Slc51b solute carrier family 51, beta subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc51bprovided by MGI
Official Full Name: solute carrier family 51, beta subunitprovided by MGI
Primary source: MGI:MGI:3582052
See related: Ensembl:ENSMUSG00000053862 AllianceGenome:MGI:3582052
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ostb
Summary: Enables bile acid transmembrane transporter activity and protein heterodimerization activity. Involved in several processes, including bile acid and bile salt transport; positive regulation of intracellular protein transport; and positive regulation of protein glycosylation. Acts upstream of or within organic substance transport. Located in basolateral plasma membrane. Is integral component of membrane. Part of protein-containing complex. Is expressed in small intestine. Orthologous to human SLC51B (solute carrier family 51 subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 36.0), testis adult (RPKM 7.5) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 C; 9 35.29 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (65320035..65330055, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (65412753..65422773, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that transport of bile acid taurocholate is retained when OstB is truncated to contain only the transmembrane domain with 15 additional residues on each side and co-expressed with intact OstA (organic solute transporter alpha subunit); shorter fragments of OstB are inactive.
Title: Global functions of extracellular, transmembrane and cytoplasmic domains of organic solute transporter β-subunit.
These findings provide direct support for the hypothesis that Ostalpha-Ostbeta is a major basolateral transporter of bile acids and conjugated steroids in the intestine, kidney, and liver.
Title: Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver.
These data indicate that Ostalpha-Ostbeta is essential for intestinal bile acid transport in mice.
Title: The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis.
Present as heterodimers (with Ost alpha) and/or heteromultimers; the interaction between Ostalpha and Ostbeta increases the stability of the proteins and is required for delivery of the heteromeric complex to the plasma membrane.
Title: Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter.
These results indicate that expression of Ostalpha and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor.
Title: Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents.
The mouse Ostalpha and Ostbeta promoters are unusual in that they contain functional FXR and LRH elements, which mediate, respectively, positive and negative feedback regulation by bile acids.
Title: Regulation of the mouse organic solute transporter alpha-beta, Ostalpha-Ostbeta, by bile acids.
the selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.
Title: OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia.
In conclusion, we identified Ost-alpha/Ost-beta as a novel FXR target. Absent Ost-alpha/Ost-beta induction in CA-fed FXR(-/-) animals may contribute to increased liver injury in these animals.
Title: Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids.
Co-expression of mouse Ostalpha-Ostbeta, but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate
Title: The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter.
OSTalpha and OSTbeta mRNA levels were induced in the adrenals and kidneys of wild-type, but not FXR-/-, mice
Title: FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

BQ196694 (e-PCR)
- UniSTS:260662

D9Mit360 (e-PCR), detects polymorphism
- UniSTS:142809

NoName (e-PCR)
- UniSTS:493020

RH137558 (e-PCR)
- UniSTS:219645

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter activity	IPI Inferred from Physical Interaction more info	PubMed
enables transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid and bile salt transport	IDA Inferred from Direct Assay more info	PubMed
involved_in bile acid and bile salt transport	IPI Inferred from Physical Interaction more info	PubMed
involved_in bile acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within organic substance transport	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of protein exit from endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein glycosylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein targeting to membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein stability	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: organic solute transporter subunit beta

Names: OST-beta; Ost beta; organic solute transporter beta; solute carrier family 51 subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.