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    Apoa2 apolipoprotein A-II [ Mus musculus (house mouse) ]

    Gene ID: 11807, updated on 23-Jun-2021

    Summary

    Official Symbol
    Apoa2provided by MGI
    Official Full Name
    apolipoprotein A-IIprovided by MGI
    Primary source
    MGI:MGI:88050
    See related
    Ensembl:ENSMUSG00000005681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; Al; Ap; Hdl-; Alp-2; Hdl-1; ApoAII; Apoa-2; Apo-AII; ApoA-II
    Summary
    This gene encodes a component of high density lipoproteins (HDL). Mice lacking the encoded protein have low HDL-cholesterol levels, smaller HDL particles, increased clearance of triglyceride-rich lipoproteins and insulin hypersensitivity. Transgenic mice overexpressing the encoded protein have elevated levels of HDL-cholesterol and show increased susceptibility to atherosclerosis. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]
    Expression
    Biased expression in liver adult (RPKM 4143.8), liver E18 (RPKM 1768.2) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Apoa2 in Genome Data Viewer
    Location:
    1 H3; 1 79.22 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171049133..171053948)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171221564..171226379)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (173155185..173156510)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Purkinje cell protein 4-like 1 Neighboring gene nuclear receptor subfamily 1, group I, member 3 Neighboring gene translocase of outer mitochondrial membrane 40-like Neighboring gene Fc receptor, IgE, high affinity I, gamma polypeptide Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables apolipoprotein receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables apolipoprotein receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to cholesterol transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cholesterol transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables high-density lipoprotein particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables high-density lipoprotein particle binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables high-density lipoprotein particle receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables high-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lipase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine-sterol O-acyltransferase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in animal organ regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in diacylglycerol catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in high-density lipoprotein particle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in high-density lipoprotein particle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in high-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in high-density lipoprotein particle remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in high-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipoprotein metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within lipoprotein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in low-density lipoprotein particle remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in low-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cholesterol import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cholesterol transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of very-low-density lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-methionine modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid efflux ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol esterification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of intestinal cholesterol absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reverse cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride-rich lipoprotein particle remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in triglyceride-rich lipoprotein particle remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of chylomicron IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of chylomicron ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spherical high-density lipoprotein particle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of spherical high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of very-low-density lipoprotein particle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of very-low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    apolipoprotein A-II
    Names
    apolipoprotein A2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305549.1NP_001292478.1  apolipoprotein A-II preproprotein

      See identical proteins and their annotated locations for NP_001292478.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC084821, BY780589, X62772
      Consensus CDS
      CCDS35773.1
      UniProtKB/Swiss-Prot
      P09813
      Related
      ENSMUSP00000106953.2, ENSMUST00000111321.8
      Conserved Domains (1) summary
      pfam04711
      Location:2498
      ApoA-II; Apolipoprotein A-II (ApoA-II)
    2. NM_001305550.1NP_001292479.1  apolipoprotein A-II preproprotein

      See identical proteins and their annotated locations for NP_001292479.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC084821, BY780589, X62772
      Consensus CDS
      CCDS35773.1
      UniProtKB/Swiss-Prot
      P09813
      Related
      ENSMUSP00000106952.2, ENSMUST00000111320.8
      Conserved Domains (1) summary
      pfam04711
      Location:2498
      ApoA-II; Apolipoprotein A-II (ApoA-II)
    3. NM_001305585.1NP_001292514.1  apolipoprotein A-II preproprotein

      See identical proteins and their annotated locations for NP_001292514.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC084821, BU609941
      Consensus CDS
      CCDS35773.1
      UniProtKB/Swiss-Prot
      P09813
      Conserved Domains (1) summary
      pfam04711
      Location:2498
      ApoA-II; Apolipoprotein A-II (ApoA-II)
    4. NM_013474.2NP_038502.2  apolipoprotein A-II preproprotein

      See identical proteins and their annotated locations for NP_038502.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AK145823, BY780589, CB947382
      Consensus CDS
      CCDS35773.1
      UniProtKB/Swiss-Prot
      P09813
      Related
      ENSMUSP00000005824.6, ENSMUST00000005824.12
      Conserved Domains (1) summary
      pfam04711
      Location:2498
      ApoA-II; Apolipoprotein A-II (ApoA-II)

    RNA

    1. NR_131173.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' region and lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AA060885, AC084821, BY780589

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171049133..171053948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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