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    Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 74147, updated on 11-Jul-2021

    Summary

    Official Symbol
    Ehhadhprovided by MGI
    Official Full Name
    enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:1277964
    See related
    Ensembl:ENSMUSG00000022853
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HD; MF; L-P; LBP; MFP; LBFP; MFE1; MFP1; PBFE; L-PBE; MFP-1; 1300002P22Rik
    Expression
    Biased expression in liver E18 (RPKM 121.5), kidney adult (RPKM 92.4) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ehhadh in Genome Data Viewer
    Location:
    16; 16 B1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (21580035..21606589, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (21761285..21787834, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (21761358..21787907, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene VPS8 CORVET complex subunit Neighboring gene predicted gene, 50612 Neighboring gene RIKEN cDNA 2510009E07 gene Neighboring gene RIKEN cDNA 1300002E11 gene Neighboring gene mitogen-activated protein kinase kinase kinase 13 Neighboring gene 60S ribosomal protein L12 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 3-hydroxyacyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3-hydroxyacyl-CoA dehydrogenase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dodecenoyl-CoA delta-isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enoyl-CoA hydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables intramolecular oxidoreductase activity, transposing C=C bonds ISO
    Inferred from Sequence Orthology
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisome TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    peroxisomal bifunctional enzyme
    Names
    L-bifunctional enzyme
    L-peroxisomal bifunctional enzyme
    L-specific multifunctional beta-oxdiation protein
    PBE
    multifunctional enzyme 1
    multifunctional protein 1
    NP_076226.2
    XP_006522721.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023737.3NP_076226.2  peroxisomal bifunctional enzyme

      See identical proteins and their annotated locations for NP_076226.2

      Status: VALIDATED

      Source sequence(s)
      AC130214, AK004867, BB841865
      Consensus CDS
      CCDS28063.1
      UniProtKB/Swiss-Prot
      Q9DBM2
      Related
      ENSMUSP00000023559.6, ENSMUST00000023559.7
      Conserved Domains (4) summary
      cd06558
      Location:12186
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
      PRK11154
      Location:20702
      fadJ; multifunctional fatty acid oxidation complex subunit alpha; Reviewed
      pfam00725
      Location:473577
      3HCDH; 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
      pfam02737
      Location:297471
      3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      21580035..21606589 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522658.5XP_006522721.1  peroxisomal bifunctional enzyme isoform X1

      Conserved Domains (1) summary
      PRK11154
      Location:21646
      fadJ; fatty acid oxidation complex subunit alpha FadJ
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