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    Tbc1d31 TBC1 domain family, member 31 [ Mus musculus (house mouse) ]

    Gene ID: 210544, updated on 23-Jun-2021

    Summary

    Official Symbol
    Tbc1d31provided by MGI
    Official Full Name
    TBC1 domain family, member 31provided by MGI
    Primary source
    MGI:MGI:2684931
    See related
    Ensembl:ENSMUSG00000022364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4B3; Gm85; Wdr6; Wdr67; D330013L20Rik
    Expression
    Broad expression in testis adult (RPKM 7.4), CNS E11.5 (RPKM 4.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tbc1d31 in Genome Data Viewer
    Location:
    15; 15 D1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (57775081..57833464)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (57911685..57970068)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (57743754..57801623)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene zinc fingers and homeoboxes 2 Neighboring gene Der1-like domain family, member 1 Neighboring gene uncharacterized LOC115488500 Neighboring gene nuclear encoded tRNA methionine 16 (anticodon CAT) Neighboring gene family with sequence similarity 83, member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC76603

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TBC1 domain family member 31
    Names
    WD repeat domain 67
    WD repeat-containing protein 67
    protein 4-B-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081396.2NP_001074865.2  TBC1 domain family member 31 isoform 1

      See identical proteins and their annotated locations for NP_001074865.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      AC154874, BC050039, BC066830
      Consensus CDS
      CCDS37077.2
      UniProtKB/Swiss-Prot
      Q6NXY1
      Related
      ENSMUSP00000022992.7, ENSMUST00000022992.13
      Conserved Domains (6) summary
      COG2319
      Location:34346
      WD40; WD40 repeat [General function prediction only]
      pfam15346
      Location:766895
      ARGLU; Arginine and glutamate-rich 1
      sd00039
      Location:4381
      7WD40; WD40 repeat [structural motif]
      cl02495
      Location:461619
      RabGAP-TBC; Rab-GTPase-TBC domain
      cl02567
      Location:39334
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl23750
      Location:713834
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    2. NM_001167679.1NP_001161151.1  TBC1 domain family member 31 isoform 2

      See identical proteins and their annotated locations for NP_001161151.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154874
      UniProtKB/Swiss-Prot
      Q6NXY1
      Related
      ENSMUST00000110175.9
      Conserved Domains (5) summary
      COG2319
      Location:34346
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:4381
      7WD40; WD40 repeat [structural motif]
      cl02495
      Location:461619
      RabGAP-TBC; Rab-GTPase-TBC domain
      cl02567
      Location:39334
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl23750
      Location:713834
      vATP-synt_E; ATP synthase (E/31 kDa) subunit
    3. NM_001356310.1NP_001343239.1  TBC1 domain family member 31 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154874
      Conserved Domains (4) summary
      sd00039
      Location:4580
      7WD40; WD40 repeat [structural motif]
      cl02495
      Location:343520
      RabGAP-TBC; Rab-GTPase-TBC domain
      cl25539
      Location:30249
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl25545
      Location:599821
      V-ATPase_G_2; Vacuolar (H+)-ATPase G subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      57775081..57833464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520700.3XP_006520763.1  TBC1 domain family member 31 isoform X2

      See identical proteins and their annotated locations for XP_006520763.1

      Conserved Domains (4) summary
      sd00039
      Location:4580
      7WD40; WD40 repeat [structural motif]
      pfam17380
      Location:599921
      DUF5401; Family of unknown function (DUF5401)
      cl02495
      Location:343534
      RabGAP-TBC; Rab-GTPase-TBC domain
      cl29593
      Location:30249
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006520698.3XP_006520761.1  TBC1 domain family member 31 isoform X1

      Conserved Domains (4) summary
      sd00039
      Location:4381
      7WD40; WD40 repeat [structural motif]
      pfam17380
      Location:6841006
      DUF5401; Family of unknown function (DUF5401)
      cl02495
      Location:428619
      RabGAP-TBC; Rab-GTPase-TBC domain
      cl29593
      Location:39334
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_006520699.3XP_006520762.1  TBC1 domain family member 31 isoform X2

      See identical proteins and their annotated locations for XP_006520762.1

      Conserved Domains (4) summary
      sd00039
      Location:4580
      7WD40; WD40 repeat [structural motif]
      pfam17380
      Location:599921
      DUF5401; Family of unknown function (DUF5401)
      cl02495
      Location:343534
      RabGAP-TBC; Rab-GTPase-TBC domain
      cl29593
      Location:30249
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_030248441.1XP_030104301.1  TBC1 domain family member 31 isoform X3

      Conserved Domains (4) summary
      sd00039
      Location:944
      7WD40; WD40 repeat [structural motif]
      pfam17380
      Location:563874
      DUF5401; Family of unknown function (DUF5401)
      cl02495
      Location:307498
      RabGAP-TBC; Rab-GTPase-TBC domain
      cl29593
      Location:1213
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_036159297.1XP_036015190.1  TBC1 domain family member 31 isoform X4

      Conserved Domains (4) summary
      sd00039
      Location:944
      7WD40; WD40 repeat [structural motif]
      pfam17380
      Location:563820
      DUF5401; Family of unknown function (DUF5401)
      cl02495
      Location:307498
      RabGAP-TBC; Rab-GTPase-TBC domain
      cl29593
      Location:1213
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    6. XM_006520702.3XP_006520765.1  TBC1 domain family member 31 isoform X3

      See identical proteins and their annotated locations for XP_006520765.1

      Conserved Domains (4) summary
      sd00039
      Location:944
      7WD40; WD40 repeat [structural motif]
      pfam17380
      Location:563874
      DUF5401; Family of unknown function (DUF5401)
      cl02495
      Location:307498
      RabGAP-TBC; Rab-GTPase-TBC domain
      cl29593
      Location:1213
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    7. XM_006520703.3XP_006520766.1  TBC1 domain family member 31 isoform X3

      See identical proteins and their annotated locations for XP_006520766.1

      Conserved Domains (4) summary
      sd00039
      Location:944
      7WD40; WD40 repeat [structural motif]
      pfam17380
      Location:563874
      DUF5401; Family of unknown function (DUF5401)
      cl02495
      Location:307498
      RabGAP-TBC; Rab-GTPase-TBC domain
      cl29593
      Location:1213
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199300.1: Suppressed sequence

      Description
      NM_199300.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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