Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pcnt pericentrin (kendrin) [ Mus musculus (house mouse) ]

    Gene ID: 18541, updated on 7-Sep-2021

    Summary

    Official Symbol
    Pcntprovided by MGI
    Official Full Name
    pericentrin (kendrin)provided by MGI
    Primary source
    MGI:MGI:102722
    See related
    Ensembl:ENSMUSG00000001151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KEN; Pcn; m239; m275; Pcnt2; C86676; kendrin; m239Asp; m275Asp; AW476095
    Expression
    Ubiquitous expression in testis adult (RPKM 7.7), lung adult (RPKM 6.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pcnt in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (76187088..76279988, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (76351254..76442912, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (75813999..75905657, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene S100 protein, beta polypeptide, neural Neighboring gene disco interacting protein 2 homolog A Neighboring gene predicted gene, 40699 Neighboring gene RIKEN cDNA 1700094J05 gene Neighboring gene RIKEN cDNA 2610028H24 gene Neighboring gene ybeY metallopeptidase Neighboring gene minichromosome maintenance complex component 3 associated protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Chemically induced (ENU) (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebellar cortex morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within head development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within olfactory bulb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spindle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium TAS
    Traceable Author Statement
    more info
     
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in pericentriolar material IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    pericentrin
    Names
    pericentrin 2
    pericentrin-250
    pericentrin-360

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282992.1NP_001269921.1  pericentrin isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AB207233, AC158618, AK122275, BM219062
      Consensus CDS
      CCDS88027.1
      UniProtKB/Swiss-Prot
      P48725
      UniProtKB/TrEMBL
      A0A1W2P737, Q80U10
      Related
      ENSMUSP00000151534.2, ENSMUST00000217838.2
      Conserved Domains (6) summary
      COG1196
      Location:4751375
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5281
      Location:305577
      COG5281; Phage-related minor tail protein [Mobilome: prophages, transposons]
      pfam09455
      Location:10501214
      Cas_DxTHG; CRISPR-associated (Cas) DxTHG family
      pfam10495
      Location:27012779
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
      pfam12474
      Location:154308
      PKK; Polo kinase kinase
      pfam15290
      Location:14131479
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp
    2. NM_008787.3NP_032813.3  pericentrin isoform a

      See identical proteins and their annotated locations for NP_032813.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC158618, AK029906, AK163352, BC085244, BM219062, U05823
      Consensus CDS
      CCDS23944.1
      UniProtKB/Swiss-Prot
      P48725
      UniProtKB/TrEMBL
      F8VPV0, Q3TQR8, Q8CDL2
      Related
      ENSMUSP00000001179.6, ENSMUST00000001179.7
      Conserved Domains (6) summary
      COG1196
      Location:4751375
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5281
      Location:305577
      COG5281; Phage-related minor tail protein [Mobilome: prophages, transposons]
      pfam09455
      Location:10501214
      Cas_DxTHG; CRISPR-associated (Cas) DxTHG family
      pfam10495
      Location:27192797
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
      pfam12474
      Location:154308
      PKK; Polo kinase kinase
      pfam15290
      Location:14131479
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      76187088..76279988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244950.2XP_030100810.1  pericentrin isoform X8

      Conserved Domains (4) summary
      PTZ00121
      Location:133647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:4751368
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:12181551
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:27892867
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    2. XM_011243383.4XP_011241685.1  pericentrin isoform X5

      Conserved Domains (4) summary
      PTZ00121
      Location:133647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:4751375
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:12181558
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:27962874
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    3. XM_036155685.1XP_036011578.1  pericentrin isoform X13

      Conserved Domains (3) summary
      PTZ00121
      Location:133647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:4751386
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10495
      Location:27122790
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    4. XM_017313839.3XP_017169328.1  pericentrin isoform X2

      Conserved Domains (4) summary
      PTZ00121
      Location:133647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:4751386
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:12291564
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:28072885
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    5. XM_011243384.4XP_011241686.1  pericentrin isoform X7

      Conserved Domains (4) summary
      PTZ00121
      Location:133647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:4751369
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:12191552
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:27902868
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    6. XM_006513353.5XP_006513416.1  pericentrin isoform X15

      Conserved Domains (4) summary
      PTZ00121
      Location:133647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:4751376
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:12191559
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:27022780
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    7. XM_006513348.5XP_006513411.1  pericentrin isoform X10

      Conserved Domains (4) summary
      PTZ00121
      Location:133647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:4751376
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:12191559
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:27792857
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    8. XM_011243382.4XP_011241684.1  pericentrin isoform X4

      Conserved Domains (4) summary
      PTZ00121
      Location:133647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:4751376
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:12191559
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:27972875
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    9. XM_036155686.1XP_036011579.1  pericentrin isoform X14

      Conserved Domains (3) summary
      PTZ00121
      Location:133647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:4751380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10495
      Location:27062784
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    10. XM_036155684.1XP_036011577.1  pericentrin isoform X9

      Conserved Domains (3) summary
      PTZ00121
      Location:133647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:4751380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10495
      Location:27832861
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    11. XM_017313840.3XP_017169329.1  pericentrin isoform X3

      Conserved Domains (4) summary
      PTZ00121
      Location:133647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:4751380
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:12301558
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:28012879
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    12. XM_017313843.3XP_017169332.1  pericentrin isoform X12

      Conserved Domains (4) summary
      PTZ00121
      Location:133647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:4751387
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:12301565
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:27132791
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    13. XM_017313841.3XP_017169330.1  pericentrin isoform X6

      Conserved Domains (4) summary
      PTZ00121
      Location:133647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:4751387
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:12301565
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:27902868
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    14. XM_017313842.3XP_017169331.1  pericentrin isoform X11

      Conserved Domains (4) summary
      PTZ00121
      Location:133647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:4751387
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:12301565
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:27312809
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    15. XM_017313838.3XP_017169327.1  pericentrin isoform X1

      Conserved Domains (4) summary
      PTZ00121
      Location:133647
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:4751387
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:12301565
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:28082886
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    16. XM_036155687.1XP_036011580.1  pericentrin isoform X16

      Conserved Domains (3) summary
      COG1196
      Location:545897
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:4896
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:23182396
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    17. XM_017313845.3XP_017169334.1  pericentrin isoform X17

      Conserved Domains (3) summary
      COG1196
      Location:138470
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:313648
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:18911969
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    18. XM_006513356.3XP_006513419.1  pericentrin isoform X19

      Related
      ENSMUST00000220395.2
      Conserved Domains (3) summary
      COG1196
      Location:138459
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:302642
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:17851863
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    19. XM_036155688.1XP_036011581.1  pericentrin isoform X18

      Conserved Domains (3) summary
      COG1196
      Location:138470
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:11141392
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam10495
      Location:17961874
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    Support Center