Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Bmf BCL2 modifying factor [ Mus musculus (house mouse) ]

    Gene ID: 171543, updated on 5-Jul-2021

    Summary

    Official Symbol
    Bmfprovided by MGI
    Official Full Name
    BCL2 modifying factorprovided by MGI
    Primary source
    MGI:MGI:2176433
    See related
    Ensembl:ENSMUSG00000040093
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW260063; AW411872
    Expression
    Ubiquitous expression in lung adult (RPKM 8.9), thymus adult (RPKM 8.8) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Bmf in Genome Data Viewer
    Location:
    2; 2 E5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118359238..118385280, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118528757..118549686, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (118354493..118375414, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member B3 pseudogene Neighboring gene predicted gene, 32684 Neighboring gene eukaryotic translation initiation factor 5A pseudogene Neighboring gene BUB1B, mitotic checkpoint serine/threonine kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anoikis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of autophagic cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of release of cytochrome c from mitochondria IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of myosin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of myosin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of myosin complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311140.2NP_001298069.1  bcl-2-modifying factor isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compard to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL929381
      Consensus CDS
      CCDS79835.1
      UniProtKB/TrEMBL
      A2AV74
      Related
      ENSMUSP00000106483.3, ENSMUST00000110859.3
      Conserved Domains (1) summary
      pfam15185
      Location:9188
      BMF; Bcl-2-modifying factor, apoptosis
    2. NM_001331221.1NP_001318150.1  bcl-2-modifying factor isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AL929381
      Consensus CDS
      CCDS89538.1
      UniProtKB/Swiss-Prot
      Q91ZE9
      Related
      ENSMUSP00000159051.2, ENSMUST00000125860.3
      Conserved Domains (1) summary
      pfam15185
      Location:4183
      BMF; Bcl-2-modifying factor, apoptosis
    3. NM_138313.4NP_612186.2  bcl-2-modifying factor isoform 1

      See identical proteins and their annotated locations for NP_612186.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK040622, AK084658, AL929381
      Consensus CDS
      CCDS16578.1
      UniProtKB/Swiss-Prot
      Q91ZE9
      UniProtKB/TrEMBL
      A2AV75
      Related
      ENSMUSP00000087686.7, ENSMUST00000090219.13
      Conserved Domains (1) summary
      pfam15185
      Location:90269
      BMF; Bcl-2-modifying factor, apoptosis

    RNA

    1. NR_138603.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter and differs at the 5' end compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the open reading frame found in variant 1.
      Source sequence(s)
      AL929381

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      118359238..118385280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158999.1XP_036014892.1  bcl-2-modifying factor isoform X1

      Conserved Domains (1) summary
      pfam15185
      Location:81260
      BMF; Bcl-2-modifying factor, apoptosis
    2. XM_006498855.2XP_006498918.1  bcl-2-modifying factor isoform X2

      See identical proteins and their annotated locations for XP_006498918.1

      UniProtKB/Swiss-Prot
      Q91ZE9
      Conserved Domains (1) summary
      pfam15185
      Location:4183
      BMF; Bcl-2-modifying factor, apoptosis
    3. XM_036159004.1XP_036014897.1  bcl-2-modifying factor isoform X2

      Conserved Domains (1) summary
      pfam15185
      Location:4183
      BMF; Bcl-2-modifying factor, apoptosis
    Support Center