Hdac11 histone deacetylase 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hdac11provided by MGI
Official Full Name: histone deacetylase 11provided by MGI
Primary source: MGI:MGI:2385252
See related: Ensembl:ENSMUSG00000034245 AllianceGenome:MGI:2385252
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable histone deacetylase activity. Predicted to be involved in histone deacetylation and oligodendrocyte development. Predicted to be located in nucleus and plasma membrane. Predicted to be part of histone deacetylase complex. Orthologous to human HDAC11 (histone deacetylase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 59.4), cerebellum adult (RPKM 42.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 40.38 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (91133652..91151674)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (91156670..91174692)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Development of a novel histone deacetylase inhibitor unveils the role of HDAC11 in alleviating depression by inhibition of microglial activation.
Title: Development of a novel histone deacetylase inhibitor unveils the role of HDAC11 in alleviating depression by inhibition of microglial activation.
HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3.
Title: HDAC11 negatively regulates antifungal immunity by inhibiting Nos2 expression via binding with transcriptional repressor STAT3.
Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model.
Title: Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model.
Loss of HDAC11 accelerates skeletal muscle regeneration in mice.
Title: Loss of HDAC11 accelerates skeletal muscle regeneration in mice.
HDAC11 is a novel regulator of fatty acid oxidative metabolism in skeletal muscle.
Title: HDAC11 is a novel regulator of fatty acid oxidative metabolism in skeletal muscle.
HDAC11 regulates expression of C/EBPbeta and immunosuppressive molecules in myeloid-derived suppressor cells.
Title: HDAC11 regulates expression of C/EBPβ and immunosuppressive molecules in myeloid-derived suppressor cells.
HDAC11 promotes meiotic apparatus assembly during mouse oocyte maturation via decreasing H4K16 and alpha-tubulin acetylation.
Title: HDAC11 promotes meiotic apparatus assembly during mouse oocyte maturation via decreasing H4K16 and α-tubulin acetylation.
study establishes HDAC11 as a unique type of target molecule that has therapeutic potential in myeloproliferative neoplasms
Title: HDAC11 deficiency disrupts oncogene-induced hematopoiesis in myeloproliferative neoplasms.
Ex vivo and cell-based assays revealed that Hdac11 catalytic activity suppresses the BAT transcriptional program, in both the basal state and in response to beta-adrenergic receptor signaling, through a mechanism that is dependent on physical association with Brd2. These findings define an epigenetic pathway for the regulation of energy homeostasis.
Title: HDAC11 suppresses the thermogenic program of adipose tissue via BRD2.
Loss of HDAC11 had no obvious impact on brain morphology and neural stem/precursor cells isolated from Hdac11 (KO/KO) mice had comparable proliferation and differentiation characteristics. However, in differentiating neural cells this study observed decreased expression of schizophrenia-associated gene Fez1.
Title: Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	TAS Traceable Author Statement more info	PubMed
enables histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity	ISO Inferred from Sequence Orthology more info
enables histone deacetylase activity	TAS Traceable Author Statement more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	TAS Traceable Author Statement more info	PubMed
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligodendrocyte development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
part_of histone deacetylase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	TAS Traceable Author Statement more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone deacetylase 11

Names: HD11

NP_659168.1

EC 3.5.1.98

XP_036021947.1

EC 3.5.1.98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144919.2 → NP_659168.1 histone deacetylase 11

See identical proteins and their annotated locations for NP_659168.1

Status: PROVISIONAL

Source sequence(s)

AC110256, AC131764

Consensus CDS

CCDS20366.1

UniProtKB/Swiss-Prot

Q91WA3

UniProtKB/TrEMBL

Q543U1

Related

ENSMUSP00000043828.5, ENSMUST00000041736.11

Conserved Domains (1) summary

cd09993
Location:35 → 319

HDAC_classIV; Histone deacetylase class IV also known as histone deacetylase 11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

91133652..91151674

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036166054.1 → XP_036021947.1 histone deacetylase 11 isoform X1

Conserved Domains (1) summary

cd09993
Location:16 → 197

HDAC_classIV; Histone deacetylase class IV also known as histone deacetylase 11