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    Metap2 methionine aminopeptidase 2 [ Mus musculus (house mouse) ]

    Gene ID: 56307, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Metap2provided by MGI
    Official Full Name
    methionine aminopeptidase 2provided by MGI
    Primary source
    MGI:MGI:1929701
    See related
    Ensembl:ENSMUSG00000036112 AllianceGenome:MGI:1929701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p67; Amp2; Mnpep; p67eIF2; 4930584B20Rik; A930035J23Rik
    Summary
    Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Predicted to be involved in N-terminal protein amino acid modification; peptidyl-methionine modification; and protein processing. Predicted to act upstream of or within proteolysis. Predicted to be located in cytosol and plasma membrane. Is expressed in brain and telencephalon. Orthologous to human METAP2 (methionyl aminopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 47.5), liver E14.5 (RPKM 37.1) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 C2; 10 48.69 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93694351..93732952, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93858489..93897090, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_27591 Neighboring gene STARR-positive B cell enhancer mm9_chr10:93281373-93281673 Neighboring gene STARR-seq mESC enhancer starr_27592 Neighboring gene predicted gene, 26239 Neighboring gene STARR-seq mESC enhancer starr_27593 Neighboring gene ubiquitin specific peptidase 44 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93352494-93352603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93401444-93401825 Neighboring gene STARR-seq mESC enhancer starr_27594 Neighboring gene microRNA 331 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene mitochondrial inner membrane protease subunit 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis. Esa R, et al. Int J Mol Sci, 2020 Jul 21. PMID 32708166, Free PMC Article
    2. 24-hour oscillation of mouse methionine aminopeptidase2, a regulator of tumor progression, is regulated by clock gene proteins. Nakagawa H, et al. Cancer Res, 2004 Nov 15. PMID 15548701
    3. Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition. Warder SE, et al. J Proteome Res, 2008 Nov. PMID 18828628
    4. Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation. Tucker LA, et al. Oncogene, 2008 Jun 26. PMID 18264137
    5. Cloning and characterization of complementary DNA encoding the eukaryotic initiation factor 2-associated 67-kDa protein (p67). Wu S, et al. J Biol Chem, 1993 May 25. PMID 8496145

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of p67(phox) in response to ischemia/reperfusion is cardioprotective by increasing ZIP2 expression via STAT3.
      Title: Upregulation of p67(phox) in response to ischemia/reperfusion is cardioprotective by increasing ZIP2 expression via STAT3.
    2. The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis.
      Title: The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis.
    3. MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity.
      Title: MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity.
    4. Discovery, identification, and characterization of candidate pharmacodynamic markers of Metap2 inhibition are reported.
      Title: Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition.
    5. MetAP2 plays an important role in tumor cell growth and may contribute to tumorigenesis
      Title: Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation.
    6. Data suggest that methionine aminopeptidase 2 plays a role in the proliferation of fibroblasts and myofibroblasts in fibrotic lung diseases and may serve as a novel pharmacologic target in idiopathic pulmonary fibrosis.
      Title: Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis.
    7. the functional role of S100A4 in regulating endothelial cell growth and tumor metastasis involves interaction with the N-terminal half of Methionine Aminopeptidase 2.
      Title: Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4.
    8. activity is regulated by the transcription of clock genes within the clock feedback loops
      Title: 24-hour oscillation of mouse methionine aminopeptidase2, a regulator of tumor progression, is regulated by clock gene proteins.
    9. The stability of p67 increases during myotube formation while inhibiting the phosphorylation of ERKs 1 and 2.
      Title: The stability of eukaryotic initiation factor 2-associated glycoprotein, p67, increases during skeletal muscle differentiation and that inhibits the phosphorylation of extracellular signal-regulated kinases 1 and 2.
    10. demonstrate an essential role for MetAP-2 in angiogenesis and indicate that MetAP-2 is responsible for the endothelial cell growth arrest induced by fumagillin and its derivatives
      Title: Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102452

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables initiator methionyl aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloexopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloexopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-methionine modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    methionine aminopeptidase 2
    Names
    MAP 2
    eIF-2-associated p67
    initiation factor 2-associated 67 kDa glycoprotein
    initiation factor 2-associated protein (p67)
    metAP 2
    peptidase M 2
    NP_062622.1
    XP_006513959.1
    XP_006513960.1
    XP_017169521.1
    XP_036011787.1
    XP_036011788.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019648.3 → NP_062622.1  methionine aminopeptidase 2

      See identical proteins and their annotated locations for NP_062622.1

      Status: VALIDATED

      Source sequence(s)
      AC124686, AF434712, AK165301
      Consensus CDS
      CCDS48673.1
      UniProtKB/Swiss-Prot
      O08663
      UniProtKB/TrEMBL
      Q3UI33, Q58E65
      Related
      ENSMUSP00000138006.2, ENSMUST00000180840.8
      Conserved Domains (1) summary
      PTZ00053
      Location:107 → 478
      PTZ00053; methionine aminopeptidase 2; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      93694351..93732952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513896.4 → XP_006513959.1  methionine aminopeptidase 2 isoform X1

      See identical proteins and their annotated locations for XP_006513959.1

      UniProtKB/Swiss-Prot
      O08663
      UniProtKB/TrEMBL
      Q3UI33, Q58E65
      Conserved Domains (1) summary
      PTZ00053
      Location:107 → 478
      PTZ00053; methionine aminopeptidase 2; Provisional

    2. XM_017314032.2 → XP_017169521.1  methionine aminopeptidase 2 isoform X2

      UniProtKB/TrEMBL
      Q3UI33
      Conserved Domains (1) summary
      PTZ00053
      Location:106 → 477
      PTZ00053; methionine aminopeptidase 2; Provisional

    3. XM_006513897.5 → XP_006513960.1  methionine aminopeptidase 2 isoform X1

      See identical proteins and their annotated locations for XP_006513960.1

      UniProtKB/Swiss-Prot
      O08663
      UniProtKB/TrEMBL
      Q3UI33, Q58E65
      Related
      ENSMUSP00000138083.2, ENSMUST00000181217.8
      Conserved Domains (1) summary
      PTZ00053
      Location:107 → 478
      PTZ00053; methionine aminopeptidase 2; Provisional

    4. XM_036155894.1 → XP_036011787.1  methionine aminopeptidase 2 isoform X1

      UniProtKB/Swiss-Prot
      O08663
      UniProtKB/TrEMBL
      Q3UI33, Q58E65
      Conserved Domains (1) summary
      PTZ00053
      Location:107 → 478
      PTZ00053; methionine aminopeptidase 2; Provisional

    5. XM_036155895.1 → XP_036011788.1  methionine aminopeptidase 2 isoform X2

      UniProtKB/TrEMBL
      Q3UI33
      Conserved Domains (1) summary
      PTZ00053
      Location:106 → 477
      PTZ00053; methionine aminopeptidase 2; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08663.1 GenPept UniProtKB/Swiss-Prot:O08663

    Gene LinkOut

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