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    Atad2 ATPase family, AAA domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 70472, updated on 23-Jun-2021

    Summary

    Official Symbol
    Atad2provided by MGI
    Official Full Name
    ATPase family, AAA domain containing 2provided by MGI
    Primary source
    MGI:MGI:1917722
    See related
    Ensembl:ENSMUSG00000022360
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610509G12Rik
    Expression
    Broad expression in liver E14 (RPKM 11.8), CNS E11.5 (RPKM 11.6) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Atad2 in Genome Data Viewer
    Location:
    15; 15 D1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (57957440..57998921, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58094044..58135525, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (57925602..57966637, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22299 Neighboring gene zinc fingers and homeoboxes 1 Neighboring gene small nuclear ribonucleoprotein Sm D2-like Neighboring gene WDYHV motif containing 1 Neighboring gene predicted gene, 23475 Neighboring gene predicted gene, 22488

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC38189

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of chromatin silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ATPase family AAA domain-containing protein 2
    NP_081711.2
    XP_036015476.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027435.2NP_081711.2  ATPase family AAA domain-containing protein 2

      See identical proteins and their annotated locations for NP_081711.2

      Status: VALIDATED

      Source sequence(s)
      AK029867, AK032877, BC071261
      Consensus CDS
      CCDS37079.1
      UniProtKB/Swiss-Prot
      Q8CDM1
      UniProtKB/TrEMBL
      G3X963, Q6IQY4
      Related
      ENSMUSP00000043691.4, ENSMUST00000038194.5
      Conserved Domains (3) summary
      cd05528
      Location:9601070
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      smart00382
      Location:438579
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:443577
      AAA; ATPase family associated with various cellular activities (AAA)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      57957440..57998921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159583.1XP_036015476.1  ATPase family AAA domain-containing protein 2 isoform X1

      Related
      ENSMUSP00000153936.2, ENSMUST00000228783.2
      Conserved Domains (4) summary
      cd05528
      Location:459569
      Bromo_AAA; Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this ...
      COG0464
      Location:3406
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      TIGR01243
      Location:3172
      CDC48; AAA family ATPase, CDC48 subfamily
      cl38936
      Location:174
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_384045.4 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153199.1: Suppressed sequence

      Description
      NM_153199.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center