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    Zhx1 zinc fingers and homeoboxes 1 [ Mus musculus (house mouse) ]

    Gene ID: 22770, updated on 23-Jun-2021

    Summary

    Official Symbol
    Zhx1provided by MGI
    Official Full Name
    zinc fingers and homeoboxes 1provided by MGI
    Primary source
    MGI:MGI:109271
    See related
    Ensembl:ENSMUSG00000022361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in bladder adult (RPKM 9.2), CNS E18 (RPKM 8.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Zhx1 in Genome Data Viewer
    Location:
    15; 15 D1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (57910399..57939904, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58047003..58076508, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (57878558..57908044, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118568198 Neighboring gene predicted gene, 22299 Neighboring gene ATPase family, AAA domain containing 2 Neighboring gene small nuclear ribonucleoprotein Sm D2-like Neighboring gene WDYHV motif containing 1 Neighboring gene predicted gene, 23475

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4149, mKIAA4149, 3110006I21Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc fingers and homeoboxes protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042438.2NP_001035903.1  zinc fingers and homeoboxes protein 1

      See identical proteins and their annotated locations for NP_001035903.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC113292, AK220508, BC054543, CJ093421, CN533009
      Consensus CDS
      CCDS27488.1
      UniProtKB/Swiss-Prot
      P70121
      UniProtKB/TrEMBL
      Q5DTL2
      Related
      ENSMUSP00000105797.2, ENSMUST00000110168.8
      Conserved Domains (3) summary
      smart00389
      Location:665716
      HOX; Homeodomain
      cd00086
      Location:468523
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:785821
      Homez; Homeodomain leucine-zipper encoding, Homez
    2. NM_009572.4NP_033598.2  zinc fingers and homeoboxes protein 1

      See identical proteins and their annotated locations for NP_033598.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC113292, AK220508, BC054543, CJ093421
      Consensus CDS
      CCDS27488.1
      UniProtKB/Swiss-Prot
      P70121
      UniProtKB/TrEMBL
      Q5DTL2
      Related
      ENSMUSP00000066201.7, ENSMUST00000070143.13
      Conserved Domains (3) summary
      smart00389
      Location:665716
      HOX; Homeodomain
      cd00086
      Location:468523
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:785821
      Homez; Homeodomain leucine-zipper encoding, Homez

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      57910399..57939904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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