCDS87914.1

UniProtKB/TrEMBL

A0A0A6YVY9

Related

ENSMUSP00000141323.2, ENSMUST00000193860.2

Conserved Domains (1) summary

cl11960
Location:132 → 181

Ig; Immunoglobulin domain
NM_001357432.1 → NP_001344361.1 immunoglobulin-like domain-containing receptor 2 isoform 6 precursor

Status: VALIDATED

Source sequence(s)

AC034122

Consensus CDS

CCDS87912.1

UniProtKB/TrEMBL

A0A0A6YY19

Related

ENSMUSP00000142240.2, ENSMUST00000195557.6

Conserved Domains (2) summary

pfam05624
Location:201 → 227

LSR; Lipolysis stimulated receptor (LSR)

cl11960
Location:49 → 182

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

166081630..166144405

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164352.1 → XP_036020245.1 immunoglobulin-like domain-containing receptor 2 isoform X2

Conserved Domains (1) summary

cl11960
Location:51 → 181

Ig; Immunoglobulin domain
XM_011238731.3 → XP_011237033.1 immunoglobulin-like domain-containing receptor 2 isoform X3

Conserved Domains (1) summary

cl11960
Location:132 → 181

Ig; Immunoglobulin domain
XM_006496594.5 → XP_006496657.1 immunoglobulin-like domain-containing receptor 2 isoform X1

Conserved Domains (2) summary

pfam05624
Location:170 → 196

LSR; Lipolysis stimulated receptor (LSR)

cl11960
Location:101 → 150

Ig; Immunoglobulin domain