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    Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 16490, updated on 5-Sep-2021

    Summary

    Official Symbol
    Kcna2provided by MGI
    Official Full Name
    potassium voltage-gated channel, shaker-related subfamily, member 2provided by MGI
    Primary source
    MGI:MGI:96659
    See related
    Ensembl:ENSMUSG00000040724
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Akr; Kv1.; Mk-2; Kca1-; Kv1.2; Akr6a4; Kca1-2; Gm10672
    Expression
    Biased expression in cerebellum adult (RPKM 17.1), cortex adult (RPKM 9.8) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kcna2 in Genome Data Viewer
    Location:
    3 F2.3; 3 46.61 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (106998203..107022321)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107090883..107115005)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (106904485..106909797)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AI504432 Neighboring gene predicted gene, 38712 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 3 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 10 Neighboring gene chymosin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables outward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within optic nerve structural organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of circadian sleep/wake cycle, non-REM sleep IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in juxtaparanode region of axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in juxtaparanode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily A member 2
    Names
    MK2
    voltage-gated potassium channel subunit Kv1.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008417.5NP_032443.3  potassium voltage-gated channel subfamily A member 2

      See identical proteins and their annotated locations for NP_032443.3

      Status: VALIDATED

      Source sequence(s)
      AC121825, AI607461, AK044342
      Consensus CDS
      CCDS17733.1
      UniProtKB/Swiss-Prot
      P63141
      Related
      ENSMUSP00000041702.2, ENSMUST00000038695.6
      Conserved Domains (2) summary
      cl38908
      Location:33159
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:162420
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      106998203..107022321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501055.5XP_006501118.1  potassium voltage-gated channel subfamily A member 2 isoform X1

      See identical proteins and their annotated locations for XP_006501118.1

      UniProtKB/Swiss-Prot
      P63141
      Conserved Domains (2) summary
      cl38908
      Location:33159
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:162420
      Ion_trans; Ion transport protein
    2. XM_036162906.1XP_036018799.1  potassium voltage-gated channel subfamily A member 2 isoform X1

      Conserved Domains (2) summary
      cl38908
      Location:33159
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:162420
      Ion_trans; Ion transport protein
    3. XM_006501049.5XP_006501112.1  potassium voltage-gated channel subfamily A member 2 isoform X1

      See identical proteins and their annotated locations for XP_006501112.1

      UniProtKB/Swiss-Prot
      P63141
      Related
      ENSMUSP00000143798.2, ENSMUST00000197470.5
      Conserved Domains (2) summary
      cl38908
      Location:33159
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:162420
      Ion_trans; Ion transport protein
    4. XM_006501052.5XP_006501115.1  potassium voltage-gated channel subfamily A member 2 isoform X1

      See identical proteins and their annotated locations for XP_006501115.1

      UniProtKB/Swiss-Prot
      P63141
      Conserved Domains (2) summary
      cl38908
      Location:33159
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:162420
      Ion_trans; Ion transport protein
    5. XM_006501051.5XP_006501114.1  potassium voltage-gated channel subfamily A member 2 isoform X1

      See identical proteins and their annotated locations for XP_006501114.1

      UniProtKB/Swiss-Prot
      P63141
      Conserved Domains (2) summary
      cl38908
      Location:33159
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:162420
      Ion_trans; Ion transport protein
    6. XM_006501053.5XP_006501116.1  potassium voltage-gated channel subfamily A member 2 isoform X1

      See identical proteins and their annotated locations for XP_006501116.1

      UniProtKB/Swiss-Prot
      P63141
      Conserved Domains (2) summary
      cl38908
      Location:33159
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:162420
      Ion_trans; Ion transport protein
    7. XM_006501050.4XP_006501113.1  potassium voltage-gated channel subfamily A member 2 isoform X1

      See identical proteins and their annotated locations for XP_006501113.1

      UniProtKB/Swiss-Prot
      P63141
      Related
      ENSMUSP00000142873.2, ENSMUST00000196403.2
      Conserved Domains (2) summary
      cl38908
      Location:33159
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:162420
      Ion_trans; Ion transport protein
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