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    A2ml1 alpha-2-macroglobulin like 1 [ Mus musculus (house mouse) ]

    Gene ID: 232400, updated on 23-Jun-2021

    Summary

    Official Symbol
    A2ml1provided by MGI
    Official Full Name
    alpha-2-macroglobulin like 1provided by MGI
    Primary source
    MGI:MGI:3039594
    See related
    Ensembl:ENSMUSG00000047228
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    O; Ovos; Ovos2
    Expression
    Biased expression in ovary adult (RPKM 19.2), liver E18 (RPKM 5.0) and 1 other tissue See more
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    Genomic context

    See A2ml1 in Genome Data Viewer
    Location:
    6; 6 F3
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128516785..128577014, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128539822..128581606, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (128489840..128531624, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene mitochondrial intermembrane space import and assembly protein 40 pseudogene Neighboring gene predicted pseudogene 8724 Neighboring gene killer cell lectin-like receptor subfamily B member 1A Neighboring gene predicted gene, 44478

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Homology

    Clone Names

    • MGC58520

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001179.3NP_001001179.2  ovostatin homolog precursor

      See identical proteins and their annotated locations for NP_001001179.2

      Status: VALIDATED

      Source sequence(s)
      AK138836, AK161068, AU044180
      Consensus CDS
      CCDS39651.1
      UniProtKB/Swiss-Prot
      Q3UU35
      UniProtKB/TrEMBL
      Q3TTY9
      Related
      ENSMUSP00000059426.8, ENSMUST00000060574.9
      Conserved Domains (6) summary
      cd02897
      Location:9561253
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:736826
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:121204
      A2M_N; MG2 domain
      pfam07677
      Location:13641447
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:10081253
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:450593
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      128516785..128577014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004942943.1 RNA Sequence

    2. XR_004942945.1 RNA Sequence

    3. XR_004942944.1 RNA Sequence

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